CA2318639A1 - Antagonistes d'antigene-4 d'activation tres tardive (vla-4) - Google Patents

Antagonistes d'antigene-4 d'activation tres tardive (vla-4) Download PDF

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Publication number
CA2318639A1
CA2318639A1 CA002318639A CA2318639A CA2318639A1 CA 2318639 A1 CA2318639 A1 CA 2318639A1 CA 002318639 A CA002318639 A CA 002318639A CA 2318639 A CA2318639 A CA 2318639A CA 2318639 A1 CA2318639 A1 CA 2318639A1
Authority
CA
Canada
Prior art keywords
substituted
alkyl
aryl
alkenyl
substituted alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002318639A
Other languages
English (en)
Inventor
Peter Josef Von Matt
Sompong Wattanasin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2318639A1 publication Critical patent/CA2318639A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Les composés correspondant à la formule (I) ainsi que leurs sels acceptables du point de vue pharmaceutique sont des antagonistes du VLA-4. Ils inhibent efficacement l'adhésion cellulaires et se révèlent comme des plus utiles en matière de traitement ou de prophylaxie de maladies inflammatoires ou auto-immunes, notamment des maladies inflammatoires des voies respiratoires. Ils s'avèrent particulièrement efficaces s'agissant d'atténuer une inflammation post-chirurgicale, résultant notamment d'une greffe.
CA002318639A 1998-01-23 1999-01-21 Antagonistes d'antigene-4 d'activation tres tardive (vla-4) Abandoned CA2318639A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1233698A 1998-01-23 1998-01-23
US09/012,336 1998-01-23
US11072398P 1998-12-03 1998-12-03
US60/110,723 1998-12-03
PCT/EP1999/000384 WO1999037605A1 (fr) 1998-01-23 1999-01-21 Antagonistes d'antigene-4 d'activation tres tardive (vla-4)

Publications (1)

Publication Number Publication Date
CA2318639A1 true CA2318639A1 (fr) 1999-07-29

Family

ID=26683440

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318639A Abandoned CA2318639A1 (fr) 1998-01-23 1999-01-21 Antagonistes d'antigene-4 d'activation tres tardive (vla-4)

Country Status (13)

Country Link
EP (1) EP1049665A1 (fr)
JP (1) JP4564654B2 (fr)
KR (1) KR20010034317A (fr)
CN (1) CN1294576A (fr)
AU (1) AU746174B2 (fr)
BR (1) BR9907733A (fr)
CA (1) CA2318639A1 (fr)
EE (1) EE200000428A (fr)
HU (1) HUP0100336A3 (fr)
ID (1) ID26665A (fr)
IL (1) IL137329A0 (fr)
NO (1) NO20003694L (fr)
WO (1) WO1999037605A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043369A1 (fr) * 1999-01-22 2000-07-27 Elan Pharmaceuticals, Inc. Composes inhibant l'adhesion aux leucocytes a mediation assuree par vla-4
IL143929A0 (en) 1999-01-22 2002-04-21 Elan Pharm Inc Acyl derivatives which treat vla-4 related disorders
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
AU3246600A (en) 1999-03-01 2000-09-21 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 receptor antagonists
AU3006401A (en) * 1999-12-07 2001-06-18 Novartis Ag Vla-4 integrin antagonists
JP2003519697A (ja) 1999-12-28 2003-06-24 ファイザー・プロダクツ・インク 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のｖｌａ−４依存性細胞結合阻害薬
DE10019755A1 (de) * 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
GB2369357A (en) * 2000-10-09 2002-05-29 Bayer Ag Aliphatic, cyclic amino carboxylic acids as integrin antagonists
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
GB0523576D0 (en) * 2005-11-18 2005-12-28 Theradeas Ltd Drug composition and its use in therapy
EP2510941A3 (fr) 2007-02-20 2013-01-23 Merrimack Pharmaceuticals, Inc. Procédés de traitement de la sclérose en plaques par administration d'une alpha-foetoprotéine combinée à un antagoniste de l'intégrine
EP2860260A1 (fr) 2008-04-11 2015-04-15 Merrimack Pharmaceuticals, Inc. Lieurs d'albumine de sérum humain et de leurs conjugués

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
ATE289991T1 (de) * 1997-12-23 2005-03-15 Aventis Pharma Ltd Substituierte beta-alaninen

Also Published As

Publication number Publication date
ID26665A (id) 2001-01-25
JP4564654B2 (ja) 2010-10-20
CN1294576A (zh) 2001-05-09
AU2829299A (en) 1999-08-09
HUP0100336A2 (hu) 2001-07-30
AU746174B2 (en) 2002-04-18
NO20003694L (no) 2000-09-20
BR9907733A (pt) 2000-10-17
JP2002501039A (ja) 2002-01-15
HUP0100336A3 (en) 2002-11-28
IL137329A0 (en) 2001-07-24
EP1049665A1 (fr) 2000-11-08
EE200000428A (et) 2001-12-17
WO1999037605A1 (fr) 1999-07-29
NO20003694D0 (no) 2000-07-19
KR20010034317A (ko) 2001-04-25

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Legal Events

Date Code Title Description
FZDE Discontinued