CA2342625A1 - Lipstatin derivative-soluble fiber tablets - Google Patents
Lipstatin derivative-soluble fiber tablets Download PDFInfo
- Publication number
- CA2342625A1 CA2342625A1 CA002342625A CA2342625A CA2342625A1 CA 2342625 A1 CA2342625 A1 CA 2342625A1 CA 002342625 A CA002342625 A CA 002342625A CA 2342625 A CA2342625 A CA 2342625A CA 2342625 A1 CA2342625 A1 CA 2342625A1
- Authority
- CA
- Canada
- Prior art keywords
- methylcellulose
- composition according
- mixture
- tablet
- lipase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- OQMAKWGYQLJJIA-CUOOPAIESA-N lipstatin Chemical class CCCCCC[C@H]1[C@H](C[C@H](C\C=C/C\C=C/CCCCC)OC(=O)[C@H](CC(C)C)NC=O)OC1=O OQMAKWGYQLJJIA-CUOOPAIESA-N 0.000 title abstract description 19
- 239000000835 fiber Substances 0.000 title description 10
- SIKWOTFNWURSAY-UHFFFAOYSA-N Lipstatin Natural products CCCCCCC1C(CC(CC=CCC=CCCCCC)C(=O)OC(CC(C)C)NC=O)OC1=O SIKWOTFNWURSAY-UHFFFAOYSA-N 0.000 title description 8
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 63
- 239000001923 methylcellulose Substances 0.000 claims abstract description 63
- 239000003085 diluting agent Substances 0.000 claims abstract description 36
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 97
- 239000003826 tablet Substances 0.000 claims description 73
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 47
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 47
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 47
- 229940086609 Lipase inhibitor Drugs 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 29
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical group CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims description 28
- 229960001243 orlistat Drugs 0.000 claims description 27
- 229920002261 Corn starch Polymers 0.000 claims description 25
- 239000008120 corn starch Substances 0.000 claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims description 24
- 239000008187 granular material Substances 0.000 claims description 23
- 229940099112 cornstarch Drugs 0.000 claims description 20
- 229940032147 starch Drugs 0.000 claims description 20
- 235000019698 starch Nutrition 0.000 claims description 20
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 18
- 159000000007 calcium salts Chemical class 0.000 claims description 18
- 235000010980 cellulose Nutrition 0.000 claims description 18
- 229920002678 cellulose Polymers 0.000 claims description 18
- 239000001913 cellulose Substances 0.000 claims description 18
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 18
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 18
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 18
- 230000008569 process Effects 0.000 claims description 18
- 239000000080 wetting agent Substances 0.000 claims description 18
- 239000000314 lubricant Substances 0.000 claims description 16
- 229920002472 Starch Polymers 0.000 claims description 15
- 238000004040 coloring Methods 0.000 claims description 15
- 239000008107 starch Substances 0.000 claims description 15
- 239000007884 disintegrant Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 14
- 239000008109 sodium starch glycolate Substances 0.000 claims description 11
- 229920003109 sodium starch glycolate Polymers 0.000 claims description 11
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 11
- 239000011230 binding agent Substances 0.000 claims description 10
- 208000034347 Faecal incontinence Diseases 0.000 claims description 8
- 206010041969 Steatorrhoea Diseases 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical group [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 8
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims description 8
- 208000001162 steatorrhea Diseases 0.000 claims description 8
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 7
- 239000007891 compressed tablet Substances 0.000 claims description 6
- -1 veegum Polymers 0.000 claims description 6
- 239000007916 tablet composition Substances 0.000 claims description 5
- 241000124008 Mammalia Species 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 230000009977 dual effect Effects 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
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- 229920001615 Tragacanth Polymers 0.000 claims 2
- 238000011260 co-administration Methods 0.000 claims 2
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- 229920001817 Agar Polymers 0.000 claims 1
- 235000013912 Ceratonia siliqua Nutrition 0.000 claims 1
- 240000008886 Ceratonia siliqua Species 0.000 claims 1
- 244000303965 Cyamopsis psoralioides Species 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 240000007472 Leucaena leucocephala Species 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 235000015125 Sterculia urens Nutrition 0.000 claims 1
- 240000001058 Sterculia urens Species 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
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- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 56
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 46
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 45
- 238000009472 formulation Methods 0.000 description 31
- 235000019359 magnesium stearate Nutrition 0.000 description 28
- 229940069328 povidone Drugs 0.000 description 28
- 239000004615 ingredient Substances 0.000 description 22
- 229920003084 Avicel® PH-102 Polymers 0.000 description 20
- 229920003108 Methocel™ A4M Polymers 0.000 description 20
- 239000003925 fat Substances 0.000 description 17
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- 229940127470 Lipase Inhibitors Drugs 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
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- 239000000243 solution Substances 0.000 description 4
- 239000002028 Biomass Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- AHLBNYSZXLDEJQ-UHFFFAOYSA-N N-formyl-L-leucylester Natural products CCCCCCCCCCCC(OC(=O)C(CC(C)C)NC=O)CC1OC(=O)C1CCCCCC AHLBNYSZXLDEJQ-UHFFFAOYSA-N 0.000 description 3
- 229960005069 calcium Drugs 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
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- 229940079593 drug Drugs 0.000 description 3
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- 239000012530 fluid Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 239000004150 EU approved colour Substances 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- JKNGELGDDBUFHG-UHFFFAOYSA-N Esterastin Natural products CCCCCCC1C(CC(CC=CCC=CCCCCC)OC(=O)C(CC(N)=O)NC(C)=O)OC1=O JKNGELGDDBUFHG-UHFFFAOYSA-N 0.000 description 2
- 206010021639 Incontinence Diseases 0.000 description 2
- 108050006759 Pancreatic lipases Proteins 0.000 description 2
- 102000019280 Pancreatic lipases Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- JKNGELGDDBUFHG-JJPNXARGSA-N [(2S,4Z,7Z)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl] (2S)-2-acetamido-4-amino-4-oxobutanoate Chemical compound CCCCCC[C@H]1[C@H](C[C@H](C\C=C/C\C=C/CCCCC)OC(=O)[C@H](CC(N)=O)NC(C)=O)OC1=O JKNGELGDDBUFHG-JJPNXARGSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
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- 235000014113 dietary fatty acids Nutrition 0.000 description 2
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- 229940088598 enzyme Drugs 0.000 description 2
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- 229930195729 fatty acid Natural products 0.000 description 2
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- 150000002632 lipids Chemical class 0.000 description 2
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- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical compound CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 241001550224 Apha Species 0.000 description 1
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- LJMJTWHHROBQOE-DZUOILHNSA-N [(2s)-1-[(2s,3s)-3-ethyl-4-oxooxetan-2-yl]nonadecan-2-yl] (2s)-2-formamido-4-methylpentanoate Chemical compound CCCCCCCCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CC LJMJTWHHROBQOE-DZUOILHNSA-N 0.000 description 1
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9939998P | 1998-09-08 | 1998-09-08 | |
| US60/099,399 | 1998-09-08 | ||
| PCT/US1999/020744 WO2000013667A1 (en) | 1998-09-08 | 1999-09-08 | Lipstatin derivative-soluble fiber tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2342625A1 true CA2342625A1 (en) | 2000-03-16 |
Family
ID=22274826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002342625A Abandoned CA2342625A1 (en) | 1998-09-08 | 1999-09-08 | Lipstatin derivative-soluble fiber tablets |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6607749B1 (enExample) |
| EP (1) | EP1112063A4 (enExample) |
| JP (1) | JP2002524410A (enExample) |
| AU (1) | AU745697B2 (enExample) |
| CA (1) | CA2342625A1 (enExample) |
| NZ (1) | NZ510311A (enExample) |
| WO (1) | WO2000013667A1 (enExample) |
| ZA (1) | ZA200101904B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6607749B1 (en) * | 1998-09-08 | 2003-08-19 | Smithkline Beecham Corporation | Lipstatin derivative-soluble fiber tablets |
| RU2241462C2 (ru) | 2000-07-28 | 2004-12-10 | Ф. Хоффманн-Ля Рош Аг | Новая фармацевтическая композиция |
| DE10160409A1 (de) * | 2001-12-10 | 2003-06-18 | Guenther Beisel | Verwendung von ionischen und nichtionischen Celluloseethern zur Herstellung eines gelartigen Mittels zur Verhinderung der Resorption von Fetten aus dem Magen-Darm-Trakt |
| US20040091450A1 (en) * | 2002-02-26 | 2004-05-13 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
| US20080075688A1 (en) * | 2003-10-31 | 2008-03-27 | The Procter & Gamble Company | Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body |
| EP1681050A1 (en) * | 2005-01-13 | 2006-07-19 | Strides Arcolab Limited | Dispersible sustained release pharmaceutical compositions |
| WO2006085497A1 (ja) * | 2005-02-09 | 2006-08-17 | Kissei Pharmaceutical Co., Ltd. | 口腔内崩壊錠 |
| US20070123490A1 (en) * | 2005-11-30 | 2007-05-31 | Yokoyama Wallace H | Preventing or reducing oxidative stress or oxidative cell injury |
| US20080119540A1 (en) * | 2006-11-21 | 2008-05-22 | D.N. Halgren | Method of using oral lipase inhibitors to reduce plasma ghrelin and to prevent weight regain |
| GB0618725D0 (en) * | 2006-09-23 | 2006-11-01 | Jagotec Ag | Composition containing inhibitors of gastro-intestinal lipase |
| NZ580891A (en) * | 2007-05-16 | 2012-06-29 | Buckman Labor Inc | Methods to control organic contaminants in fibers in paper making systems |
| EP2002825B1 (en) * | 2007-06-14 | 2013-05-22 | Krka | Pharmaceutical compositions comprising orlistat |
| US20100112122A1 (en) * | 2008-04-30 | 2010-05-06 | Yun-Jeong Hong | Method of preferentially reducing absorbability of saturated fatty acids |
| KR20100075260A (ko) * | 2008-12-24 | 2010-07-02 | 주식회사종근당 | 리파아제 저해제의 부작용 개선을 위한 신규한 약제학적 조성물 |
| CN102362863B (zh) * | 2011-11-21 | 2013-06-12 | 山东新时代药业有限公司 | 一种含奥利司他的制剂及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5438167B2 (enExample) * | 1974-04-27 | 1979-11-19 | ||
| JPS608117B2 (ja) | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | 新生理活性物質エステラスチンおよびその製造法 |
| GB2023604B (en) | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
| US5374430A (en) * | 1986-09-18 | 1994-12-20 | London School Of Pharmacy | Pharmaceutical formulation |
| US5576306A (en) * | 1991-03-01 | 1996-11-19 | Dow Chemical Company | Pharmaceutical compositions and uses of water-soluble, high-viscosity grade cellulose ethers |
| HUT70029A (en) * | 1991-08-14 | 1995-09-28 | Procter & Gamble Pharma | Novel cyclic urea derivatives and antiarrhythmic and antifibrillatory compositions containing them |
| US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| CA2098167C (en) * | 1992-06-24 | 2006-12-19 | Dorothea Isler | Foodstuffs and feedstuffs containing a lipase inhibitor |
| TW381025B (en) | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| US5451409A (en) * | 1993-11-22 | 1995-09-19 | Rencher; William F. | Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends |
| US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| AU8699298A (en) * | 1997-08-11 | 1999-03-01 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
| AR017512A1 (es) * | 1997-08-22 | 2001-09-12 | Smithkline Beecham Corp | Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas |
| AR016827A1 (es) | 1997-08-22 | 2001-08-01 | Smithkline Beecham Corp | PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA |
| AU759388B2 (en) | 1998-08-14 | 2003-04-10 | Cheplapharm Arzneimittel Gmbh | Pharmaceutical compositions containing lipase inhibitors and chitosan |
| TR200100471T2 (tr) | 1998-08-14 | 2001-07-23 | F.Hoffmann-La Roche Ag | Lipaz inhibitörleri içeren farmasötik bileşimler |
| US6607749B1 (en) * | 1998-09-08 | 2003-08-19 | Smithkline Beecham Corporation | Lipstatin derivative-soluble fiber tablets |
| FR2795326B1 (fr) * | 1999-06-28 | 2001-08-31 | Adir | Composition pharmaceutique solide thermoformable a liberation controlee |
-
1999
- 1999-09-08 US US09/786,518 patent/US6607749B1/en not_active Expired - Fee Related
- 1999-09-08 CA CA002342625A patent/CA2342625A1/en not_active Abandoned
- 1999-09-08 NZ NZ510311A patent/NZ510311A/en not_active IP Right Cessation
- 1999-09-08 WO PCT/US1999/020744 patent/WO2000013667A1/en not_active Ceased
- 1999-09-08 JP JP2000568476A patent/JP2002524410A/ja active Pending
- 1999-09-08 AU AU58198/99A patent/AU745697B2/en not_active Ceased
- 1999-09-08 EP EP99945631A patent/EP1112063A4/en not_active Ceased
-
2001
- 2001-03-07 ZA ZA2001/01904A patent/ZA200101904B/en unknown
-
2003
- 2003-06-24 US US10/602,955 patent/US7393545B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ510311A (en) | 2003-08-29 |
| EP1112063A1 (en) | 2001-07-04 |
| AU745697B2 (en) | 2002-03-28 |
| US6607749B1 (en) | 2003-08-19 |
| US20030232077A1 (en) | 2003-12-18 |
| WO2000013667A1 (en) | 2000-03-16 |
| JP2002524410A (ja) | 2002-08-06 |
| AU5819899A (en) | 2000-03-27 |
| US7393545B2 (en) | 2008-07-01 |
| ZA200101904B (en) | 2002-06-26 |
| EP1112063A4 (en) | 2009-05-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |