CA2336363A1 - Processus de fermentation visant la production d'acide clavulanique a faible concentration d'acides amines libres - Google Patents

Processus de fermentation visant la production d'acide clavulanique a faible concentration d'acides amines libres Download PDF

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Publication number
CA2336363A1
CA2336363A1 CA002336363A CA2336363A CA2336363A1 CA 2336363 A1 CA2336363 A1 CA 2336363A1 CA 002336363 A CA002336363 A CA 002336363A CA 2336363 A CA2336363 A CA 2336363A CA 2336363 A1 CA2336363 A1 CA 2336363A1
Authority
CA
Canada
Prior art keywords
clavulanic acid
fermentation
amino acids
free amino
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002336363A
Other languages
English (en)
Inventor
Wilhelmus Theodorus Antonius Maria De Laat
Preben Krabben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2336363A1 publication Critical patent/CA2336363A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un procédé amélioré visant la production de métabolites secondaires par la fermentation d'une souche de Streptomyces. Si la concentration d'acides aminés libres reste faible, on obtient un rendement étonnamment élevé.
CA002336363A 1998-07-03 1999-07-01 Processus de fermentation visant la production d'acide clavulanique a faible concentration d'acides amines libres Abandoned CA2336363A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202264.2 1998-07-03
EP98202264 1998-07-03
PCT/EP1999/004702 WO2000001840A1 (fr) 1998-07-03 1999-07-01 Processus de fermentation visant la production d'acide clavulanique a faible concentration d'acides amines libres

Publications (1)

Publication Number Publication Date
CA2336363A1 true CA2336363A1 (fr) 2000-01-13

Family

ID=8233894

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002336363A Abandoned CA2336363A1 (fr) 1998-07-03 1999-07-01 Processus de fermentation visant la production d'acide clavulanique a faible concentration d'acides amines libres

Country Status (7)

Country Link
EP (1) EP1097238A1 (fr)
CN (1) CN1308682A (fr)
AU (1) AU5409799A (fr)
CA (1) CA2336363A1 (fr)
MX (1) MXPA00012930A (fr)
TR (1) TR200003828T2 (fr)
WO (1) WO2000001840A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1122305A1 (fr) * 2000-01-31 2001-08-08 Dsm N.V. Streptomyces clavuligerus transformé par la glutamate déshydrogénase présentant une capacité améliorée d'assimiler de l'ammoniac
WO2009138994A1 (fr) * 2008-05-14 2009-11-19 Biocon Limited Procédé de fermentation pour la fabrication de métabolites secondaires
KR101723167B1 (ko) * 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
KR101729251B1 (ko) * 2015-04-28 2017-04-21 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
CN105817190B (zh) * 2016-03-15 2019-01-08 浙江凯色丽科技发展有限公司 水解自动化控制系统
CN111944734B (zh) * 2019-05-17 2023-01-10 中国科学院微生物研究所 提高链霉菌聚酮化合物产量的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
FR2368276A1 (fr) * 1975-02-07 1978-05-19 Glaxo Lab Ltd Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use

Also Published As

Publication number Publication date
TR200003828T2 (tr) 2001-06-21
EP1097238A1 (fr) 2001-05-09
MXPA00012930A (es) 2002-05-08
CN1308682A (zh) 2001-08-15
WO2000001840A1 (fr) 2000-01-13
AU5409799A (en) 2000-01-24

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20030702