CA2332573A1 - Genes mammiferes ; transporteur du type prostaglandine de cellules dendritiques (dc-pgt), hdtea84, hsljd37r et rankl, chimiokine hcc5, proteines de desubiquitination 11 et 12 (dub11, dub12), md-1, md-2 et cycline e2, reactifs apparentes et procedes associes - Google Patents

Genes mammiferes ; transporteur du type prostaglandine de cellules dendritiques (dc-pgt), hdtea84, hsljd37r et rankl, chimiokine hcc5, proteines de desubiquitination 11 et 12 (dub11, dub12), md-1, md-2 et cycline e2, reactifs apparentes et procedes associes Download PDF

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Publication number
CA2332573A1
CA2332573A1 CA002332573A CA2332573A CA2332573A1 CA 2332573 A1 CA2332573 A1 CA 2332573A1 CA 002332573 A CA002332573 A CA 002332573A CA 2332573 A CA2332573 A CA 2332573A CA 2332573 A1 CA2332573 A1 CA 2332573A1
Authority
CA
Canada
Prior art keywords
polypeptide
seq
sequence
primate
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002332573A
Other languages
English (en)
Inventor
Elizabeth Esther Mary Bates
Serge J. E. Lebecque
Erin E. Murphy
Jeanine D. Mattson
Daniel M. Gorman
Joseph A. Hedrick
Luquan Wang
Albert Zlotnik
Nicholas J. Murgolo
Jonathan R. Greene
James A. Johnston
Jose Fernando Bazan
Daniel Mahony
Emma M. Lees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2332573A1 publication Critical patent/CA2332573A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

L'invention concerne des gènes purifiés, provenant d'un mammifère, des réactifs apparentés à ces gènes, notamment des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant ces polypeptides. L'invention concerne encore des procédés d'utilisation de ces réactifs, ainsi que des nécessaires de diagnostic. Elle caractérise enfin des gènes et des produits associés à DC-PGT (transporteur du type prostaglandine de cellules dendritiques), HDTEA84, HSLJD37R et RANKL (associés à la famille des récepteurs de TNF), chimiokine HCC5, Dub 11 et Dub 12 (protéines de désubiquitination 11 et 12), MD-1 et MD-2 (protéines possédant des propriétés de ligands de protéines présentant un motif de protéine riche en leucines (LRR)) et cycline E2.
CA002332573A 1998-07-06 1999-07-06 Genes mammiferes ; transporteur du type prostaglandine de cellules dendritiques (dc-pgt), hdtea84, hsljd37r et rankl, chimiokine hcc5, proteines de desubiquitination 11 et 12 (dub11, dub12), md-1, md-2 et cycline e2, reactifs apparentes et procedes associes Abandoned CA2332573A1 (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US11093898A 1998-07-06 1998-07-06
US09/110,938 1998-07-06
US11446698A 1998-07-13 1998-07-13
US09/114,466 1998-07-13
US9389798P 1998-07-23 1998-07-23
US60/093,897 1998-07-23
US13296898A 1998-08-12 1998-08-12
US09/132,968 1998-08-12
US13621498A 1998-08-18 1998-08-18
US09/136,214 1998-08-18
US9999998P 1998-09-11 1998-09-11
US60/099,999 1998-09-11
PCT/US1999/012366 WO2000001817A2 (fr) 1998-07-06 1999-07-06 Genes mammiferes ; transporteur du type prostaglandine de cellules dendritiques (dc-pgt), hdtea84, hsljd37r et rankl, chimiokine hcc5, proteines de desubiquitination 11 et 12 (dub11, dub12), md-1, md-2 et cycline e2, reactifs apparentes et procedes associes

Publications (1)

Publication Number Publication Date
CA2332573A1 true CA2332573A1 (fr) 2000-01-13

Family

ID=27557472

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002332573A Abandoned CA2332573A1 (fr) 1998-07-06 1999-07-06 Genes mammiferes ; transporteur du type prostaglandine de cellules dendritiques (dc-pgt), hdtea84, hsljd37r et rankl, chimiokine hcc5, proteines de desubiquitination 11 et 12 (dub11, dub12), md-1, md-2 et cycline e2, reactifs apparentes et procedes associes

Country Status (5)

Country Link
EP (1) EP1093516A2 (fr)
JP (1) JP2002519062A (fr)
AU (1) AU4818599A (fr)
CA (1) CA2332573A1 (fr)
WO (1) WO2000001817A2 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5802798A (en) 1996-12-20 1998-07-17 Human Genome Sciences, Inc. Human oncogene induced secreted protein i
ATE365796T1 (de) 1997-01-14 2007-07-15 Human Genome Sciences Inc Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
EP1012179A2 (fr) 1997-09-12 2000-06-28 Apotech R&D S.A. Recepteurs "trail" riches en cysteine
WO1999018205A1 (fr) * 1997-10-07 1999-04-15 Ono Pharmaceutical Co., Ltd. POLYPEPTIDE, ADNc LE CODANT ET LEUR UTILISATION
WO2000026245A2 (fr) * 1998-11-04 2000-05-11 Incyte Pharmaceuticals, Inc. Proteines de transport membranaire
AU2486300A (en) * 1998-12-30 2000-07-31 Millennium Pharmaceuticals, Inc. Secreted proteins and nucleic acids encoding them
IL145676A0 (en) 1999-04-12 2002-06-30 Genentech Inc Tumor necrosis factor homologs and nucleic acids encoding the same
JP2003503052A (ja) * 1999-06-23 2003-01-28 アンジオジーン インコーポレイテッド サイクリンｅ遺伝子発現を調節するアンチセンスオリゴヌクレオチドおよび治療でのその使用
US6951738B2 (en) 1999-07-16 2005-10-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
US6329171B1 (en) 1999-09-30 2001-12-11 Millennium Pharmaceuticals, Inc. 23484, A novel human ubiquitin protease
US7329529B2 (en) 1999-09-03 2008-02-12 Millennium Pharmaceuticals, Inc. Ubiqutin proteases
DE60042220D1 (de) * 1999-09-21 2009-06-25 Chugai Pharmaceutical Co Ltd Verwendung vom transportergen oatp-c zur screening von testsubstanzen
US6451994B1 (en) 1999-09-27 2002-09-17 Millennium Pharmaceuticals, Inc. 23413, a novel human ubiquitin protease
US7029895B2 (en) 1999-09-27 2006-04-18 Millennium Pharmaceuticals, Inc. 27411, a novel human PGP synthase
CA2391820A1 (fr) * 1999-10-22 2001-05-03 Zymogenetics, Inc. Polypeptides umlr
AU2002219083A1 (en) * 2000-11-09 2002-05-21 Bayer Aktiengesellschaft Regulation of human oat-like protein
US6900044B2 (en) 2001-03-27 2005-05-31 Millennium Pharmaceutical, Inc. 68999, a human ubiquitin carboxyl-terminal hydrolase family member and uses therefor
WO2003013583A1 (fr) * 2001-08-10 2003-02-20 Genset S.A. Agonistes et antagonistes de faxigene dans le traitement de troubles metaboliques
BR0307895A (pt) * 2002-02-22 2006-01-17 Aventis Pharma Inc Análogos humanos dos genes murinos da protease de desubiquitinação
GB0218518D0 (en) 2002-03-22 2002-09-18 Aventis Pharma Inc Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
WO2005049818A2 (fr) * 2003-11-14 2005-06-02 The Queen's University Of Belfast Gene
US7312320B2 (en) 2003-12-10 2007-12-25 Novimmune Sa Neutralizing antibodies and methods of use thereof
US7674884B2 (en) * 2003-12-10 2010-03-09 Novimmune S.A. Neutralizing antibodies and methods of use thereof
GB0412186D0 (en) * 2004-05-28 2004-06-30 Univ Cambridge Tech Production of recombinant protein
US7846438B2 (en) 2004-08-03 2010-12-07 Biogen Idec Ma Inc. Methods of promoting neurite outgrowth with soluble TAJ polypeptides
EP2776066B1 (fr) 2011-11-07 2018-09-19 Universite Laval Antagonistes de rank/rankl pour l'utilisation dans le traitement de troubles neuromusculaires, de myopathies génétiques et/ou de myopathies non génétiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ271756A (en) * 1993-12-22 1998-02-26 Human Genome Sciences Inc Human macrophage inflammatory proteins and coding sequences, their production and use
MX9708537A (es) * 1995-05-05 1998-02-28 Human Genome Sciences Inc Quimiocina beta-8 quimiocina beta-1 y proteina-4 inflamatoria de los macrofagos, humanas.
US5792851A (en) * 1996-09-03 1998-08-11 Albert Einstin College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Human prostaglandin transporter

Also Published As

Publication number Publication date
JP2002519062A (ja) 2002-07-02
WO2000001817A3 (fr) 2000-06-29
EP1093516A2 (fr) 2001-04-25
WO2000001817A2 (fr) 2000-01-13
AU4818599A (en) 2000-01-24

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