CA2318394A1 - Nouveaux agents antibacteriens - Google Patents

Nouveaux agents antibacteriens Download PDF

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Publication number
CA2318394A1
CA2318394A1 CA002318394A CA2318394A CA2318394A1 CA 2318394 A1 CA2318394 A1 CA 2318394A1 CA 002318394 A CA002318394 A CA 002318394A CA 2318394 A CA2318394 A CA 2318394A CA 2318394 A1 CA2318394 A1 CA 2318394A1
Authority
CA
Canada
Prior art keywords
vancomycin
compound
formula
glycopeptide
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002318394A
Other languages
English (en)
Inventor
Qi-Qi Chen
John H. Griffin
Thomas E. Jenkins
J. Kevin Judice
Martin S. Linsell
Yongqui Mu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoviva Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2318394A1 publication Critical patent/CA2318394A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne de nouveaux agents antibactériens qui agissent comme agents multiliaison. Les composés selon l'invention comprennent de 2 à 10 ligands à liaison covalente, chacun desdits ligants étant capable de se lier à un substrat d'enzyme de transglycosylase et, par la même, de moduler les processus/fonctions biologiques dudit substrat.
CA002318394A 1998-02-20 1999-02-22 Nouveaux agents antibacteriens Abandoned CA2318394A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US7551498P 1998-02-20 1998-02-20
US60/075,514 1998-02-20
US7890398P 1998-03-20 1998-03-20
US60/078,903 1998-03-20
US8220998P 1998-04-17 1998-04-17
US60/082,209 1998-04-17
PCT/US1999/003850 WO1999042476A1 (fr) 1998-02-20 1999-02-22 Nouveaux agents antibacteriens

Publications (1)

Publication Number Publication Date
CA2318394A1 true CA2318394A1 (fr) 1999-08-26

Family

ID=27372700

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002318394A Abandoned CA2318394A1 (fr) 1998-02-20 1999-02-22 Nouveaux agents antibacteriens

Country Status (7)

Country Link
EP (1) EP1060189A1 (fr)
AR (1) AR019817A1 (fr)
AU (1) AU3307399A (fr)
CA (1) CA2318394A1 (fr)
FR (1) FR2778184A1 (fr)
IT (1) IT1307018B1 (fr)
WO (1) WO1999042476A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2336445C (fr) 1998-12-23 2011-07-19 Advanced Medicine, Inc. Derives de glycopeptide et compositions pharmaceutiques a base de ces derniers
CN100532392C (zh) 2000-05-02 2009-08-26 施万制药 还原性烷基化方法
US6656694B2 (en) 2001-01-11 2003-12-02 Theravance, Inc. Method for identifying a ligand for a biological substrate
US20030158093A1 (en) * 2001-08-17 2003-08-21 Binyuan Sun Bifunctional glycopeptide antibiotics and combinatorial libararies thereof
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
JP4347799B2 (ja) 2002-05-24 2009-10-21 セラヴァンス， インコーポレーテッド 架橋グリコペプチド−セファロスポリン抗生物質
ATE450540T1 (de) 2003-05-23 2009-12-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
US7067482B2 (en) 2003-07-11 2006-06-27 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2441697A (en) * 1996-04-12 1997-11-07 Eli Lilly And Company Covalently-linked glycopeptide dimers
AU2609297A (en) * 1996-04-12 1997-11-07 Eli Lilly And Company Glycopeptide compounds
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides

Also Published As

Publication number Publication date
AU3307399A (en) 1999-09-06
FR2778184A1 (fr) 1999-11-05
IT1307018B1 (it) 2001-10-23
AR019817A1 (es) 2002-03-20
EP1060189A1 (fr) 2000-12-20
ITTO990134A1 (it) 2000-08-22
WO1999042476A1 (fr) 1999-08-26

Similar Documents

Publication Publication Date Title
CA2336445C (fr) Derives de glycopeptide et compositions pharmaceutiques a base de ces derniers
EP1005356B1 (fr) AGENTS ANTIBACTERIENS Nouveaux
JP4870314B2 (ja) シクロデキストリンを含むグリコペプチド抗生物質組成物
US20070154948A1 (en) Novel antibacterial agents
CA2318394A1 (fr) Nouveaux agents antibacteriens
US6518242B1 (en) Derivatives of glycopeptide antibacterial agents
US20030008812A1 (en) Glycopeptide derivatives
WO2001057071A2 (fr) Derives glycopeptidiques

Legal Events

Date Code Title Description
FZDE Discontinued