CA2339094A1 - Antagonistes des recepteurs accepteurs de macrophages - Google Patents

Antagonistes des recepteurs accepteurs de macrophages Download PDF

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Publication number
CA2339094A1
CA2339094A1 CA002339094A CA2339094A CA2339094A1 CA 2339094 A1 CA2339094 A1 CA 2339094A1 CA 002339094 A CA002339094 A CA 002339094A CA 2339094 A CA2339094 A CA 2339094A CA 2339094 A1 CA2339094 A1 CA 2339094A1
Authority
CA
Canada
Prior art keywords
bis
dicarboxamide
hydroxyisophthalic
bromo
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002339094A
Other languages
English (en)
Inventor
Robert G. Franz
Dimitri E. Gaitanopoulos
Gerald R. Girard
Joseph P. Weinstock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2339094A1 publication Critical patent/CA2339094A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'Invention concerne des antagonistes des récepteurs accepteurs de macrophages. L'invention concerne également des méthodes permettant de traiter les maladies cardio-vasculaires, consistant à administrer les composés de l'invention qui inhibent l'accumulation des lipides dans les cellules spumeuses dérivées des macrophages.
CA002339094A 1998-07-30 1999-07-30 Antagonistes des recepteurs accepteurs de macrophages Abandoned CA2339094A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9463598P 1998-07-30 1998-07-30
US60/094,635 1998-07-30
US9505998P 1998-08-03 1998-08-03
US60/095,059 1998-08-03
PCT/US1999/017166 WO2000006147A1 (fr) 1998-07-30 1999-07-30 Antagonistes des recepteurs accepteurs de macrophages

Publications (1)

Publication Number Publication Date
CA2339094A1 true CA2339094A1 (fr) 2000-02-10

Family

ID=26789097

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339094A Abandoned CA2339094A1 (fr) 1998-07-30 1999-07-30 Antagonistes des recepteurs accepteurs de macrophages

Country Status (4)

Country Link
EP (1) EP1100486A4 (fr)
JP (1) JP2002521437A (fr)
CA (1) CA2339094A1 (fr)
WO (1) WO2000006147A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001264286A1 (en) * 2000-06-16 2001-12-24 Chugai Seiyaku Kabushiki Kaisha Preventives/remedies for granuloma
IL157444A0 (en) 2001-02-23 2004-03-28 Bristol Myers Squibb Pharma Co Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same
CN105669487A (zh) * 2016-03-01 2016-06-15 重庆大学 一种温和条件下脱除酚羟基甲基保护基的方法
JP7072213B2 (ja) 2017-12-21 2022-05-20 国立研究開発法人理化学研究所 Ｂ型肝炎抗原タンパク質を標的としたイメージング用ｐｅｔプローブ
WO2020255425A1 (fr) * 2019-06-21 2020-12-24 国立研究開発法人理化学研究所 Agent anti-vhb

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH459172A (de) * 1961-09-11 1968-07-15 Wander Ag Dr A Verfahren zur Herstellung mehrbasischer Verbindungen

Also Published As

Publication number Publication date
JP2002521437A (ja) 2002-07-16
EP1100486A1 (fr) 2001-05-23
EP1100486A4 (fr) 2003-01-15
WO2000006147A1 (fr) 2000-02-10

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Legal Events

Date Code Title Description
FZDE Dead