CA2324624A1 - Proteines de fixation de metastatine et d'hyaluronate et procedes d'utilisation - Google Patents

Proteines de fixation de metastatine et d'hyaluronate et procedes d'utilisation Download PDF

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Publication number
CA2324624A1
CA2324624A1 CA002324624A CA2324624A CA2324624A1 CA 2324624 A1 CA2324624 A1 CA 2324624A1 CA 002324624 A CA002324624 A CA 002324624A CA 2324624 A CA2324624 A CA 2324624A CA 2324624 A1 CA2324624 A1 CA 2324624A1
Authority
CA
Canada
Prior art keywords
protein
binding
amino acid
acid sequence
metastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002324624A
Other languages
English (en)
Inventor
Shawn J. Green
Charles B. Underhill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Casi Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2324624A1 publication Critical patent/CA2324624A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention concerne des compositions renfermant des peptides et des protéines de fixation d'hyaluronate (HA) ainsi que leurs procédés d'utilisations dans l'inhibition du cancer et des maladies liées à l'angiogenèse. Dans un mode préféré de réalisation, le module de liaison fixant l'acide hyaluronique est une protéine métastatine d'environ 38 kDA, inhibant la croissance tumorale et les métastases tumorales.
CA002324624A 1998-03-13 1999-03-12 Proteines de fixation de metastatine et d'hyaluronate et procedes d'utilisation Abandoned CA2324624A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7789898P 1998-03-13 1998-03-13
US60/077,898 1998-03-13
US10812498P 1998-11-12 1998-11-12
US60/108,124 1998-11-12
PCT/US1999/005498 WO1999045942A1 (fr) 1998-03-13 1999-03-12 Proteines de fixation de metastatine et d'hyaluronate et procedes d'utilisation

Publications (1)

Publication Number Publication Date
CA2324624A1 true CA2324624A1 (fr) 1999-09-16

Family

ID=26759825

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002324624A Abandoned CA2324624A1 (fr) 1998-03-13 1999-03-12 Proteines de fixation de metastatine et d'hyaluronate et procedes d'utilisation

Country Status (4)

Country Link
EP (1) EP1064011A1 (fr)
AU (1) AU3085699A (fr)
CA (1) CA2324624A1 (fr)
WO (1) WO1999045942A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6358735B1 (en) 1995-06-30 2002-03-19 University Of Kansas Medical Center Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen
US6440729B1 (en) 1995-06-30 2002-08-27 University Of Kansas Medical Center Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen
KR20020065510A (ko) * 1999-12-17 2002-08-13 다케다 야쿠힌 고교 가부시키가이샤 ＫｉＳＳ-1 펩티드의 제조 방법
SE0003260D0 (sv) * 2000-09-14 2000-09-14 Anders Uhlin New use of hyaluronan
AU2002326277B2 (en) * 2001-08-24 2007-10-04 Celecure As New drug
AUPR856501A0 (en) * 2001-10-30 2001-11-29 Peter Maccallum Cancer Institute, The Detection of haematopoietic stem cells and progeny and uses thereof
WO2008100789A2 (fr) 2007-02-16 2008-08-21 Benaroya Research Institute At Virginia Mason Compositions et procédés pour modifier l'élastogenèse
US20100249064A1 (en) * 2007-09-07 2010-09-30 University Of Chicago Methods and compositions for treating diseases and conditions involving higher molecular weight hyaluronan
WO2013025936A1 (fr) * 2011-08-18 2013-02-21 Cornell University Détection et traitement d'une maladie métastatique
US8846034B2 (en) 2011-10-24 2014-09-30 Halozyme, Inc. Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
WO2015021993A1 (fr) 2013-08-13 2015-02-19 Ibcc Holding As Molécules sb101 modifiées pharmacologiquement actives et leurs utilisations
US9572832B2 (en) 2013-08-29 2017-02-21 Holy Stone Healthcare Co., Ltd. Compound of glycosaminoglycan and its fabrication method as well as application
CN104988561A (zh) * 2015-07-20 2015-10-21 江南大学 一种基于透明质酸复合胶束的生物涂层制备方法
WO2020072640A1 (fr) * 2018-10-02 2020-04-09 The Wistar Institute Of Anatomy And Biology Compositions et procédés de prévention et de réduction de métastase

Also Published As

Publication number Publication date
EP1064011A1 (fr) 2001-01-03
AU3085699A (en) 1999-09-27
WO1999045942A1 (fr) 1999-09-16

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Legal Events

Date Code Title Description
FZDE Discontinued