CA2318735A1 - Method and apparatus for non-invasive determination of glucose in body fluids - Google Patents
Method and apparatus for non-invasive determination of glucose in body fluids Download PDFInfo
- Publication number
- CA2318735A1 CA2318735A1 CA002318735A CA2318735A CA2318735A1 CA 2318735 A1 CA2318735 A1 CA 2318735A1 CA 002318735 A CA002318735 A CA 002318735A CA 2318735 A CA2318735 A CA 2318735A CA 2318735 A1 CA2318735 A1 CA 2318735A1
- Authority
- CA
- Canada
- Prior art keywords
- impedance
- glucose
- subject
- amount
- determining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 155
- 239000008103 glucose Substances 0.000 title claims abstract description 155
- 238000000034 method Methods 0.000 title claims abstract description 52
- 210000001124 body fluid Anatomy 0.000 title claims description 32
- 239000010839 body fluid Substances 0.000 title claims description 32
- 239000008280 blood Substances 0.000 claims abstract description 57
- 210000004369 blood Anatomy 0.000 claims abstract description 57
- 238000002847 impedance measurement Methods 0.000 claims abstract description 32
- 238000005259 measurement Methods 0.000 claims abstract description 31
- 210000003491 skin Anatomy 0.000 claims description 52
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 24
- 102000004877 Insulin Human genes 0.000 claims description 12
- 108090001061 Insulin Proteins 0.000 claims description 12
- 229940125396 insulin Drugs 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 11
- 230000004044 response Effects 0.000 claims description 11
- 210000000245 forearm Anatomy 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 9
- 230000000007 visual effect Effects 0.000 claims description 5
- 210000000434 stratum corneum Anatomy 0.000 claims description 4
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- 230000002596 correlated effect Effects 0.000 abstract description 3
- 239000012530 fluid Substances 0.000 abstract 2
- 239000000523 sample Substances 0.000 description 18
- 238000013459 approach Methods 0.000 description 6
- 230000002500 effect on skin Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000000707 wrist Anatomy 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 238000013528 artificial neural network Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 238000007446 glucose tolerance test Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000037067 skin hydration Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000001690 micro-dialysis Methods 0.000 description 1
- 231100000067 mild irritant Toxicity 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000004306 orthophenyl phenol Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0531—Measuring skin impedance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1998/002037 WO1999039627A1 (en) | 1998-02-04 | 1998-02-04 | Method and apparatus for non-invasive determination of glucose in body fluids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2318735A1 true CA2318735A1 (en) | 1999-08-12 |
Family
ID=22266324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002318735A Abandoned CA2318735A1 (en) | 1998-02-04 | 1998-02-04 | Method and apparatus for non-invasive determination of glucose in body fluids |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1052929A1 (enExample) |
| JP (1) | JP2002501802A (enExample) |
| AU (1) | AU762922B2 (enExample) |
| CA (1) | CA2318735A1 (enExample) |
| WO (1) | WO1999039627A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9017258B2 (en) | 2002-10-11 | 2015-04-28 | Scibase Ab | Determination of biological conditions using impedance measurements |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030031894A (ko) * | 2001-02-05 | 2003-04-23 | 글루코센스 인코퍼레이티드 | 혈중 포도당 농도의 측정 방법 |
| US7315767B2 (en) | 2001-03-06 | 2008-01-01 | Solianis Holding Ag | Impedance spectroscopy based systems and methods |
| CZ20032650A3 (cs) | 2001-03-06 | 2004-04-14 | Pendragon Medical Ltd. | Způsob a zařízení k určení koncentrace látky v tělní tekutině |
| US7050847B2 (en) | 2002-03-26 | 2006-05-23 | Stig Ollmar | Non-invasive in vivo determination of body fluid parameter |
| WO2004021877A1 (en) | 2002-09-04 | 2004-03-18 | Pendragon Medical Ltd. | Method and device for measuring glucose |
| AU2003264797A1 (en) * | 2002-09-05 | 2004-03-29 | Pendragon Medical Ltd. | Impedance spectroscopy based systems and methods |
| ATE419783T1 (de) | 2002-09-24 | 2009-01-15 | Solianis Holding Ag | Vorrichtung zur messung von glukosekonzentrationen |
| US7452457B2 (en) | 2003-06-20 | 2008-11-18 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using dose sufficiency electrodes |
| US7597793B2 (en) | 2003-06-20 | 2009-10-06 | Roche Operations Ltd. | System and method for analyte measurement employing maximum dosing time delay |
| US7604721B2 (en) | 2003-06-20 | 2009-10-20 | Roche Diagnostics Operations, Inc. | System and method for coding information on a biosensor test strip |
| ATE531309T1 (de) | 2003-12-02 | 2011-11-15 | Solianis Holding Ag | Vorrichtung und verfahren zur messung einer eigenschaft von lebendem gewebe |
| PL1718200T3 (pl) | 2004-02-05 | 2017-01-31 | Dermal Devices Inc. | Urządzenie do mierzenia glukozy we krwi z użyciem pomiarów impedancji sub-skórnej tkanki ciała |
| EP1718196B1 (en) | 2004-02-26 | 2009-04-08 | Diabetes Tools Sweden AB | Metabolic monitoring, a method and apparatus for indicating a health-related condition of a subject |
| SE0400456D0 (sv) * | 2004-02-26 | 2004-02-26 | Lars Liljeryd | Multiparameter metabolic monitoring, a method and device for the improvement of management and control in borderline or manifest type 2-diabetes |
| KR101118870B1 (ko) * | 2004-06-07 | 2012-03-19 | 솔리아니스 홀딩 아게 | 살아있는 조직의 파라미터를 결정하기 위한 장치 |
| US7556723B2 (en) | 2004-06-18 | 2009-07-07 | Roche Diagnostics Operations, Inc. | Electrode design for biosensor |
| US7569126B2 (en) | 2004-06-18 | 2009-08-04 | Roche Diagnostics Operations, Inc. | System and method for quality assurance of a biosensor test strip |
| DK1959828T3 (da) | 2005-12-14 | 2013-05-21 | Scibase Ab | Diagnosticering af en sygdomstilstand i huden ved brug af impedans |
| US9636035B2 (en) | 2005-12-14 | 2017-05-02 | Scibase Ab | Medical apparatus for determination of biological conditions using impedance measurements |
| WO2009086643A1 (en) * | 2008-01-11 | 2009-07-16 | Solianis Holding Ag | A method and device for determining a property of living tissue |
| EP2196140B1 (de) * | 2008-12-11 | 2014-03-19 | Trout GmbH | Verfahren und Einrichtung zur nicht invasiven Bestimmung des Blutzuckergehalts im Blut |
| RU2518134C2 (ru) * | 2012-02-24 | 2014-06-10 | Хилби Корпорейшн | Способ определения концентрации глюкозы в крови человека |
| CN106691449A (zh) | 2016-11-21 | 2017-05-24 | 清华大学 | 一种基于阻抗谱‑光学方法的多传感器无创血糖检测设备 |
| CN112336331B (zh) * | 2020-10-19 | 2023-11-17 | 桂林市晶瑞传感技术有限公司 | 一种局部人体成分数据处理方法及分析仪 |
| GB2604110B (en) * | 2021-02-22 | 2023-03-01 | Zelemiq Ltd | Methods and apparatus for transdermal measurement of impedance |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1934139A1 (de) * | 1969-07-05 | 1971-01-21 | Forster Dipl Ing Arnold | Geraet zur UEberwachung des Stoffwechsels im lebenden Zellgewebe |
| US5197951A (en) | 1983-12-14 | 1993-03-30 | Mahurkar Sakharam D | Simple double lumen catheter |
| JPS61259645A (ja) * | 1985-05-14 | 1986-11-17 | シチズン時計株式会社 | 低血糖検出装置 |
| US5036861A (en) | 1990-01-11 | 1991-08-06 | Sembrowich Walter L | Method and apparatus for non-invasively monitoring plasma glucose levels |
| US5222496A (en) | 1990-02-02 | 1993-06-29 | Angiomedics Ii, Inc. | Infrared glucose sensor |
| US5079421A (en) | 1990-04-19 | 1992-01-07 | Inomet, Inc. | Invasive FTIR blood constituent testing |
| US5115133A (en) | 1990-04-19 | 1992-05-19 | Inomet, Inc. | Testing of body fluid constituents through measuring light reflected from tympanic membrane |
| GB9204689D0 (en) * | 1992-03-04 | 1992-04-15 | Univ Wales | Analytical method & apparatus |
| CA2090699A1 (en) * | 1990-08-30 | 1992-03-01 | Douglas B. Kell | Analytical method |
| SE466987B (sv) | 1990-10-18 | 1992-05-11 | Stiftelsen Ct Foer Dentaltekni | Anordning foer djupselektiv icke-invasiv, lokal maetning av elektrisk impedans i organiska och biologiska material samt prob foer maetning av elektrisk impedans |
| US5433197A (en) | 1992-09-04 | 1995-07-18 | Stark; Edward W. | Non-invasive glucose measurement method and apparatus |
| US5792668A (en) | 1993-08-06 | 1998-08-11 | Solid State Farms, Inc. | Radio frequency spectral analysis for in-vitro or in-vivo environments |
| US5508203A (en) | 1993-08-06 | 1996-04-16 | Fuller; Milton E. | Apparatus and method for radio frequency spectroscopy using spectral analysis |
| EP0955871A4 (en) * | 1995-04-20 | 2000-03-22 | Microcor Inc | METHOD AND APPARATUS FOR NON-INVASIVE DETERMINATION OF HEMATOCRITIS |
| US5752512A (en) * | 1995-05-10 | 1998-05-19 | Massachusetts Institute Of Technology | Apparatus and method for non-invasive blood analyte measurement |
| US5890489A (en) * | 1996-04-23 | 1999-04-06 | Dermal Therapy (Barbados) Inc. | Method for non-invasive determination of glucose in body fluids |
-
1998
- 1998-02-04 CA CA002318735A patent/CA2318735A1/en not_active Abandoned
- 1998-02-04 EP EP98906104A patent/EP1052929A1/en not_active Withdrawn
- 1998-02-04 WO PCT/US1998/002037 patent/WO1999039627A1/en not_active Ceased
- 1998-02-04 JP JP2000530135A patent/JP2002501802A/ja active Pending
- 1998-02-04 AU AU61421/98A patent/AU762922B2/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9017258B2 (en) | 2002-10-11 | 2015-04-28 | Scibase Ab | Determination of biological conditions using impedance measurements |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1052929A1 (en) | 2000-11-22 |
| AU762922B2 (en) | 2003-07-10 |
| WO1999039627A1 (en) | 1999-08-12 |
| JP2002501802A (ja) | 2002-01-22 |
| AU6142198A (en) | 1999-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |