CA2319038A1 - Peptides analgesiques extraits du venin de la grammostola spatulata et leur utilisation - Google Patents

Peptides analgesiques extraits du venin de la grammostola spatulata et leur utilisation Download PDF

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Publication number
CA2319038A1
CA2319038A1 CA002319038A CA2319038A CA2319038A1 CA 2319038 A1 CA2319038 A1 CA 2319038A1 CA 002319038 A CA002319038 A CA 002319038A CA 2319038 A CA2319038 A CA 2319038A CA 2319038 A1 CA2319038 A1 CA 2319038A1
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CA
Canada
Prior art keywords
cys
lys
trp
glu
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002319038A
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English (en)
Inventor
Richard Alexander Lampe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2319038A1 publication Critical patent/CA2319038A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention porte sur de nouvelles méthodes de traitement de la douleur consistant à administrer à un mammifère le nécessitant une dose à effet analgésique d'un peptide présentant soit la séquence d'acides aminés: Tyr-Cys-Gln-Lys-Trp-Leu-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Arg-Leu-NH2 (SEQ ID NO:1), soit la séquence d'acides aminés: Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Glu-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Leu-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Ile-Glu-Trp (SEQ ID NO:2. L'invention porte également sur un peptide purifié présentant la séquence d'acides aminés SEQ ID NO:1. Les peptides des séquences SEQ ID NO:1 et SEQ ID NO:2 peuvent de plus être utilisés dans des méthodes d'identification de composés analgésiogènes.
CA002319038A 1998-02-20 1998-02-20 Peptides analgesiques extraits du venin de la grammostola spatulata et leur utilisation Abandoned CA2319038A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB1998/000534 WO1999042480A1 (fr) 1998-02-20 1998-02-20 Peptides analgesiques extraits du venin de la grammostola spatulata et leur utilisation

Publications (1)

Publication Number Publication Date
CA2319038A1 true CA2319038A1 (fr) 1999-08-26

Family

ID=10825125

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002319038A Abandoned CA2319038A1 (fr) 1998-02-20 1998-02-20 Peptides analgesiques extraits du venin de la grammostola spatulata et leur utilisation

Country Status (5)

Country Link
EP (1) EP1054896A1 (fr)
JP (1) JP2002509080A (fr)
AU (1) AU6109698A (fr)
CA (1) CA2319038A1 (fr)
WO (1) WO1999042480A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4742345B2 (ja) * 2006-06-20 2011-08-10 独立行政法人産業技術総合研究所 カルシウムチャネルを遮断するグラモストラ・スパチュラタ由来のポリペプチドおよびその遺伝子
FR2940973B1 (fr) * 2009-01-15 2013-05-24 Centre Nat Rech Scient Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique
AU2012300197B2 (en) * 2011-08-24 2018-01-18 The University Of Queensland Pest-controlling agents isolated from spider venom and uses thereof
WO2023215528A1 (fr) * 2022-05-04 2023-11-09 University Of Rochester Utilisation de gsmtx4 et de conjugués de gsmtx4 pour améliorer la guérison après une blessure articulaire

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
EP1336409B1 (fr) * 1995-06-27 2007-04-11 Eisai R&D Management Co., Ltd. Compositions et formulations permettant de produire une analgésie et d'inhiber la progression de troubles liés à des douleurs neuropathiques
US5756663A (en) * 1996-01-03 1998-05-26 Zeneca Limited Antiarrhythmic peptide from venom of spider Grammostola spatulata

Also Published As

Publication number Publication date
AU6109698A (en) 1999-09-06
WO1999042480A1 (fr) 1999-08-26
JP2002509080A (ja) 2002-03-26
EP1054896A1 (fr) 2000-11-29

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FZDE Dead