CA2329868A1 - Compounds, screening methods, and uses involving anti-apoptotic genes and gene products - Google Patents
Compounds, screening methods, and uses involving anti-apoptotic genes and gene products Download PDFInfo
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- CA2329868A1 CA2329868A1 CA002329868A CA2329868A CA2329868A1 CA 2329868 A1 CA2329868 A1 CA 2329868A1 CA 002329868 A CA002329868 A CA 002329868A CA 2329868 A CA2329868 A CA 2329868A CA 2329868 A1 CA2329868 A1 CA 2329868A1
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5035—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on sub-cellular localization
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
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- G01N2510/00—Detection of programmed cell death, i.e. apoptosis
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
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- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
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- Pathology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US09/080,265 | 1998-05-18 | ||
| US09/080,265 US6218511B1 (en) | 1998-05-18 | 1998-05-18 | Anti-apoptotic genes of human cytomegalovirus (HCMV) and their use |
| US30112199A | 1999-04-28 | 1999-04-28 | |
| US09/301,121 | 1999-04-28 | ||
| PCT/US1999/006567 WO1999060171A1 (en) | 1998-05-18 | 1999-05-06 | Compounds, screening methods, and uses involving anti-apoptotic genes and gene products |
Publications (1)
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|---|---|
| CA2329868A1 true CA2329868A1 (en) | 1999-11-25 |
Family
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| CA002329868A Abandoned CA2329868A1 (en) | 1998-05-18 | 1999-05-06 | Compounds, screening methods, and uses involving anti-apoptotic genes and gene products |
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| US (4) | US6605426B1 (enExample) |
| EP (1) | EP1080233A4 (enExample) |
| JP (1) | JP2002515267A (enExample) |
| AU (1) | AU762756B2 (enExample) |
| CA (1) | CA2329868A1 (enExample) |
| NZ (1) | NZ507426A (enExample) |
| WO (1) | WO1999060171A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112816637A (zh) * | 2020-06-17 | 2021-05-18 | 湖南慧泽生物医药科技有限公司 | 一种吗替麦考酚酯片的体外溶出方法 |
Families Citing this family (38)
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| EP1084260B1 (en) * | 1998-06-02 | 2007-11-28 | Vertex Pharmaceuticals Incorporated | Caspase-9 deficient animals and the use thereof |
| US6465187B1 (en) * | 2000-05-08 | 2002-10-15 | Innoventus Project Ab | Method of treatment |
| AU2001266070A1 (en) * | 2000-06-16 | 2001-12-24 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for identifying apoptosis-modified proteins |
| EP1164374A1 (en) * | 2000-06-16 | 2001-12-19 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for identifying apoptosis-modified proteins |
| WO2002052032A1 (fr) * | 2000-12-22 | 2002-07-04 | Chugai Seiyaku Kabushiki Kaisha | Procede servant a mesurer la mort cellulaire de cellules ciblees |
| US20030219795A1 (en) * | 2002-03-01 | 2003-11-27 | Marcia Belvin | SCDs as modifiers of the p53 pathway and methods of use |
| AU2003275304A1 (en) * | 2002-10-01 | 2004-04-23 | Musc Oundation For Research Development | Use of caspase inhibitors as therapeutic agent against radiation-induced injury |
| AU2003297281A1 (en) * | 2002-11-15 | 2004-06-15 | Chao, Wei | Methods for treating, preventing, or reducing cardiac disorders using fadd inhibitors |
| US7632972B2 (en) * | 2003-10-30 | 2009-12-15 | The Board Of Trustees Of The University Of Illionis | Compounds and methods for treatment of cancer and modulation of programmed cell death for melanoma and other cancer cells |
| KR100677114B1 (ko) * | 2004-04-27 | 2007-02-02 | 삼성전자주식회사 | 정보 저장 매체, 이 정보 저장 매체의 데이터 기록/재생방법 및 장치 |
| US7894174B2 (en) * | 2004-08-23 | 2011-02-22 | Monolithic Power Systems, Inc. | Method and apparatus for fault detection scheme for cold cathode fluorescent lamp (CCFL) integrated circuits |
| WO2008134474A2 (en) | 2007-04-27 | 2008-11-06 | The Board Of Trustees Of The University Of Illinois | Compositions and methods including cell death inducers and procaspase activation |
| MX2008014712A (es) | 2006-05-19 | 2009-03-20 | Univ Illinois | Compuestos que contienen fosforo que incluyen esteres de trifenilmetilfosfonato para el tratamiento de melanoma y otros canceres. |
| US9127293B2 (en) * | 2006-07-26 | 2015-09-08 | The University Of Chicago | Receptor-mediated delivery: compositions and methods |
| EP2208061B1 (en) * | 2007-09-26 | 2017-11-08 | Dana Farber Cancer Institute | Methods and compositions for modulating bcl-2 family polypeptides |
| CN101453818B (zh) | 2007-11-29 | 2014-03-19 | 杭州茂力半导体技术有限公司 | 放电灯的电路保护和调节装置 |
| JP2009258579A (ja) * | 2008-03-26 | 2009-11-05 | Fujifilm Corp | 平版印刷版原版の製版方法 |
| US8168755B2 (en) | 2008-05-07 | 2012-05-01 | Eutropics Pharmaceuticals, Inc. | Antibodies specific to heterodimers of Bcl-2 family and uses thereof |
| EP2393794B1 (en) | 2009-02-09 | 2017-03-22 | The Board of Trustees of the University of Illionis | Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs |
| WO2011095174A1 (en) * | 2010-02-08 | 2011-08-11 | Aarhus Universitet | Human herpes virus 6 and 7 u20 polypeptide and polynucleotides for use as a medicament or diagnosticum |
| CN108802385B (zh) | 2012-02-09 | 2022-02-08 | 米密德诊断学有限公司 | 用于诊断感染的标记和决定因素和其使用方法 |
| WO2013192423A2 (en) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| EP2922544B1 (en) | 2012-11-21 | 2018-08-01 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| US10732182B2 (en) | 2013-08-01 | 2020-08-04 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| EP3063302B1 (en) | 2013-10-30 | 2019-12-04 | Eutropics Pharmaceuticals, Inc. | Methods for determining chemosensitivity and chemotoxicity |
| CA3190715A1 (en) | 2014-08-14 | 2016-02-18 | Memed Diagnostics Ltd. | Computational analysis of biological data using manifold and a hyperplane |
| WO2016092554A1 (en) | 2014-12-11 | 2016-06-16 | Memed Diagnostics Ltd. | Marker combinations for diagnosing infections and methods of use thereof |
| HK1247250A1 (zh) | 2015-01-12 | 2018-09-21 | Eutropics Pharmaceuticals, Inc. | 用於指导癌症治疗的内容相关的诊断测试 |
| EP3423589B1 (en) * | 2016-03-03 | 2021-07-21 | Memed Diagnostics Ltd. | Analyzing rna for diagnosing infection type |
| US11466331B2 (en) | 2016-03-03 | 2022-10-11 | Memed Diagnostics Ltd. | RNA determinants for distinguishing between bacterial and viral infections |
| CN109661578B (zh) | 2016-07-10 | 2022-05-10 | 米密德诊断学有限公司 | 用于区分细菌和病毒感染的蛋白质特征 |
| WO2018011796A1 (en) | 2016-07-10 | 2018-01-18 | Memed Diagnostics Ltd. | Early diagnosis of infections |
| EP3519834A4 (en) | 2016-09-29 | 2020-06-17 | MeMed Diagnostics Ltd. | RISK ASSESSMENT AND DISEASE CLASSIFICATION METHODS |
| EP3519833B1 (en) | 2016-09-29 | 2024-08-14 | MeMed Diagnostics Ltd. | Methods of prognosis and treatment |
| EP4077416A4 (en) * | 2019-12-18 | 2023-11-22 | Standard Biotools Canada Inc. | MASS CYTOMETRY REAGENTS AND SIGNAL AMPLIFICATION METHODS |
| CN111939243B (zh) * | 2020-07-24 | 2021-04-13 | 武汉珈创生物技术股份有限公司 | Z-vad-fmk在制备人类1型单纯疱疹病毒抑制剂中的应用 |
| US20240027453A1 (en) * | 2020-07-28 | 2024-01-25 | The Trustees Of Princeton University | Method for detection and quantitative monitoring of infections with herpesviruses |
| CN111944746B (zh) * | 2020-08-04 | 2022-05-06 | 山东中医药大学 | 一种热刺激诱导细胞凋亡的方法 |
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| US5827702A (en) * | 1994-10-31 | 1998-10-27 | Genentech, Inc. | Ocular gene therapy |
| US5563039A (en) * | 1995-03-31 | 1996-10-08 | Tularik, Inc. | TNF receptor-associated intracellular signaling proteins and methods of use |
| US5656725A (en) * | 1995-05-12 | 1997-08-12 | Apoptosis Technology, Inc. | Peptides and compositions which modulate apoptosis |
| WO1997012632A1 (en) * | 1995-10-05 | 1997-04-10 | Tkb Associates Limited Partnership | Methods for treatment of diseases associated with a deficiency of fas ligand activity |
| JPH09124509A (ja) * | 1995-10-27 | 1997-05-13 | Sumitomo Electric Ind Ltd | 肝炎治療剤 |
| US5876923A (en) | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
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- 1999-05-06 CA CA002329868A patent/CA2329868A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112816637A (zh) * | 2020-06-17 | 2021-05-18 | 湖南慧泽生物医药科技有限公司 | 一种吗替麦考酚酯片的体外溶出方法 |
Also Published As
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| WO1999060171A1 (en) | 1999-11-25 |
| US20030198949A1 (en) | 2003-10-23 |
| US6902885B2 (en) | 2005-06-07 |
| US7449450B2 (en) | 2008-11-11 |
| EP1080233A4 (en) | 2003-02-05 |
| US6605426B1 (en) | 2003-08-12 |
| US20030207262A1 (en) | 2003-11-06 |
| JP2002515267A (ja) | 2002-05-28 |
| US20050191696A1 (en) | 2005-09-01 |
| EP1080233A1 (en) | 2001-03-07 |
| NZ507426A (en) | 2003-08-29 |
| AU762756B2 (en) | 2003-07-03 |
| AU3964399A (en) | 1999-12-06 |
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| EEER | Examination request | ||
| FZDE | Dead |