CA2338766A1 - Cryogranulation de la proteine c activee - Google Patents

Cryogranulation de la proteine c activee Download PDF

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Publication number
CA2338766A1
CA2338766A1 CA002338766A CA2338766A CA2338766A1 CA 2338766 A1 CA2338766 A1 CA 2338766A1 CA 002338766 A CA002338766 A CA 002338766A CA 2338766 A CA2338766 A CA 2338766A CA 2338766 A1 CA2338766 A1 CA 2338766A1
Authority
CA
Canada
Prior art keywords
apc
solution
protein
activated protein
cryogranules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002338766A
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Nancy Delores Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2338766A1 publication Critical patent/CA2338766A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4866—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un procédé de transformation d'une solution aqueuse de la protéine C dans un état approprié pour le stockage, la manipulation et la récupération. L'invention concerne des solutions aqueuses de la protéine C activée et un procédé amélioré de transformation de telles solutions en cryogranules.
CA002338766A 1998-07-31 1999-07-26 Cryogranulation de la proteine c activee Abandoned CA2338766A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9496998P 1998-07-31 1998-07-31
US60/094,969 1998-07-31
PCT/US1999/016937 WO2000006179A1 (fr) 1998-07-31 1999-07-26 Cryogranulation de la proteine c activee

Publications (1)

Publication Number Publication Date
CA2338766A1 true CA2338766A1 (fr) 2000-02-10

Family

ID=22248239

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002338766A Abandoned CA2338766A1 (fr) 1998-07-31 1999-07-26 Cryogranulation de la proteine c activee

Country Status (5)

Country Link
EP (1) EP1140121A4 (fr)
JP (1) JP2003506006A (fr)
AU (1) AU5131699A (fr)
CA (1) CA2338766A1 (fr)
WO (1) WO2000006179A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6753790A (en) 1989-11-17 1991-06-13 Alan Joseph Green Dental floss applicators
AUPR750501A0 (en) * 2001-09-05 2001-09-27 Gauci, Mark Products comprising quantum of bioparticles and method for production thereof
JP4755992B2 (ja) * 2003-12-19 2011-08-24 アルク−アベッロ エイ／エス 有効医薬成分の寒冷顆粒化及び貯蔵の方法
BRPI0417264A (pt) * 2003-12-19 2007-03-06 Alk Abello As processos para a preparação de uma batelada de um ingrediente farmacêutico ativo, um recipiente compreendendo criogránulos de um produto alérgeno, e um criogránulo de um produto alérgeno
EP2403471A2 (fr) * 2009-03-06 2012-01-11 Linde AG Procédé de fabrication de cosmétiques
SG10201406835XA (en) 2009-11-02 2014-11-27 Mannkind Corp Apparatus And Method For Cryogranulating A Pharmaceutical Composition
PT2879666T (pt) * 2012-08-01 2020-05-07 Tavakoli Zahra Composições congeladas, de fluxo livre contendo um agente terapêutico

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives

Also Published As

Publication number Publication date
EP1140121A4 (fr) 2004-07-14
AU5131699A (en) 2000-02-21
WO2000006179A1 (fr) 2000-02-10
EP1140121A1 (fr) 2001-10-10
JP2003506006A (ja) 2003-02-18

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued