WO1999042476A1 - Nouveaux agents antibacteriens - Google Patents

Nouveaux agents antibacteriens Download PDF

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Publication number
WO1999042476A1
WO1999042476A1 PCT/US1999/003850 US9903850W WO9942476A1 WO 1999042476 A1 WO1999042476 A1 WO 1999042476A1 US 9903850 W US9903850 W US 9903850W WO 9942476 A1 WO9942476 A1 WO 9942476A1
Authority
WO
WIPO (PCT)
Prior art keywords
vancomycin
compound
formula
glycopeptide
optionally substituted
Prior art date
Application number
PCT/US1999/003850
Other languages
English (en)
Inventor
Qi-Qi Chon
John H. Griffin
Thomas E. Jenkins
J. Kevin Judice
Martin S. Linsell
Original Assignee
Advanced Medicine, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine, Inc. filed Critical Advanced Medicine, Inc.
Priority to AU33073/99A priority Critical patent/AU3307399A/en
Priority to EP99934285A priority patent/EP1060189A1/fr
Priority to CA002318394A priority patent/CA2318394A1/fr
Publication of WO1999042476A1 publication Critical patent/WO1999042476A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention concerne de nouveaux agents antibactériens qui agissent comme agents multiliaison. Les composés selon l'invention comprennent de 2 à 10 ligands à liaison covalente, chacun desdits ligants étant capable de se lier à un substrat d'enzyme de transglycosylase et, par la même, de moduler les processus/fonctions biologiques dudit substrat.
PCT/US1999/003850 1998-02-20 1999-02-22 Nouveaux agents antibacteriens WO1999042476A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU33073/99A AU3307399A (en) 1998-02-20 1999-02-22 Novel antibacterial agents
EP99934285A EP1060189A1 (fr) 1998-02-20 1999-02-22 Nouveaux agents antibacteriens
CA002318394A CA2318394A1 (fr) 1998-02-20 1999-02-22 Nouveaux agents antibacteriens

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7551498P 1998-02-20 1998-02-20
US60/075,514 1998-02-20
US7890398P 1998-03-20 1998-03-20
US60/078,903 1998-03-20
US8220998P 1998-04-17 1998-04-17
US60/082,209 1998-04-17

Publications (1)

Publication Number Publication Date
WO1999042476A1 true WO1999042476A1 (fr) 1999-08-26

Family

ID=27372700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/003850 WO1999042476A1 (fr) 1998-02-20 1999-02-22 Nouveaux agents antibacteriens

Country Status (7)

Country Link
EP (1) EP1060189A1 (fr)
AR (1) AR019817A1 (fr)
AU (1) AU3307399A (fr)
CA (1) CA2318394A1 (fr)
FR (1) FR2778184A1 (fr)
IT (1) IT1307018B1 (fr)
WO (1) WO1999042476A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6392012B1 (en) 1998-12-23 2002-05-21 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
WO2003015709A2 (fr) * 2001-08-17 2003-02-27 The Trustees Of Princeton University Antibiotiques glycopeptidiques bifonctionnels et banques combinatoires de ceux-ci
WO2003029270A2 (fr) * 2001-08-24 2003-04-10 Theravance, Inc. Procedes de preparation de derives du glycopeptide phosphonate
WO2003031449A2 (fr) * 2001-10-12 2003-04-17 Theravance, Inc. Antibiotiques reticules glycopeptide-cephalosporine
US6656694B2 (en) 2001-01-11 2003-12-02 Theravance, Inc. Method for identifying a ligand for a biological substrate
US6831150B2 (en) 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
US6878686B2 (en) 2002-05-24 2005-04-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7015305B2 (en) 2001-08-24 2006-03-21 Theravance, Inc. Process for preparing glycopeptide derivatives
US7067481B2 (en) 2003-05-23 2006-06-27 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7067482B2 (en) 2003-07-11 2006-06-27 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038706A1 (fr) * 1996-04-12 1997-10-23 Eli Lilly And Company Composes glycopeptidiques
WO1998052589A1 (fr) * 1997-05-20 1998-11-26 Eli Lilly And Company Hexapeptides alkyles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2441697A (en) * 1996-04-12 1997-11-07 Eli Lilly And Company Covalently-linked glycopeptide dimers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038706A1 (fr) * 1996-04-12 1997-10-23 Eli Lilly And Company Composes glycopeptidiques
WO1998052589A1 (fr) * 1997-05-20 1998-11-26 Eli Lilly And Company Hexapeptides alkyles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
XP002900524 *
XP002900525 *

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949681B2 (en) 1998-12-23 2005-09-27 Theravance, Inc. Intermediate for preparing glycopeptide derivatives
US6444786B1 (en) 1998-12-23 2002-09-03 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
US6455669B1 (en) 1998-12-23 2002-09-24 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
US7351791B2 (en) 1998-12-23 2008-04-01 Theravance, Inc. Intermediate for preparing glycopeptide derivatives
US7101964B2 (en) 1998-12-23 2006-09-05 Theravance, Inc. Intermediate for preparing glycopeptide derivatives
US6392012B1 (en) 1998-12-23 2002-05-21 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
US6962970B2 (en) 1998-12-23 2005-11-08 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
US7723470B2 (en) 1998-12-23 2010-05-25 Theravance, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
US6831150B2 (en) 2000-05-02 2004-12-14 Theravance, Inc. Reductive alkylation process
US6656694B2 (en) 2001-01-11 2003-12-02 Theravance, Inc. Method for identifying a ligand for a biological substrate
WO2003015709A2 (fr) * 2001-08-17 2003-02-27 The Trustees Of Princeton University Antibiotiques glycopeptidiques bifonctionnels et banques combinatoires de ceux-ci
WO2003015709A3 (fr) * 2001-08-17 2004-01-29 Univ Princeton Antibiotiques glycopeptidiques bifonctionnels et banques combinatoires de ceux-ci
US8093354B2 (en) 2001-08-24 2012-01-10 Theravance, Inc. Process for preparing glycopeptide phosphonate derivatives
WO2003029270A3 (fr) * 2001-08-24 2003-09-04 Theravance Inc Procedes de preparation de derives du glycopeptide phosphonate
US7728104B2 (en) 2001-08-24 2010-06-01 Theravance, Inc. Process for preparing glycopeptide phosphonate derivatives
US6979723B2 (en) 2001-08-24 2005-12-27 Theravance, Inc. Process for preparing glycopeptide phosphonate derivatives
WO2003029270A2 (fr) * 2001-08-24 2003-04-10 Theravance, Inc. Procedes de preparation de derives du glycopeptide phosphonate
US7015305B2 (en) 2001-08-24 2006-03-21 Theravance, Inc. Process for preparing glycopeptide derivatives
US7301004B2 (en) 2001-08-24 2007-11-27 Theravance, Inc. Process for preparing glycopeptide phosphonate derivatives
US7160984B2 (en) 2001-08-24 2007-01-09 Theravance, Inc. Process for preparing glycopeptide derivatives
US7074890B2 (en) 2001-08-24 2006-07-11 Theravance, Inc. Process for preparing glycopeptide phosphonate derivatives
US7553962B2 (en) 2001-10-12 2009-06-30 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7601690B2 (en) 2001-10-12 2009-10-13 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
CN1329397C (zh) * 2001-10-12 2007-08-01 施万制药 交联的糖肽－头孢菌素抗生素
US8557978B2 (en) 2001-10-12 2013-10-15 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
WO2003031449A2 (fr) * 2001-10-12 2003-04-17 Theravance, Inc. Antibiotiques reticules glycopeptide-cephalosporine
CN100358901C (zh) * 2001-10-12 2008-01-02 施万制药 交联的糖肽-头孢菌素抗生素
US8044195B2 (en) 2001-10-12 2011-10-25 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7341993B2 (en) 2001-10-12 2008-03-11 Theravance, Inc. Cross-linked glycopeptide—cephalosporin antibiotics
WO2003031449A3 (fr) * 2001-10-12 2003-08-28 Theravance Inc Antibiotiques reticules glycopeptide-cephalosporine
AU2002332111B2 (en) * 2001-10-12 2008-04-17 Theravance Biopharma Antibiotics Ip, Llc Cross-linked glycopeptide-cephalosporin antibiotics
US7713931B2 (en) 2001-10-12 2010-05-11 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
HRP20040243B1 (en) * 2001-10-12 2008-07-31 Theravance Cross-linked glycopeptide-cephalosporin antibiotics
US6974797B2 (en) 2001-10-12 2005-12-13 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7655621B2 (en) 2001-10-12 2010-02-02 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7612037B2 (en) 2001-10-12 2009-11-03 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7649080B2 (en) 2001-10-12 2010-01-19 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7405199B2 (en) 2002-05-24 2008-07-29 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US6878686B2 (en) 2002-05-24 2005-04-12 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US6995138B2 (en) 2002-05-24 2006-02-07 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US8084417B2 (en) 2002-05-24 2011-12-27 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7332471B2 (en) 2003-05-23 2008-02-19 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7067481B2 (en) 2003-05-23 2006-06-27 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US8314217B2 (en) 2003-05-23 2012-11-20 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7067482B2 (en) 2003-07-11 2006-06-27 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
US7279458B2 (en) 2003-07-11 2007-10-09 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics

Also Published As

Publication number Publication date
ITTO990134A1 (it) 2000-08-22
EP1060189A1 (fr) 2000-12-20
CA2318394A1 (fr) 1999-08-26
AU3307399A (en) 1999-09-06
AR019817A1 (es) 2002-03-20
FR2778184A1 (fr) 1999-11-05
IT1307018B1 (it) 2001-10-23

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