CA2341650A1 - Compositions antibacteriennes carbapenems et methodes de traitement associees - Google Patents

Compositions antibacteriennes carbapenems et methodes de traitement associees Download PDF

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Publication number
CA2341650A1
CA2341650A1 CA002341650A CA2341650A CA2341650A1 CA 2341650 A1 CA2341650 A1 CA 2341650A1 CA 002341650 A CA002341650 A CA 002341650A CA 2341650 A CA2341650 A CA 2341650A CA 2341650 A1 CA2341650 A1 CA 2341650A1
Authority
CA
Canada
Prior art keywords
methyl
groups
substituted
hydroxyethyl
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002341650A
Other languages
English (en)
Inventor
Karen L. Dorso
Charles J. Gill
Jesse J. Jackson
Joyce Kohler
Lynn L. Silver
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2341650A1 publication Critical patent/CA2341650A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne la combinaison de nouveaux agents antibactériens 2-(naphtosultamyl)méthyl-carbapenems ou leurs sels pharmaceutiquement acceptables et d'autres .beta.-lactames. Cette combinaison convient au traitement et à la prévention des infections aux entérocoques et exerce une activité anti-PBP5 ainsi qu'une activité contre les PBP (protéines fixatrices de pénicilline) critiques des isolats sensibles. Par conséquent, ces compositions antibactériennes constituent une contribution importante au traitement des infections dues à ces pathogènes difficiles à éradiquer. Cette combinaison convient également à la lutte contre les micro-organismes Gram positifs, notamment le Staphylococcus aureus résistant à la méthicilline (MRSA), le Staphylococcus epidermidis résistant à la méthicilline (MRSE) et les staphylocoques coagulase-négatifs résistants à la méthicilline (MRCNS).
CA002341650A 1998-09-01 1999-08-31 Compositions antibacteriennes carbapenems et methodes de traitement associees Abandoned CA2341650A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9873898P 1998-09-01 1998-09-01
US60/098,738 1998-09-01
PCT/US1999/020052 WO2000012048A2 (fr) 1998-09-01 1999-08-31 Compositions antibacteriennes carbapenems et methodes de traitement associees

Publications (1)

Publication Number Publication Date
CA2341650A1 true CA2341650A1 (fr) 2000-03-09

Family

ID=22270688

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002341650A Abandoned CA2341650A1 (fr) 1998-09-01 1999-08-31 Compositions antibacteriennes carbapenems et methodes de traitement associees

Country Status (5)

Country Link
EP (1) EP1115419A2 (fr)
JP (1) JP2002525275A (fr)
AU (1) AU6133599A (fr)
CA (1) CA2341650A1 (fr)
WO (1) WO2000012048A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1797879A4 (fr) * 2004-10-08 2009-05-06 Dainippon Sumitomo Pharma Co Nouveau médicament anti-microbien
WO2008085913A1 (fr) * 2007-01-04 2008-07-17 Rib-X Pharmaceuticals, Inc. Procédés pour traiter, prévenir, ou réduire le risque d'infections ophtalmiques, otiques, et nasales
CA2743585C (fr) * 2008-11-12 2017-07-11 Synedgen, Inc. Derives de chitosan seul ou en combinaison pour le traitement d'infections microbiennes mdr
WO2014031892A1 (fr) * 2012-08-22 2014-02-27 Xenoport, Inc. Formes pharmaceutiques orales de fumarate de méthyle-hydrogène et leurs promédicaments
CN116515102A (zh) * 2022-01-21 2023-08-01 苏州万维生命科学技术有限公司 星型β-抗菌糖肽、其制备方法及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW383308B (en) * 1993-08-24 2000-03-01 Hoffmann La Roche 2-beta-alkenyl penam sulfones as beta-lactamase inhibitors
CA2143519A1 (fr) * 1994-03-11 1995-09-12 Markus Bohringer Beta-lactames

Also Published As

Publication number Publication date
JP2002525275A (ja) 2002-08-13
EP1115419A2 (fr) 2001-07-18
AU6133599A (en) 2000-03-21
WO2000012048A3 (fr) 2000-06-22
WO2000012048A2 (fr) 2000-03-09

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Legal Events

Date Code Title Description
FZDE Dead