CA2330558A1 - Derives de l'acide (2-acylaminothiazole-4-yl)acetique - Google Patents

Derives de l'acide (2-acylaminothiazole-4-yl)acetique Download PDF

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Publication number
CA2330558A1
CA2330558A1 CA002330558A CA2330558A CA2330558A1 CA 2330558 A1 CA2330558 A1 CA 2330558A1 CA 002330558 A CA002330558 A CA 002330558A CA 2330558 A CA2330558 A CA 2330558A CA 2330558 A1 CA2330558 A1 CA 2330558A1
Authority
CA
Canada
Prior art keywords
amino
oxo
thiazoleacetic acid
octadecenyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002330558A
Other languages
English (en)
Inventor
Kenneth Lewis Kees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2330558A1 publication Critical patent/CA2330558A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Abstract

La présente invention concerne des composés de formule (I) de structure (I), dans laquelle R?1¿, R?2¿ sont tous les deux des hydrogènes ou forment une liaison, ou sont chacun, de manière indépendante, un alkyle en C¿1?-C¿6? ou un aryle en C¿6?-C¿12?; m prend la valeur de 0 à 10, n prend la valeur de 1 à 3, et p prend la valeur de 0 à 10 ; avec la condition que la somme m+p soit inférieure ou égale à 15. Ces composés ou leurs sels acceptables sur le plan pharmaceutique sont utiles dans le traitement de la résistance insulinique et de l'hyperglycémie.
CA002330558A 1998-05-12 1999-05-10 Derives de l'acide (2-acylaminothiazole-4-yl)acetique Abandoned CA2330558A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7670898A 1998-05-12 1998-05-12
US09/076,708 1998-05-12
PCT/US1999/010212 WO1999058514A1 (fr) 1998-05-12 1999-05-10 Derives de l'acide (2-acylaminothiazole-4-yl)acetique

Publications (1)

Publication Number Publication Date
CA2330558A1 true CA2330558A1 (fr) 1999-11-18

Family

ID=22133723

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002330558A Abandoned CA2330558A1 (fr) 1998-05-12 1999-05-10 Derives de l'acide (2-acylaminothiazole-4-yl)acetique

Country Status (6)

Country Link
EP (1) EP1077960A1 (fr)
JP (1) JP2002514633A (fr)
CN (1) CN1308619A (fr)
AU (1) AU3791899A (fr)
CA (1) CA2330558A1 (fr)
WO (1) WO1999058514A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1331327A (zh) * 2000-06-26 2002-01-16 上海博德基因开发有限公司 一种新的多肽——人纹状体富集磷酸酶14.85和编码这种多肽的多核苷酸
EP1452530A4 (fr) 2001-12-03 2005-11-30 Japan Tobacco Inc Compose azole et utilisation medicinale de celui-ci
MXPA05010945A (es) * 2003-04-09 2005-11-25 Japan Tobacco Inc Compuesto pentaciclico heteroaromatico y uso medicinal del mismo.
BRPI0409447A (pt) * 2003-04-14 2006-04-18 Inst For Pharm Discovery Inc ácidos fenilalcanóicos substituìdos
JP2006525329A (ja) 2003-04-30 2006-11-09 ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー 置換カルボン酸類
WO2005035551A2 (fr) 2003-10-08 2005-04-21 Incyte Corporation Inhibiteurs de proteines se liant a des molecules phosphorylees
CN1946703A (zh) 2004-04-20 2007-04-11 特兰斯泰克制药公司 取代的噻唑和嘧啶衍生物作为黑素细胞皮质激素受体调节剂
CN101260086B (zh) * 2007-03-06 2011-08-10 中国科学院上海药物研究所 蛋白酪氨酸磷酸酯酶1b抑制剂及其制备方法和用途
WO2010025142A1 (fr) 2008-08-29 2010-03-04 Transtech Pharma, Inc. Dérivés d'aminothiazole substitués, compositions pharmaceutiques et leurs procédés d'utilisation
CN102408417B (zh) * 2011-09-26 2015-03-11 上海交通大学 2-取代乙烯磺酸酯类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856347A (en) * 1994-11-29 1999-01-05 Hisamitsu Pharmaceutical Co., Inc. Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof
US5688821A (en) * 1995-12-12 1997-11-18 American Home Products Corporation Unsaturated fatty acyl derivatives of 2-aminothiazoleacetic acid and their salts as inhibitors of phospholipase A2 derived from human sources
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use

Also Published As

Publication number Publication date
JP2002514633A (ja) 2002-05-21
AU3791899A (en) 1999-11-29
WO1999058514A1 (fr) 1999-11-18
EP1077960A1 (fr) 2001-02-28
CN1308619A (zh) 2001-08-15

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