CA2319057C - Compositions comprising a poly(oxyethylene)-poly(oxypropylene) block copolymer and their use - Google Patents
Compositions comprising a poly(oxyethylene)-poly(oxypropylene) block copolymer and their use Download PDFInfo
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- CA2319057C CA2319057C CA2319057A CA2319057A CA2319057C CA 2319057 C CA2319057 C CA 2319057C CA 2319057 A CA2319057 A CA 2319057A CA 2319057 A CA2319057 A CA 2319057A CA 2319057 C CA2319057 C CA 2319057C
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- block copolymer
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- biologically active
- ethylene oxide
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- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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- A61K38/20—Interleukins [IL]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/019,648 US6277410B1 (en) | 1992-10-08 | 1998-02-06 | Copolymer compositions for oral delivery |
| US09/019,648 | 1998-02-06 | ||
| PCT/US1999/002538 WO1999039731A1 (en) | 1998-02-06 | 1999-02-05 | Copolymer compositions for oral delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2319057A1 CA2319057A1 (en) | 1999-08-12 |
| CA2319057C true CA2319057C (en) | 2010-05-04 |
Family
ID=21794304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2319057A Expired - Fee Related CA2319057C (en) | 1998-02-06 | 1999-02-05 | Compositions comprising a poly(oxyethylene)-poly(oxypropylene) block copolymer and their use |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6277410B1 (enExample) |
| EP (1) | EP1053010B1 (enExample) |
| JP (1) | JP4685237B2 (enExample) |
| AT (1) | ATE426397T1 (enExample) |
| AU (1) | AU2496199A (enExample) |
| CA (1) | CA2319057C (enExample) |
| DE (1) | DE69940635D1 (enExample) |
| WO (1) | WO1999039731A1 (enExample) |
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| US6153193A (en) * | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
| US6277410B1 (en) * | 1992-10-08 | 2001-08-21 | Supratek Pharma Inc. | Copolymer compositions for oral delivery |
| US6093391A (en) * | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
| US6353055B1 (en) | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
| IL141438A0 (en) * | 2000-02-23 | 2002-03-10 | Pfizer Prod Inc | Method of increasing the bioavailability and tissue penetration of azithromycin |
| EP1563850A3 (en) * | 2000-02-23 | 2008-02-20 | Pfizer Products Inc. | Method of increasing the bioavailability and tissue penetration of azithromycin |
| WO2001083698A2 (en) * | 2000-04-28 | 2001-11-08 | Supratek Pharma, Inc. | Compositions and methods for inducing activation of dendritic cells |
| US7256180B2 (en) | 2000-04-28 | 2007-08-14 | Supratek Pharma Inc. | Compositions and methods for inducing activation of dendritic cells |
| EP1289542B1 (en) * | 2000-05-26 | 2008-07-16 | Frohwitter, Bernhard | Means for maintenance and/or correction of glucose concentration in blood |
| AU2002254342A1 (en) * | 2001-03-23 | 2002-10-08 | The Board Of Trustees Of The University Of Illinois | Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same |
| GB0131112D0 (en) * | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
| US20040220283A1 (en) * | 2002-07-29 | 2004-11-04 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| AU2003261274C1 (en) * | 2002-07-29 | 2009-02-12 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
| US7550155B2 (en) * | 2002-07-29 | 2009-06-23 | Transform Pharmaceuticals Inc. | Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses |
| DK1551876T3 (da) | 2002-10-16 | 2011-06-14 | Purdue Pharma Lp | Antistoffer, der binder til celle-associerede ca 125/0722P og fremgangsmåder til anvendelse deraf |
| US7422875B2 (en) | 2004-07-20 | 2008-09-09 | Board Of Regents Of The University Of Nebraska | Compositions and methods for increasing protein production |
| US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
| US8168222B2 (en) | 2004-09-07 | 2012-05-01 | Board Of Regents Of The University Of Nebraska | Amphiphilic polymer-protein conjugates and methods of use thereof |
| WO2006099175A2 (en) * | 2005-03-11 | 2006-09-21 | Euro-Celtique S.A. | Compositions comprising an anti-ca125 antibody and a cytotoxic compound and their use for the treatment of cancer |
| TW200735770A (en) * | 2006-01-10 | 2007-10-01 | Innovaform Technologies Llc | Pesticide delivery system |
| US8148338B2 (en) * | 2006-02-22 | 2012-04-03 | Supratek Pharma Inc. | Doxorubicin formulations for anti-cancer use |
| RU2409363C9 (ru) | 2009-09-18 | 2013-12-10 | Всеволод Иванович Киселев | Фармацевтические композиции для пероральной доставки дииндолилметана (dim) и способы применения этих композиций |
| US8946301B2 (en) | 2011-11-29 | 2015-02-03 | Als Therapy Development Institute | Targeting of T-lymphocytes to treat amyotrophic lateral sclerosis |
| US8912215B2 (en) * | 2011-12-13 | 2014-12-16 | Everon Biosciences, Inc. | Rapamycin composition |
| US20240024354A1 (en) * | 2020-09-04 | 2024-01-25 | The University Of Chicago | Materials and methods of treating viral infection with amphiphilic block copolymers |
| EP4522183A2 (en) | 2022-05-11 | 2025-03-19 | Celgene Corporation | Methods and uses related to t cell therapy and production of same |
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| US4027013A (en) | 1976-01-22 | 1977-05-31 | William L. Wilson | Clottable fibrinogen free factor VIII and albumin product and process |
| US4188373A (en) | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| US4106474A (en) | 1977-03-17 | 1978-08-15 | Modine Manufacturing Company | Heat conserving space heater |
| US4865835A (en) | 1982-06-02 | 1989-09-12 | Begent Richard H J | Diagnosis and treatment of tumors |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| US4474752A (en) | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| ES8601706A1 (es) * | 1983-05-16 | 1985-11-16 | Merck & Co Inc | Una composicion farmaceutica |
| US4485457A (en) | 1983-05-31 | 1984-11-27 | Cbs Inc. | Memory system including RAM and page switchable ROM |
| US4772466A (en) | 1983-08-22 | 1988-09-20 | Syntex (U.S.A.) Inc. | Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US4957735A (en) | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| JPS61103836A (ja) | 1984-10-24 | 1986-05-22 | Green Cross Corp:The | フイブロネクチン製剤 |
| AU596986B2 (en) * | 1985-06-18 | 1990-05-24 | Emory University | Biologically-active copolymers |
| US5114708A (en) | 1985-06-18 | 1992-05-19 | Emory University | Method for stimulating growth in animals |
| US5494660A (en) | 1985-06-18 | 1996-02-27 | Emory University | Method for inhibiting microbial binding to surfaces |
| US5466445A (en) | 1985-06-18 | 1995-11-14 | Emory University | Methods for reducing salmonella in chickens |
| US5183687A (en) | 1985-06-18 | 1993-02-02 | Emory University | Method of treating poultry for coccidiosis |
| US5234683A (en) | 1985-06-18 | 1993-08-10 | Emory University | Method of stimulating the immune system |
| JPS6270319A (ja) * | 1985-07-30 | 1987-03-31 | インタ−ナシヨナル・ミネラルズ・アンド・ケミカル・コ−ポレイシヨン | 成長促進ホルモンの安定化 |
| US5071649A (en) | 1986-05-15 | 1991-12-10 | Emory University | Method of preventing blockage in catheters |
| US5032394A (en) | 1986-05-15 | 1991-07-16 | Emory University | Method of treating burns |
| US5182106A (en) | 1986-05-15 | 1993-01-26 | Emory University | Method for treating hypothermia |
| US5240702A (en) | 1986-05-15 | 1993-08-31 | Emory University | Method of treating stroke |
| US5041288A (en) | 1986-05-15 | 1991-08-20 | Emory University | Method of treating tissue damaged by reperfusion injury |
| US5039520A (en) | 1986-05-15 | 1991-08-13 | Emory University | Plasma extender |
| US4937070A (en) | 1986-05-15 | 1990-06-26 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
| US4873083A (en) | 1986-05-15 | 1989-10-10 | Emory University | Fibrinolytic composition |
| US4997644A (en) | 1986-05-15 | 1991-03-05 | Emory University | Method of treating adult respiratory distress syndrome |
| US5250294A (en) | 1986-05-15 | 1993-10-05 | Emory University | Improved perfusion medium for transplantation of organs |
| US5028599A (en) | 1986-05-15 | 1991-07-02 | Emory University | Method of treating mycardial damage |
| US4897263A (en) | 1986-05-15 | 1990-01-30 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
| US5080894A (en) | 1986-05-15 | 1992-01-14 | Emory University | Method and composition for reducing tissue damage |
| US4837014A (en) | 1986-05-15 | 1989-06-06 | Emory University | An improved method of treating sickle cell anemia |
| US5089260A (en) | 1986-05-15 | 1992-02-18 | Emory University | Method of treating ischemic tissue |
| US5030448A (en) | 1986-05-15 | 1991-07-09 | Emory University | Method of delivering drugs to damaged or diseased tissue |
| US5240701A (en) | 1986-05-15 | 1993-08-31 | Emory University | Method of performing angioplasty procedures |
| US4801452A (en) | 1986-05-15 | 1989-01-31 | Hunter Robert L | Fibrinolytic composition |
| US4879109A (en) | 1986-05-15 | 1989-11-07 | Emory University | Method for treating burns |
| US5648071A (en) * | 1986-05-15 | 1997-07-15 | Emory University | Method of treating tumors |
| US5064643A (en) | 1986-05-15 | 1991-11-12 | Emory University | Method for treating sickle cell disease |
| US5078995A (en) | 1986-05-15 | 1992-01-07 | Emory University | Fibrionolytic composition |
| US5198211A (en) | 1986-05-15 | 1993-03-30 | Emory University | Method of treating myocardial damage |
| US5017370A (en) | 1986-05-15 | 1991-05-21 | Emory University | Improved method of performing angioplasty procedures |
| US5152979A (en) | 1986-05-15 | 1992-10-06 | Emory University | Method for treating vascular obstructions caused by abnormal cells |
| US5047236A (en) | 1986-05-15 | 1991-09-10 | Emory University | Method of treating stroke |
| US4882168A (en) | 1986-09-05 | 1989-11-21 | American Cyanamid Company | Polyesters containing alkylene oxide blocks as drug delivery systems |
| US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
| DE3750176T2 (de) * | 1986-09-22 | 1994-10-13 | Emory University, Atlanta, Ga. | Impfstoff und verfahren zur herstellung. |
| US5567859A (en) * | 1991-03-19 | 1996-10-22 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| AU1396588A (en) * | 1987-02-20 | 1988-09-14 | Emory University | Antiinfective compounds and method of use |
| US5674911A (en) * | 1987-02-20 | 1997-10-07 | Cytrx Corporation | Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use |
| CA1335879C (en) | 1987-07-27 | 1995-06-13 | Bruce Andrew Cornell | Receptor membranes |
| US4853228A (en) | 1987-07-28 | 1989-08-01 | Micro-Pak, Inc. | Method of manufacturing unilamellar lipid vesicles |
| IE911403A1 (en) * | 1990-04-26 | 1991-11-06 | Cytrx Corp | Compositions and method for topical treatment of damaged or¹diseased tissue |
| NZ238731A (en) * | 1990-06-27 | 1996-02-27 | Univ Emory | Vaccine adjuvant compositions comprising ethyleneoxy-propyleneoxy-ethyleneoxy block copolymer or a non-toxic lipopolysaccharide |
| US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| DE69230372T2 (de) * | 1991-03-19 | 2000-06-15 | Cytrx Corp., Norcross | Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5622649A (en) | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
| CA2120359C (en) | 1991-10-04 | 2000-12-26 | Tomas Landh | Particles, method of preparing said particles and uses thereof |
| US5681812A (en) * | 1991-12-10 | 1997-10-28 | Rush Presbyterian-St. Luke's Medical Center | Methods and compositions for reducing multidrug resistance |
| US5470568A (en) | 1992-02-13 | 1995-11-28 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for cell repair |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
| US5840319A (en) | 1992-10-08 | 1998-11-24 | Alakhov; Valery Yu | Biological agent compositions |
| US6277410B1 (en) | 1992-10-08 | 2001-08-21 | Supratek Pharma Inc. | Copolymer compositions for oral delivery |
| ATE198268T1 (de) | 1992-10-08 | 2001-01-15 | Supratek Pharma Inc | Zusammensetzung von in mizellen eingeschlossenen antineoplastischen wirkstoffen |
| US6153193A (en) | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
| US5488034A (en) | 1993-02-02 | 1996-01-30 | Xoma Corporation | Pharmaceutical composition comprising BPI proteins |
| IL106578A (en) | 1993-08-03 | 2000-08-13 | Yissum Res Dev Co | Pharmaceutical compositions for drug targeting |
| US5417982A (en) | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| US5401296A (en) | 1994-06-28 | 1995-03-28 | Martenson; Irvin | Precious metal extraction process |
| US5656611A (en) | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
| US6040295A (en) | 1995-01-13 | 2000-03-21 | Genemedicine, Inc. | Formulated nucleic acid compositions and methods of administering the same for gene therapy |
| AUPN801296A0 (en) * | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
| JP4117922B2 (ja) * | 1996-03-28 | 2008-07-16 | 武田薬品工業株式会社 | 徐放性製剤およびその製造法 |
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1998
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- 1999-02-05 AU AU24961/99A patent/AU2496199A/en not_active Abandoned
- 1999-02-05 EP EP99904594A patent/EP1053010B1/en not_active Expired - Lifetime
- 1999-02-05 AT AT99904594T patent/ATE426397T1/de not_active IP Right Cessation
- 1999-02-05 DE DE69940635T patent/DE69940635D1/de not_active Expired - Lifetime
- 1999-02-05 WO PCT/US1999/002538 patent/WO1999039731A1/en not_active Ceased
- 1999-02-05 CA CA2319057A patent/CA2319057C/en not_active Expired - Fee Related
-
2001
- 2001-07-17 US US09/907,397 patent/US6387406B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69940635D1 (de) | 2009-05-07 |
| WO1999039731A1 (en) | 1999-08-12 |
| AU2496199A (en) | 1999-08-23 |
| ATE426397T1 (de) | 2009-04-15 |
| US6277410B1 (en) | 2001-08-21 |
| EP1053010A1 (en) | 2000-11-22 |
| EP1053010A4 (en) | 2002-08-21 |
| CA2319057A1 (en) | 1999-08-12 |
| US6387406B1 (en) | 2002-05-14 |
| JP4685237B2 (ja) | 2011-05-18 |
| JP2002502825A (ja) | 2002-01-29 |
| EP1053010B1 (en) | 2009-03-25 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150205 |