CA2341683C - Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto - Google Patents
Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto Download PDFInfo
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- CA2341683C CA2341683C CA2341683A CA2341683A CA2341683C CA 2341683 C CA2341683 C CA 2341683C CA 2341683 A CA2341683 A CA 2341683A CA 2341683 A CA2341683 A CA 2341683A CA 2341683 C CA2341683 C CA 2341683C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0688—Cells from the lungs or the respiratory tract
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9995298P | 1998-09-11 | 1998-09-11 | |
| US60/099,952 | 1998-09-11 | ||
| PCT/US1999/020500 WO2000015246A2 (en) | 1998-09-11 | 1999-09-10 | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2341683A1 CA2341683A1 (en) | 2000-03-23 |
| CA2341683C true CA2341683C (en) | 2015-07-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2341683A Expired - Lifetime CA2341683C (en) | 1998-09-11 | 1999-09-10 | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7691593B2 (enExample) |
| EP (1) | EP1109569A2 (enExample) |
| JP (1) | JP2002524528A (enExample) |
| AU (1) | AU761298C (enExample) |
| CA (1) | CA2341683C (enExample) |
| WO (1) | WO2000015246A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2280736C (en) * | 1997-02-10 | 2012-05-29 | The President And Fellows Of Harvard College | Methods for modulating hematopoiesis and vascular growth |
| US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
| JP2002524528A (ja) * | 1998-09-11 | 2002-08-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法 |
| GB0013674D0 (en) * | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| ES2623711T3 (es) * | 2000-10-13 | 2017-07-12 | Curis, Inc. | Antagonistas de hedgehog, procedimientos y usos relacionados con los mismos |
| US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
| WO2005097207A2 (en) | 2004-03-26 | 2005-10-20 | Curis, Inc. | Rna interference modulators of hedgehog signaling and uses thereof |
| EP2789342A1 (en) | 2004-06-17 | 2014-10-15 | Thrasos Innovation, Inc. | TDF-related compounds and analogs thereof |
| US8299212B2 (en) | 2005-09-20 | 2012-10-30 | Thrasos Therapeutics, Inc. | TDF-related compounds and analogs thereof, analogs and bioactive fragments |
| US8129341B2 (en) | 2008-08-25 | 2012-03-06 | New York University | Methods for treating diabetic wounds |
| WO2010129537A1 (en) * | 2009-05-05 | 2010-11-11 | The Johns Hopkins University | Phosphopeptides as melanoma vaccines |
| WO2011160082A2 (en) | 2010-06-17 | 2011-12-22 | New York University | Therapeutic and cosmetic uses and applications of calreticulin |
| US9814703B2 (en) | 2013-11-14 | 2017-11-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of BMP signaling |
| WO2019048898A1 (en) | 2017-09-05 | 2019-03-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION |
Family Cites Families (30)
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| US6610656B1 (en) * | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
| US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
| US6384192B1 (en) * | 1993-12-30 | 2002-05-07 | President & Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins |
| US6261786B1 (en) * | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
| US7060450B1 (en) * | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
| NZ278765A (en) | 1993-12-30 | 1998-05-27 | Harvard College | Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use |
| US20030186357A1 (en) * | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
| US6884775B1 (en) * | 1993-12-30 | 2005-04-26 | President And Fellows Of Harvard College | Methods and compositions for regulating skeletogenic formation |
| US6165747A (en) * | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
| CA2184092A1 (en) | 1994-02-25 | 1995-08-31 | Thomas M. Jessell | Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof |
| US5681278A (en) * | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
| US6429354B1 (en) * | 1994-10-07 | 2002-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and uses related thereto |
| EP1616942A3 (en) * | 1994-10-07 | 2006-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and their use |
| US6027882A (en) * | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
| US6946257B1 (en) * | 1994-10-07 | 2005-09-20 | Regents Of The University Of California | Patched genes and uses related thereto |
| US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| CA2280736C (en) * | 1997-02-10 | 2012-05-29 | The President And Fellows Of Harvard College | Methods for modulating hematopoiesis and vascular growth |
| US6639051B2 (en) | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
| US6432970B2 (en) * | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP5067986B2 (ja) | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| US6867216B1 (en) * | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
| DE69942063D1 (de) * | 1998-09-11 | 2010-04-08 | Curis Inc | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
| JP2002524528A (ja) * | 1998-09-11 | 2002-08-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法 |
| DE60017157T2 (de) * | 1999-09-16 | 2005-12-22 | Curis, Inc., Cambridge | Vermittler von igel signalwegen, deren zusammenstellungen und verwendungen |
| US6552016B1 (en) * | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US6613798B1 (en) * | 2000-03-30 | 2003-09-02 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| CA2412215A1 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| US7708998B2 (en) * | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
| ES2623711T3 (es) * | 2000-10-13 | 2017-07-12 | Curis, Inc. | Antagonistas de hedgehog, procedimientos y usos relacionados con los mismos |
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1999
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- 1999-09-10 WO PCT/US1999/020500 patent/WO2000015246A2/en not_active Ceased
- 1999-09-10 AU AU62441/99A patent/AU761298C/en not_active Expired
- 1999-09-10 CA CA2341683A patent/CA2341683C/en not_active Expired - Lifetime
- 1999-09-10 EP EP99949603A patent/EP1109569A2/en not_active Withdrawn
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- 2012-08-30 US US13/599,879 patent/US20130085096A1/en not_active Abandoned
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| JP2002524528A (ja) | 2002-08-06 |
| AU6244199A (en) | 2000-04-03 |
| AU761298C (en) | 2005-04-21 |
| US7691593B2 (en) | 2010-04-06 |
| AU761298B2 (en) | 2003-06-05 |
| US20040171546A1 (en) | 2004-09-02 |
| WO2000015246A3 (en) | 2000-07-20 |
| CA2341683A1 (en) | 2000-03-23 |
| US20110124580A1 (en) | 2011-05-26 |
| WO2000015246A9 (en) | 2000-08-24 |
| US20130085096A1 (en) | 2013-04-04 |
| WO2000015246A2 (en) | 2000-03-23 |
| EP1109569A2 (en) | 2001-06-27 |
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