CA2339088A1 - Compositions et procedes servant a identifier des inhibiteurs, agonistes et antagonistes de malonyle coa decarboxylase mammifere - Google Patents

Compositions et procedes servant a identifier des inhibiteurs, agonistes et antagonistes de malonyle coa decarboxylase mammifere Download PDF

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Publication number
CA2339088A1
CA2339088A1 CA002339088A CA2339088A CA2339088A1 CA 2339088 A1 CA2339088 A1 CA 2339088A1 CA 002339088 A CA002339088 A CA 002339088A CA 2339088 A CA2339088 A CA 2339088A CA 2339088 A1 CA2339088 A1 CA 2339088A1
Authority
CA
Canada
Prior art keywords
mcd
malonyl coa
activity
coa
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002339088A
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English (en)
Inventor
Gary D. Lopaschuk
Jason Dyck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2339088A1 publication Critical patent/CA2339088A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne le domaine de l'oxydation des acides gras, des compositions et des procédés servant à identifier et à tester des inhibiteurs d'oxydation d'acides gras et, en particulier, des compositions contenant une nouvelle isoforme cardiaque de MCD, identifiée en tant que régulateur clé de l'oxydation des acides gras dans le coeur. Elle concerne, de plus, des séquences acides de nucléotides de gènes de malonyle CoA décarboxylase provenant du pancréas, du coeur et du foie du rat. Ces séquences et les produits dérivés sont utiles dans des procédés de criblage servant à identifier et à tester des agonistes et des antagonistes du trajet de MCD.
CA002339088A 1998-08-11 1999-08-09 Compositions et procedes servant a identifier des inhibiteurs, agonistes et antagonistes de malonyle coa decarboxylase mammifere Abandoned CA2339088A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9609398P 1998-08-11 1998-08-11
US60/096,093 1998-08-11
US25120099A 1999-02-16 1999-02-16
US09/251,200 1999-02-16
PCT/CA1999/000734 WO2000009710A2 (fr) 1998-08-11 1999-08-09 Compositions et procedes servant a identifier des inhibiteurs, agonistes et antagonistes de malonyle coa decarboxylase mammifere

Publications (1)

Publication Number Publication Date
CA2339088A1 true CA2339088A1 (fr) 2000-02-24

Family

ID=26791076

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339088A Abandoned CA2339088A1 (fr) 1998-08-11 1999-08-09 Compositions et procedes servant a identifier des inhibiteurs, agonistes et antagonistes de malonyle coa decarboxylase mammifere

Country Status (6)

Country Link
EP (1) EP1127139A2 (fr)
JP (1) JP2002522082A (fr)
KR (1) KR20010085373A (fr)
AU (1) AU774628B2 (fr)
CA (1) CA2339088A1 (fr)
WO (1) WO2000009710A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1370260T1 (sl) * 2001-02-20 2011-02-28 Chugai Pharmaceutical Co Ltd Azoli kot inhibitorji malonil-CoA dekarboksilaze, uporabni kot metabolični modulatorji
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
AU2003248558B8 (en) * 2002-05-21 2009-07-09 Gilead Sciences, Inc. Method of treating diabetes
US7285562B2 (en) 2003-08-01 2007-10-23 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-CoA decarboxylase inhibitors
WO2005011670A1 (fr) 2003-08-01 2005-02-10 Chugai Seiyaku Kabushiki Kaisha Composes heterocycliques utiles comme inhibiteurs de la malonyl-coa decarboxylase
ATE400272T1 (de) 2003-08-01 2008-07-15 Chugai Pharmaceutical Co Ltd Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer
JP4773960B2 (ja) 2003-08-01 2011-09-14 中外製薬株式会社 マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用なシアノグアニジン型アゾール化合物
WO2008106630A1 (fr) * 2007-03-01 2008-09-04 Bristol-Myers Squibb Company Essai enzymatique couplé pour mesurer l'activité de l'acétyl-coa-carboxylase et la malonyl-coa-décarboxylase
CN115161380A (zh) * 2022-06-21 2022-10-11 亚科因(武汉)生物技术有限公司 α-酮戊二酸脱氢酶检测试剂盒及其应用

Also Published As

Publication number Publication date
AU774628B2 (en) 2004-07-01
AU5272999A (en) 2000-03-06
WO2000009710A3 (fr) 2001-06-07
JP2002522082A (ja) 2002-07-23
EP1127139A2 (fr) 2001-08-29
WO2000009710A2 (fr) 2000-02-24
KR20010085373A (ko) 2001-09-07

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