CA2343100A1 - Procede de fabrication de timbres matriciels autocollants contenant des sels hydrophiles de medicaments - Google Patents

Procede de fabrication de timbres matriciels autocollants contenant des sels hydrophiles de medicaments Download PDF

Info

Publication number
CA2343100A1
CA2343100A1 CA002343100A CA2343100A CA2343100A1 CA 2343100 A1 CA2343100 A1 CA 2343100A1 CA 002343100 A CA002343100 A CA 002343100A CA 2343100 A CA2343100 A CA 2343100A CA 2343100 A1 CA2343100 A1 CA 2343100A1
Authority
CA
Canada
Prior art keywords
drug
hci
adhesive
pressure sensitive
sensitive adhesive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002343100A
Other languages
English (en)
Inventor
Srinivasan Venkateshwaran
Charles D. Ebert
David Fikstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Finance LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2343100A1 publication Critical patent/CA2343100A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un procédé de fabrication de timbre matriciel autocollant permettant d'administrer un médicament par voie transdermique est présentée. La méthode consiste à dissoudre le médicament sous forme de sel hydrophile dans la phase aqueuse d'une dispersion d'un autocollant hydrophobe, à couler le mélange qui en résulte en un film fin,et à faire évaporer l'eau. La stabilité physique du médicament dans le film est excellente et on évite toute crystallisation du médicament. Une méthode permettant d'augmenter le flux transdermique d'un médicament acide est également présentée.
CA002343100A 1998-09-08 1999-09-08 Procede de fabrication de timbres matriciels autocollants contenant des sels hydrophiles de medicaments Abandoned CA2343100A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14952398A 1998-09-08 1998-09-08
US09/149,523 1998-09-08
PCT/US1999/020814 WO2000024386A1 (fr) 1998-09-08 1999-09-08 Procede de fabrication de timbres matriciels autocollants contenant des sels hydrophiles de medicaments

Publications (1)

Publication Number Publication Date
CA2343100A1 true CA2343100A1 (fr) 2000-05-04

Family

ID=22530677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002343100A Abandoned CA2343100A1 (fr) 1998-09-08 1999-09-08 Procede de fabrication de timbres matriciels autocollants contenant des sels hydrophiles de medicaments

Country Status (5)

Country Link
EP (1) EP1117389A1 (fr)
JP (1) JP2003520191A (fr)
AU (1) AU5820699A (fr)
CA (1) CA2343100A1 (fr)
WO (1) WO2000024386A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20221397U1 (de) * 2001-03-16 2005-10-20 Alza Corp., Mountain View Transdermal-Pflaster zum Verabreichen von Fentanyl
US7797375B2 (en) 2001-05-07 2010-09-14 International Business Machines Corporat System and method for responding to resource requests in distributed computer networks
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20110086086A1 (en) * 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
WO2007035939A2 (fr) 2005-09-23 2007-03-29 Alza Corporation Formulation de polyacrylate superieur avec chargement d'activateur destinee a des applications transdermiques
US20070098772A1 (en) 2005-09-23 2007-05-03 Westcott Tyler D Transdermal norelgestromin delivery system
CA3138128C (fr) * 2008-03-31 2024-02-13 Passport Technologies, Inc. Systeme d'administration de permeant et procedes d'utilisation de celui-ci
CA2739380C (fr) * 2008-10-06 2014-12-09 Mylan Technologies, Inc. Systeme transdermique de rotigotine amorphe
FR2963889B1 (fr) 2010-08-20 2013-04-12 Debregeas Et Associes Pharma Formulations a base de nalbuphine et leurs utilisations
EP2809307B1 (fr) * 2012-01-31 2017-12-20 Grünenthal GmbH Timbre pharmaceutique pour l'administration transdermique de (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine
WO2014144109A1 (fr) * 2013-03-15 2014-09-18 Naimco, Inc. Timbre transdermique ayant un adhésif non-soluble dans l'eau et un anesthésique
WO2023048192A1 (fr) * 2021-09-27 2023-03-30 久光製薬株式会社 Procédé d'inhibition de production d'indolinones de diclofénac
KR20240005127A (ko) * 2021-09-27 2024-01-11 히사미쓰 세이야꾸 가부시키가이샤 디클로페낙인돌리논체의 생성을 억제하는 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310559A (en) * 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US5633009A (en) * 1990-11-28 1997-05-27 Sano Corporation Transdermal administration of azapirones
JP2849950B2 (ja) * 1990-11-30 1999-01-27 日東電工株式会社 経皮吸収製剤
US5883115A (en) * 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
US5985317A (en) * 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
ES2237104T3 (es) * 1998-04-29 2005-07-16 Virotex Corporation Dispositivo portador de productos farmaceuticos adecuado para el aporte de compuestos farmaceuticos a superficies mucosas.

Also Published As

Publication number Publication date
WO2000024386A1 (fr) 2000-05-04
JP2003520191A (ja) 2003-07-02
EP1117389A1 (fr) 2001-07-25
AU5820699A (en) 2000-05-15

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EEER Examination request
FZDE Dead