WO2000015773A3 - Inhibition de transcription d'oncogenes par des polyamides synthetiques - Google Patents

Inhibition de transcription d'oncogenes par des polyamides synthetiques Download PDF

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Publication number
WO2000015773A3
WO2000015773A3 PCT/US1999/020489 US9920489W WO0015773A3 WO 2000015773 A3 WO2000015773 A3 WO 2000015773A3 US 9920489 W US9920489 W US 9920489W WO 0015773 A3 WO0015773 A3 WO 0015773A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibition
synthetic polyamides
polyamide
polyamides
oncogene
Prior art date
Application number
PCT/US1999/020489
Other languages
English (en)
Other versions
WO2000015773A2 (fr
WO2000015773A9 (fr
Inventor
Peter B Dervan
Original Assignee
California Inst Of Techn
Peter B Dervan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Peter B Dervan filed Critical California Inst Of Techn
Priority to EP99946779A priority Critical patent/EP1112267A2/fr
Priority to CA002342278A priority patent/CA2342278A1/fr
Priority to AU59108/99A priority patent/AU5910899A/en
Priority to JP2000570300A priority patent/JP2003505521A/ja
Publication of WO2000015773A2 publication Critical patent/WO2000015773A2/fr
Publication of WO2000015773A3 publication Critical patent/WO2000015773A3/fr
Publication of WO2000015773A9 publication Critical patent/WO2000015773A9/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des polyamides capables d'inhiber la transcription d'oncogènes. De préférence, les polyamides comprennent au moins trois paires complémentaires de résidus de carboxamides aromatiques se liant au sillon mineur d'un ADN à double brin. En ce qui concerne chaque polyamide, l'appariement complémentaire de quelques-uns ou de la totalité des résidus de carboxamides aromatiques du polyamide détermine la séquence nucléotidique cible d'une cible d'ADN à double brin identifiée dans la région d'activation d'un oncogène.
PCT/US1999/020489 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques WO2000015773A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99946779A EP1112267A2 (fr) 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques
CA002342278A CA2342278A1 (fr) 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques
AU59108/99A AU5910899A (en) 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides
JP2000570300A JP2003505521A (ja) 1998-09-11 1999-09-10 合成ポリアミドによる癌遺伝子転写の阻害

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9985498P 1998-09-11 1998-09-11
US60/099,854 1998-09-11

Publications (3)

Publication Number Publication Date
WO2000015773A2 WO2000015773A2 (fr) 2000-03-23
WO2000015773A3 true WO2000015773A3 (fr) 2000-08-17
WO2000015773A9 WO2000015773A9 (fr) 2002-04-25

Family

ID=22276927

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020489 WO2000015773A2 (fr) 1998-09-11 1999-09-10 Inhibition de transcription d'oncogenes par des polyamides synthetiques

Country Status (5)

Country Link
EP (1) EP1112267A2 (fr)
JP (1) JP2003505521A (fr)
AU (1) AU5910899A (fr)
CA (1) CA2342278A1 (fr)
WO (1) WO2000015773A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122626B2 (en) 2001-04-26 2006-10-17 Genesoft Pharmceuticals, Inc. Halogen-substitued thienyl compounds
US6716866B2 (en) 2001-06-13 2004-04-06 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
AU2002312370A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
WO2002100832A1 (fr) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Composes isoquinoline presentant une activite anti-infectieuse
US6825228B2 (en) 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
AU2003258022A1 (en) 2002-08-02 2004-02-23 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
AU2003285958A1 (en) 2002-10-25 2004-05-25 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
WO2004052304A2 (fr) 2002-12-10 2004-06-24 Oscient Pharmaceuticals Corporation Composes antibacteriens possedant un motif (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide)
WO2007034784A1 (fr) * 2005-09-20 2007-03-29 Nihon University Inhibiteur de l'expression du gène du ctgf
WO2007103584A2 (fr) * 2006-03-09 2007-09-13 Nanovir, Llc Polyamides pour le traitement du virus du papillome humain
WO2007130616A2 (fr) * 2006-05-04 2007-11-15 Nanovir, Llc Polyamides destinés au traitement du papillomavirus humain
US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection
US9982020B2 (en) 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
RU2014113702A (ru) 2011-10-10 2015-11-20 НАНОВИР, ЭлЭлСи Гуанидинил-замещенные полиамиды, пригодные для лечения инфекций, вызванных папилломавирусом человека
US10723716B2 (en) 2016-12-21 2020-07-28 New York University Alpha-helix mimetics as modulators of Abeta self-assembly

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035702A1 (fr) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition de la transcription de genes par des ligands de polyamide se fixant a l'adn
WO1998037067A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Conception, synthese et utilisation de ligands a base de polyamides specifiques pour liaison a l'adn
WO1998037066A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Polyamides ameliores pour assurer une liaison dans le sillon mineur de l'adn a double brins
WO1998049142A1 (fr) * 1997-04-06 1998-11-05 California Institute Of Technology Derives de polyamides pyrrole-imidazole liant l'adn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037067A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Conception, synthese et utilisation de ligands a base de polyamides specifiques pour liaison a l'adn
WO1998037066A1 (fr) * 1996-02-26 1998-08-27 California Institute Of Technology Polyamides ameliores pour assurer une liaison dans le sillon mineur de l'adn a double brins
WO1998035702A1 (fr) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition de la transcription de genes par des ligands de polyamide se fixant a l'adn
WO1998049142A1 (fr) * 1997-04-06 1998-11-05 California Institute Of Technology Derives de polyamides pyrrole-imidazole liant l'adn

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D. M. HERMAN ET AL: "Tandem hairpin motif for recognition in the minor groove of DNA by pyrrole-imidazole polyamides", CHEMISTRY - A EUROPEAN JOURNAL., vol. 5, no. 3, 1999, VCH PUBLISHERS., US, pages 975 - 983, XP002134479, ISSN: 0947-6539 *
D. M.HERMAN ET AL: "Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 7, 25 February 1998 (1998-02-25), DC US, pages 1382 - 1391, XP002077249 *
J.M. TURNER ET AL: "Aliphatic/aronatic amino acid pairings for polyamide recognition in the minor groove of DNA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 25, 1 July 1998 (1998-07-01), DC US, pages 6219 - 6226, XP002134477 *
L. A. DICKINSON ET AL: "Anti-repression of RNA polymerase II transcripion by pyrrole-imidazole polyamides", BIOCHEMISTRY., vol. 38, no. 33, 17 August 1999 (1999-08-17), AMERICAN CHEMICAL SOCIETY. EASTON, PA., US, pages 10801 - 10807, XP002134478, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
CA2342278A1 (fr) 2000-03-23
EP1112267A2 (fr) 2001-07-04
WO2000015773A2 (fr) 2000-03-23
AU5910899A (en) 2000-04-03
JP2003505521A (ja) 2003-02-12

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