CA2343354A1 - Inhibiteur du brn-3b et son utilisation dans le traitement contre le cancer du sein et le cancer des ovaires - Google Patents

Inhibiteur du brn-3b et son utilisation dans le traitement contre le cancer du sein et le cancer des ovaires Download PDF

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Publication number
CA2343354A1
CA2343354A1 CA002343354A CA2343354A CA2343354A1 CA 2343354 A1 CA2343354 A1 CA 2343354A1 CA 002343354 A CA002343354 A CA 002343354A CA 2343354 A CA2343354 A CA 2343354A CA 2343354 A1 CA2343354 A1 CA 2343354A1
Authority
CA
Canada
Prior art keywords
brn
inhibitor
expression
substance
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002343354A
Other languages
English (en)
Inventor
David Seymour Latchman
Vishwanie Budhram-Mahadeo
Daniel Ndisang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2343354A1 publication Critical patent/CA2343354A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La présente invention concerne un inhibiteur de l'expression et/ou de l'activité du Brn-3b, lequel inhibiteur convient particulièrement au traitement du cancer de sein ou du cancer des ovaires. L'invention concerne également un procédé aboutissant à l'identification d'un inhibiteur du Brn-3b. Ce procédé consiste (a) à prendre une construction test comprenant un promoteur du Brn-3b fonctionnellement lié à une séquence codante. Le procédé consiste ensuite (b) à mettre en contact avec la construction test une substance à tester dans les conditions qui permettraient au polypeptide codé par la séquence codante considérée de s'exprimer en l'absence de la substance considérée. Le procédé consiste enfin (c) à déterminer si la substance considérée inhibe l'expression du Brn-3b.
CA002343354A 1998-09-14 1999-09-14 Inhibiteur du brn-3b et son utilisation dans le traitement contre le cancer du sein et le cancer des ovaires Abandoned CA2343354A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9819999.5 1998-09-14
GBGB9819999.5A GB9819999D0 (en) 1998-09-14 1998-09-14 Treatment of cancer
PCT/GB1999/003047 WO2000015780A1 (fr) 1998-09-14 1999-09-14 Inhibiteur du brn-3b et son utilisation dans le traitement contre le cancer du sein et le cancer des ovaires

Publications (1)

Publication Number Publication Date
CA2343354A1 true CA2343354A1 (fr) 2000-03-23

Family

ID=10838839

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343354A Abandoned CA2343354A1 (fr) 1998-09-14 1999-09-14 Inhibiteur du brn-3b et son utilisation dans le traitement contre le cancer du sein et le cancer des ovaires

Country Status (6)

Country Link
EP (1) EP1112356A1 (fr)
JP (1) JP2002525269A (fr)
AU (1) AU5874899A (fr)
CA (1) CA2343354A1 (fr)
GB (1) GB9819999D0 (fr)
WO (1) WO2000015780A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4272748A3 (fr) 2004-06-28 2024-03-27 The University Of Western Australia Oligonucléotides antisens pour induire l'omission de l'exon et leurs procédés d'utilisation
JP5864257B2 (ja) 2008-10-24 2016-02-17 サレプタ セラピューティクス， インコーポレイテッド Ｄｍｄのための複数のエキソンスキッピング組成物
CN105838714B (zh) 2009-11-12 2020-07-17 西澳大利亚大学 反义分子和治疗疾病的方法
EA035882B1 (ru) 2013-03-14 2020-08-27 Сарепта Терапьютикс, Инк. Антисмысловые олигонуклеотиды, обеспечивающие пропуск экзонов, для лечения мышечной дистрофии
BR112015022998A2 (pt) 2013-03-15 2017-11-14 Sarepta Therapeutics Inc composições melhoradas para o tratamento de distrofia muscular

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001511344A (ja) * 1997-07-25 2001-08-14 ニューロヴェックス リミテッド 転写因子Ｂｒｎ−３ａの使用

Also Published As

Publication number Publication date
EP1112356A1 (fr) 2001-07-04
GB9819999D0 (en) 1998-11-04
WO2000015780A1 (fr) 2000-03-23
JP2002525269A (ja) 2002-08-13
AU5874899A (en) 2000-04-03

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