CA2326952A1 - Tyrosine-phosphatase de proteines de cellules t - Google Patents

Tyrosine-phosphatase de proteines de cellules t Download PDF

Info

Publication number
CA2326952A1
CA2326952A1 CA002326952A CA2326952A CA2326952A1 CA 2326952 A1 CA2326952 A1 CA 2326952A1 CA 002326952 A CA002326952 A CA 002326952A CA 2326952 A CA2326952 A CA 2326952A CA 2326952 A1 CA2326952 A1 CA 2326952A1
Authority
CA
Canada
Prior art keywords
tcptp
cell
cells
protein
jak
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002326952A
Other languages
English (en)
Inventor
C. Jane Mcglade
Paul Daniel Simoncic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospital for Sick Children HSC
Original Assignee
Hospital for Sick Children HSC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospital for Sick Children HSC filed Critical Hospital for Sick Children HSC
Priority to CA002326952A priority Critical patent/CA2326952A1/fr
Priority to PCT/CA2001/001679 priority patent/WO2002042489A1/fr
Priority to AU2002220412A priority patent/AU2002220412A1/en
Publication of CA2326952A1 publication Critical patent/CA2326952A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002326952A 2000-11-27 2000-11-27 Tyrosine-phosphatase de proteines de cellules t Abandoned CA2326952A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002326952A CA2326952A1 (fr) 2000-11-27 2000-11-27 Tyrosine-phosphatase de proteines de cellules t
PCT/CA2001/001679 WO2002042489A1 (fr) 2000-11-27 2001-11-27 Methodes faisant intervenir la proteine tyrosine phosphatase de lymphocyte t
AU2002220412A AU2002220412A1 (en) 2000-11-27 2001-11-27 Methods involving a t cell protein tyrosine phosphatase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002326952A CA2326952A1 (fr) 2000-11-27 2000-11-27 Tyrosine-phosphatase de proteines de cellules t

Publications (1)

Publication Number Publication Date
CA2326952A1 true CA2326952A1 (fr) 2002-05-27

Family

ID=4167752

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002326952A Abandoned CA2326952A1 (fr) 2000-11-27 2000-11-27 Tyrosine-phosphatase de proteines de cellules t

Country Status (3)

Country Link
AU (1) AU2002220412A1 (fr)
CA (1) CA2326952A1 (fr)
WO (1) WO2002042489A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0317099A (pt) 2002-12-09 2005-10-25 Boardd Of Regents Of The Unive Método in vitro para inibir a função e/ou proliferação de uma janus tirosina quinase 3, método de teste in vitro para auxiliar na identificação de substâncias que são úteis como imunossupressores terapêuticos, método in vitro para auxiliar na identificação de um novo medicamento imunossupressor, método in vitro para inibir a função e/ou proliferação de uma célula expressando a janus tirosina quinase 3, uso de pelo menos um composto, composto quìmico isolado ou purificado e composição farmacêutica
WO2008060540A2 (fr) * 2006-11-13 2008-05-22 President And Fellows Of Harvard College Procédés d'identification de compositions qui modulent la protéine tyrosine kinase, ptp-bl
WO2011094806A1 (fr) * 2010-02-03 2011-08-11 Monash University Dosage de diagnostic et de pronostic pour le cancer du sein
CA3070146A1 (fr) * 2016-07-19 2018-01-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Virus oncolytiques ciblant stat3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080772A (en) * 1995-06-07 2000-06-27 Sugen, Inc. Thiazole compounds and methods of modulating signal transduction
WO1999023493A1 (fr) * 1997-10-31 1999-05-14 The Rockefeller University Procedes d'identification d'agents modulant une activite de la leptine
CA2220853A1 (fr) * 1998-01-16 1999-07-16 Hsc Research And Development Limited Partnership Tyrosine phosphatase pour tissus lymphoides humains
AU1543600A (en) * 1998-12-11 2000-07-03 Mcgill University Therapeutic and diagnostic uses of protein tyrosine phosphatase tc-ptp
JP2003501098A (ja) * 1999-06-03 2003-01-14 コールド スプリング ハーバー ラボラトリー 基質捕捉性プロテインチロシンホスファターゼ
EP1214060A2 (fr) * 1999-09-10 2002-06-19 Novo Nordisk A/S Procede d'inhibition de la proteine tyrosine phosphatase 1b et/ou de la proteine tyrosine phosphatase de lymphocytes et/ou d'autres ptpases possedant un reste aps en position 48

Also Published As

Publication number Publication date
AU2002220412A1 (en) 2002-06-03
WO2002042489A1 (fr) 2002-05-30
WO2002042489A9 (fr) 2002-10-31

Similar Documents

Publication Publication Date Title
Ma et al. Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation
McPhee et al. Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family
Vitari et al. WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate
Woodford-Thomas et al. Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts
O'CONNELL et al. The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)
Karakashian et al. Expression of neutral sphingomyelinase‐2 (NSMase‐2) in primary rat hepatocytes modulates IL‐β‐induced JNK activation
He et al. ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes
Schneider et al. Migration of renal tumor cells depends on dephosphorylation of Shc by PTEN
Weng et al. Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas
US5831009A (en) Protein phosphotyrosine phosphatases PTP-D1
US20020048782A1 (en) Pyk2 related products and methods
Boratkó et al. RACK1 is involved in endothelial barrier regulation via its two novel interacting partners
AU2011214254B2 (en) Dual activity kinase domains and uses thereof
US6383734B1 (en) Method to determine inhibition of PAK3 activation of Raf-1
US5972674A (en) Stimulus-inducible protein kinase complex and methods of use therefor
KR20080023729A (ko) 미토겐-활성화 단백질 키나아제의 신규 인산화 자리, 변형단백질 및 적용
US6514719B1 (en) Methods for identifying compounds that alter kinase activity
CA2270911A1 (fr) Materiels de proteine-kinase point de controle du cycle cellulaire, effecteur de chk1 mammalien et methodes
CA2326952A1 (fr) Tyrosine-phosphatase de proteines de cellules t
AU2004296643B2 (en) Use of enzymatic inhibitors of h-PRUNE for the prevention and treatment of the metastases of tumours overexpressing h-PRUNE
US6511825B1 (en) Cell signaling polypeptides and nucleic acids
US20090181003A1 (en) Regulation of S6 Kinsase Protein Activity and Related Methods
US8278263B2 (en) Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor
US7037677B2 (en) Megakaryocytic protein tyrosine kinase I
Sephton SHP-1 and PDK1 Form a Phosphotyrosine-Dependent Nucleo-Cytoplasmic Shuttling Complex: Implications for Differentiation

Legal Events

Date Code Title Description
FZDE Dead