CA2331332A1 - Anti-angiogenic proteins and methods of use thereof - Google Patents
Anti-angiogenic proteins and methods of use thereof Download PDFInfo
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- CA2331332A1 CA2331332A1 CA002331332A CA2331332A CA2331332A1 CA 2331332 A1 CA2331332 A1 CA 2331332A1 CA 002331332 A CA002331332 A CA 002331332A CA 2331332 A CA2331332 A CA 2331332A CA 2331332 A1 CA2331332 A1 CA 2331332A1
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- protein
- cells
- angiogenic
- fragment
- tumstatin
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Genetics & Genomics (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8968998P | 1998-06-17 | 1998-06-17 | |
US60/089,689 | 1998-06-17 | ||
US12617599P | 1999-03-25 | 1999-03-25 | |
US60/126,175 | 1999-03-25 | ||
PCT/US1999/013737 WO1999065940A1 (en) | 1998-06-17 | 1999-06-17 | Anti-angiogenic proteins and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
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CA2331332A1 true CA2331332A1 (en) | 1999-12-23 |
Family
ID=26780845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002331332A Abandoned CA2331332A1 (en) | 1998-06-17 | 1999-06-17 | Anti-angiogenic proteins and methods of use thereof |
Country Status (8)
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440729B1 (en) | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
US6358735B1 (en) | 1995-06-30 | 2002-03-19 | University Of Kansas Medical Center | Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
JP2003519630A (ja) * | 2000-01-07 | 2003-06-24 | ベス イスラエル ディーコネス メディカル センター | 抗血管新生タンパク質およびその断片ならびに使用方法 |
EP1171602A1 (en) * | 2000-02-10 | 2002-01-16 | ZymoGenetics, Inc. | Anti-angiogenic intestinal peptides, zdint5 |
ES2454640T3 (es) | 2000-08-03 | 2014-04-11 | Johns Hopkins University | Vacuna molecular que lleva unida un polipéptido de chaperona del retículo endoplasmático a un antígeno |
JP2004517117A (ja) | 2001-01-05 | 2004-06-10 | バイロメッド・リミテッド | 抗血管新生タンパク質をコードする遺伝子またはその部分を含む慢性関節リウマチ治療用医薬組成物 |
EP1389997B1 (en) * | 2001-04-13 | 2010-12-08 | Boyce Thompson Institute For Plant Research | Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives |
CN100447155C (zh) * | 2001-05-23 | 2008-12-31 | 中国科学院上海上海生命科学研究院 | 具有抑制内皮细胞生长活性的重组人内皮生长抑制蛋白 |
AU2002329643B2 (en) * | 2001-07-27 | 2006-11-16 | University Of Kansas Medical Center | Crystallized structure of type IV collagen NC1 domain hexamer |
EP1644048B1 (en) | 2003-05-05 | 2015-04-29 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
CA2594040A1 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
JP4843767B2 (ja) * | 2005-08-31 | 2011-12-21 | 国立大学法人 岡山大学 | がん細胞特異的遺伝子発現法を用いた血管新生阻害薬 |
US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
CN101962404A (zh) * | 2010-06-17 | 2011-02-02 | 中国热带农业科学院热带生物技术研究所 | 一种用于治疗血管瘤的蛋白质 |
PT2744831T (pt) * | 2011-08-17 | 2018-03-05 | Univ Colorado Regents | Proteína de fusão de transferrina-tumstatina e métodos para a produzir e utilizar |
DK2995626T3 (en) * | 2013-05-06 | 2018-10-29 | Univ China Pharma | BIFUNCTIONAL FUSION PROTEINS TO INHIBIT ANGIOGENESIS IN TUMOR ENVIRONMENTS AND ACTIVATE ADAPTIVE IMMUNE RESPONSE, AND THE GENES AND APPLICATIONS THEREOF |
CN111087477B (zh) * | 2020-01-03 | 2021-10-08 | 四川大学华西医院 | GBM-7S(α1)-NC1(α3)融合蛋白及其制备方法 |
CN113735966B (zh) * | 2021-09-29 | 2022-11-01 | 陕西巨子生物技术有限公司 | 一种抗肿瘤重组胶原蛋白及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4876332A (en) * | 1987-10-08 | 1989-10-24 | Regents Of The Univeristy Of Minnesota | Polypeptides with type IV collagen activity |
US5354690A (en) * | 1989-07-07 | 1994-10-11 | Karl Tryggvason | Immunological methods for the detection of the human type IV collagen α5 chain |
US5114840A (en) * | 1989-07-07 | 1992-05-19 | Karl Tryggvason | Method for determining the nucleotide sequence of a novel α5(IV) chain of human type IV collagen |
US5081031A (en) * | 1989-12-14 | 1992-01-14 | Regents Of The University Of Minnesota | Synthetic polypeptide with type iv collagen activity |
US5082926A (en) * | 1989-12-14 | 1992-01-21 | Regents Of The University Of Minnesota | Polypeptide with type iv collagen cell adhesion, spreading and motility activity |
US5424408A (en) * | 1990-11-30 | 1995-06-13 | Yale University | α-3 chain type IV collagen polynucleotides |
US5731192A (en) * | 1993-08-27 | 1998-03-24 | Yale University | Collagen COL4A6: gene, protein and method of detecting collagen deficiency |
US5567609A (en) * | 1994-06-30 | 1996-10-22 | University Of Kansas Medical Center | Use of isolated domains of type IV collagen to modify cell and tissue interactions |
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1999
- 1999-06-17 JP JP2000554765A patent/JP2002517999A/ja not_active Ceased
- 1999-06-17 AU AU45755/99A patent/AU753249B2/en not_active Ceased
- 1999-06-17 IL IL14023999A patent/IL140239A0/xx unknown
- 1999-06-17 CN CN99808686A patent/CN1309663A/zh active Pending
- 1999-06-17 CA CA002331332A patent/CA2331332A1/en not_active Abandoned
- 1999-06-17 EP EP99928762A patent/EP1086129A1/en not_active Ceased
- 1999-06-17 WO PCT/US1999/013737 patent/WO1999065940A1/en active IP Right Grant
- 1999-06-17 KR KR1020007014426A patent/KR100682666B1/ko not_active IP Right Cessation
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2007
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2008
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Also Published As
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KR100682666B1 (ko) | 2007-02-15 |
JP2008019271A (ja) | 2008-01-31 |
CN1309663A (zh) | 2001-08-22 |
AU753249B2 (en) | 2002-10-10 |
JP2008301823A (ja) | 2008-12-18 |
IL140239A0 (en) | 2002-02-10 |
JP2002517999A (ja) | 2002-06-25 |
KR20010053018A (ko) | 2001-06-25 |
WO1999065940A1 (en) | 1999-12-23 |
AU4575599A (en) | 2000-01-05 |
EP1086129A1 (en) | 2001-03-28 |
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EEER | Examination request | ||
FZDE | Discontinued |