CA2342278A1 - Inhibition de transcription d'oncogenes par des polyamides synthetiques - Google Patents

Inhibition de transcription d'oncogenes par des polyamides synthetiques Download PDF

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Publication number
CA2342278A1
CA2342278A1 CA002342278A CA2342278A CA2342278A1 CA 2342278 A1 CA2342278 A1 CA 2342278A1 CA 002342278 A CA002342278 A CA 002342278A CA 2342278 A CA2342278 A CA 2342278A CA 2342278 A1 CA2342278 A1 CA 2342278A1
Authority
CA
Canada
Prior art keywords
polyamide
correspond
dsdna
nucleotide
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002342278A
Other languages
English (en)
Inventor
Peter B. Dervan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2342278A1 publication Critical patent/CA2342278A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polyamides (AREA)

Abstract

L'invention concerne des polyamides capables d'inhiber la transcription d'oncogènes. De préférence, les polyamides comprennent au moins trois paires complémentaires de résidus de carboxamides aromatiques se liant au sillon mineur d'un ADN à double brin. En ce qui concerne chaque polyamide, l'appariement complémentaire de quelques-uns ou de la totalité des résidus de carboxamides aromatiques du polyamide détermine la séquence nucléotidique cible d'une cible d'ADN à double brin identifiée dans la région d'activation d'un oncogène.
CA002342278A 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques Abandoned CA2342278A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9985498P 1998-09-11 1998-09-11
US60/099,854 1998-09-11
PCT/US1999/020489 WO2000015773A2 (fr) 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques

Publications (1)

Publication Number Publication Date
CA2342278A1 true CA2342278A1 (fr) 2000-03-23

Family

ID=22276927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002342278A Abandoned CA2342278A1 (fr) 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques

Country Status (5)

Country Link
EP (1) EP1112267A2 (fr)
JP (1) JP2003505521A (fr)
AU (1) AU5910899A (fr)
CA (1) CA2342278A1 (fr)
WO (1) WO2000015773A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122626B2 (en) 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
EP1470119A4 (fr) 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc Composes benzothiophene presentant une activite anti-infectieuse
US6777425B2 (en) 2001-06-13 2004-08-17 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
US6716866B2 (en) 2001-06-13 2004-04-06 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
US20030236198A1 (en) 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
WO2004012736A1 (fr) 2002-08-02 2004-02-12 Genesoft Pharmaceuticals, Inc. Composes biaryle a action anti-infectieuse
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
WO2004052304A2 (fr) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Composes antibacteriens possedant un motif (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide)
JPWO2007034784A1 (ja) * 2005-09-20 2009-03-26 学校法人日本大学 Ｃｔｇｆ遺伝子発現抑制剤
WO2007103584A2 (fr) * 2006-03-09 2007-09-13 Nanovir, Llc Polyamides pour le traitement du virus du papillome humain
US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection
US7589171B2 (en) 2006-05-04 2009-09-15 Nanovir, Llc Polyamides for treating human papilloma virus
US9133228B2 (en) 2011-10-10 2015-09-15 Nanovir Llc Guanidinyl-substituted polyamides useful for treating human papilloma virus
US9982020B2 (en) 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
US10723716B2 (en) 2016-12-21 2020-07-28 New York University Alpha-helix mimetics as modulators of Abeta self-assembly

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0973740A1 (fr) * 1996-02-26 2000-01-26 California Institute Of Technology Conception, synthese et utilisation de ligands a base de polyamides specifiques pour liaison a l'adn
AU734715B2 (en) * 1996-02-26 2001-06-21 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded DNA
US6660255B1 (en) * 1996-08-01 2003-12-09 California Institute Of Technology Inhibition of gene transcription by polyamide DNA-binding ligands
CA2286232A1 (fr) * 1997-04-06 1998-11-05 California Institute Of Technology Derives de polyamides pyrrole-imidazole liant l'adn

Also Published As

Publication number Publication date
JP2003505521A (ja) 2003-02-12
EP1112267A2 (fr) 2001-07-04
WO2000015773A3 (fr) 2000-08-17
AU5910899A (en) 2000-04-03
WO2000015773A2 (fr) 2000-03-23

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