CA2350758A1 - Benzylglycosylamides utilises comme inhibiteurs de proliferation des cellules du muscle lisse - Google Patents

Benzylglycosylamides utilises comme inhibiteurs de proliferation des cellules du muscle lisse Download PDF

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Publication number
CA2350758A1
CA2350758A1 CA002350758A CA2350758A CA2350758A1 CA 2350758 A1 CA2350758 A1 CA 2350758A1 CA 002350758 A CA002350758 A CA 002350758A CA 2350758 A CA2350758 A CA 2350758A CA 2350758 A1 CA2350758 A1 CA 2350758A1
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Canada
Prior art keywords
carbon atoms
substituted
hydrogen
independently
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002350758A
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English (en)
Inventor
Folake Oluwemimo Adebayo
Robert Emmett Mcdevitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
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Individual
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Publication of CA2350758A1 publication Critical patent/CA2350758A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Cette invention concerne des inhibiteurs de prolifération des cellules du muscle lisse, ou un sel pharmaceutiquement acceptable desdits inhibiteurs, qui présentent une structure de la formule (I) dans laquelle Y est C ou N; n est compris entre 0 et 3; X est représenté par la formule (A); R?1¿ et R?2¿ sont chacun, indépendamment de l'autre, hydrogène, un alkyle comprenant 1 à 6 atomes de carbone, halo, acétyle, phényle, CF¿3?, CN, OH, NO¿2?, NH¿2?, un alcoxy comprenant 1 à 6 atomes de carbone, ou un alcoxynitrile comprenant 1 à 6 atomes de carbone; R?3¿ est hydrogène, un acylamide comprenant 2 à 6 atomes de carbone ou un alcoxy comprenant 1 à 6 atomes de carbone; R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ sont chacun, indépendamment des autres, hydrogène, un acyle comprenant 1 à 6 atomes de carbone, benzyle substitué par R?1¿ et R?2¿, ou benzoyle substitué par R?1¿ et R?2¿; R?9¿ et R?10¿ sont chacun, indépendamment de l'autre, un acyle comprenant 1 à 6 atomes de carbone, ou les groupes R?9¿ et R?10¿ aux positions 4' et 6' du maltose peuvent être pris ensemble pour former un acétal cyclique pouvant être substitué par un alkyle comprenant 1 à 6 atomes de carbone, deux groupes alkyle ayant chacun entre 1 et 6 atomes de carbone, pyridine substitué par R?1¿, phényle substitué par R?1¿, benzyle substitué par R?1¿, 2-phényléthyle substitué par R?1¿, ou 3-phénylpropyle substitué par R?1¿.
CA002350758A 1998-11-24 1999-11-23 Benzylglycosylamides utilises comme inhibiteurs de proliferation des cellules du muscle lisse Abandoned CA2350758A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19843298A 1998-11-24 1998-11-24
US09/198,432 1998-11-24
PCT/US1999/027780 WO2000031093A2 (fr) 1998-11-24 1999-11-23 Benzylglycosylamides utilises comme inhibiteurs de proliferation des cellules du muscle lisse

Publications (1)

Publication Number Publication Date
CA2350758A1 true CA2350758A1 (fr) 2000-06-02

Family

ID=22733358

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002350758A Abandoned CA2350758A1 (fr) 1998-11-24 1999-11-23 Benzylglycosylamides utilises comme inhibiteurs de proliferation des cellules du muscle lisse

Country Status (7)

Country Link
EP (1) EP1133508A2 (fr)
JP (1) JP2002530418A (fr)
CN (1) CN1333781A (fr)
AU (1) AU1743700A (fr)
BR (1) BR9915612A (fr)
CA (1) CA2350758A1 (fr)
WO (1) WO2000031093A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350755A1 (fr) * 1998-11-24 2000-06-02 Robert Emmett Mcdevitt Benzylglycosylamides utilises comme inhibiteurs de la proliferation cellulaire des muscles lisses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3655327B2 (ja) * 1994-05-09 2005-06-02 三井化学株式会社 オリゴ糖鎖を有するスチレン誘導体およびその製造方法
DE4436164A1 (de) * 1994-10-10 1996-04-11 Hoechst Ag Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion
CA2350755A1 (fr) * 1998-11-24 2000-06-02 Robert Emmett Mcdevitt Benzylglycosylamides utilises comme inhibiteurs de la proliferation cellulaire des muscles lisses

Also Published As

Publication number Publication date
WO2000031093A2 (fr) 2000-06-02
WO2000031093A3 (fr) 2000-12-28
BR9915612A (pt) 2001-08-14
EP1133508A2 (fr) 2001-09-19
CN1333781A (zh) 2002-01-30
JP2002530418A (ja) 2002-09-17
AU1743700A (en) 2000-06-13

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