CA2351735C - Engineered cytotoxic ribonuclease - Google Patents
Engineered cytotoxic ribonuclease Download PDFInfo
- Publication number
- CA2351735C CA2351735C CA2351735A CA2351735A CA2351735C CA 2351735 C CA2351735 C CA 2351735C CA 2351735 A CA2351735 A CA 2351735A CA 2351735 A CA2351735 A CA 2351735A CA 2351735 C CA2351735 C CA 2351735C
- Authority
- CA
- Canada
- Prior art keywords
- ribonuclease
- modified
- steric hindrance
- rnase
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 108010083644 Ribonucleases Proteins 0.000 title claims abstract description 122
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- 108020002230 Pancreatic Ribonuclease Proteins 0.000 claims abstract description 58
- 102000005891 Pancreatic ribonuclease Human genes 0.000 claims abstract description 58
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/199,242 | 1998-11-24 | ||
| US09/199,242 US6280991B1 (en) | 1997-10-15 | 1998-11-24 | Engineered cytotoxic ribonclease |
| PCT/US1999/027670 WO2000031242A2 (en) | 1998-11-24 | 1999-11-22 | Engineered cytotoxic ribonuclease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2351735A1 CA2351735A1 (en) | 2000-06-02 |
| CA2351735C true CA2351735C (en) | 2011-09-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2351735A Expired - Fee Related CA2351735C (en) | 1998-11-24 | 1999-11-22 | Engineered cytotoxic ribonuclease |
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| Country | Link |
|---|---|
| US (1) | US6280991B1 (https=) |
| EP (1) | EP1131417A2 (https=) |
| JP (2) | JP4731015B2 (https=) |
| AU (1) | AU778024B2 (https=) |
| CA (1) | CA2351735C (https=) |
| IL (2) | IL143036A0 (https=) |
| WO (1) | WO2000031242A2 (https=) |
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| CA2489446A1 (en) * | 2002-06-14 | 2003-12-24 | Wisconsin Alumni Research Foundation | Ribonuclease zymogen design |
| WO2004085611A2 (en) * | 2003-03-21 | 2004-10-07 | The Research Foundation Of State University Of New York | Model for mutually exclusive domain folding molecular switch |
| WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
| CA2604243C (en) | 2004-04-14 | 2015-11-24 | Avirid, Inc. | Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases |
| US7655757B2 (en) * | 2005-06-16 | 2010-02-02 | Wisconsin Alumni Research Foundation | Cytotoxic ribonuclease variants |
| WO2006138458A1 (en) * | 2005-06-16 | 2006-12-28 | Wisconsin Alumni Research Foundation | Cytotoxic ribonuclease variants |
| WO2007041361A1 (en) * | 2005-09-30 | 2007-04-12 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer | Modified recombinant anti-tumor rnase |
| EP2044097A4 (en) * | 2006-06-23 | 2010-10-06 | Quintessence Biosciences Inc | Modified ribonucleases |
| US8298801B2 (en) | 2006-07-17 | 2012-10-30 | Quintessence Biosciences, Inc. | Methods and compositions for the treatment of cancer |
| US8069251B2 (en) * | 2007-06-01 | 2011-11-29 | Adobe Systems Incorporated | System and/or method for client-driven server load distribution |
| EP2205271B1 (en) * | 2007-10-08 | 2014-05-21 | Quintessence Biosciences, Inc. | Compositions and methods for ribonuclease-based therapies |
| WO2009088992A2 (en) * | 2008-01-07 | 2009-07-16 | University Of Vermont And State Agricultural College | Ribonuclease and thiazolidinedione compounds and their use in methods to treat cancer |
| US8029782B2 (en) | 2008-10-01 | 2011-10-04 | Quintessence Biosciences, Inc. | Therapeutic ribonucleases |
| KR101934923B1 (ko) | 2009-11-02 | 2019-04-10 | 유니버시티 오브 워싱톤 스루 이츠 센터 포 커머셜리제이션 | 치료학적 뉴클레아제 조성물 및 방법 |
| PH12013502441B1 (en) | 2011-04-29 | 2019-02-08 | Univ Washington | Therapeutic nuclease compositions and methods |
| PL3063275T3 (pl) | 2013-10-31 | 2020-03-31 | Resolve Therapeutics, Llc | Terapeutyczne fuzje nukleaza-albumina i sposoby |
| ES2971441T3 (es) * | 2016-05-06 | 2024-06-05 | Biodynamic Res Foundation | Composición farmacéutica que contiene un fármaco macromolecular |
| JP7308034B2 (ja) | 2016-07-01 | 2023-07-13 | リゾルブ セラピューティクス， エルエルシー | 最適化二重ヌクレアーゼ融合物および方法 |
| BR112020003670A2 (pt) | 2017-08-22 | 2020-09-01 | Sanabio, Llc | receptores de interferon solúveis e usos dos mesmos |
| US11286469B2 (en) | 2017-11-09 | 2022-03-29 | Wisconsin Alumni Research Foundation | Combination chemotherapy for the treatment of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840840A (en) | 1990-04-17 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Selective RNase cytotoxic reagents |
| US5389537A (en) | 1994-01-21 | 1995-02-14 | Wisconsin Alumni Research Foundation | Nuclease having altered specificity |
| US5840296A (en) * | 1997-10-15 | 1998-11-24 | Raines; Ronald T. | Engineered cytotoxic ribonuclease A |
-
1998
- 1998-11-24 US US09/199,242 patent/US6280991B1/en not_active Expired - Lifetime
-
1999
- 1999-11-22 AU AU19184/00A patent/AU778024B2/en not_active Ceased
- 1999-11-22 EP EP99962821A patent/EP1131417A2/en not_active Withdrawn
- 1999-11-22 JP JP2000584053A patent/JP4731015B2/ja not_active Expired - Fee Related
- 1999-11-22 CA CA2351735A patent/CA2351735C/en not_active Expired - Fee Related
- 1999-11-22 IL IL14303699A patent/IL143036A0/xx unknown
- 1999-11-22 WO PCT/US1999/027670 patent/WO2000031242A2/en not_active Ceased
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2001
- 2001-05-08 IL IL143036A patent/IL143036A/en not_active IP Right Cessation
-
2010
- 2010-12-06 JP JP2010271615A patent/JP2011078428A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002532067A (ja) | 2002-10-02 |
| JP2011078428A (ja) | 2011-04-21 |
| WO2000031242A2 (en) | 2000-06-02 |
| AU778024B2 (en) | 2004-11-11 |
| JP4731015B2 (ja) | 2011-07-20 |
| US6280991B1 (en) | 2001-08-28 |
| IL143036A0 (en) | 2002-04-21 |
| CA2351735A1 (en) | 2000-06-02 |
| AU1918400A (en) | 2000-06-13 |
| IL143036A (en) | 2009-06-15 |
| WO2000031242A3 (en) | 2000-11-23 |
| EP1131417A2 (en) | 2001-09-12 |
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