CA2318345A1 - Composition with high efficiency skin protection from damaging effects of ultraviolet light - Google Patents
Composition with high efficiency skin protection from damaging effects of ultraviolet light Download PDFInfo
- Publication number
- CA2318345A1 CA2318345A1 CA002318345A CA2318345A CA2318345A1 CA 2318345 A1 CA2318345 A1 CA 2318345A1 CA 002318345 A CA002318345 A CA 002318345A CA 2318345 A CA2318345 A CA 2318345A CA 2318345 A1 CA2318345 A1 CA 2318345A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- vitamin
- sunscreen
- skin
- seed extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract 92
- 230000000254 damaging effect Effects 0.000 title 1
- 239000000516 sunscreening agent Substances 0.000 claims abstract 29
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract 24
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract 24
- 229920002498 Beta-glucan Polymers 0.000 claims abstract 24
- 229940087603 grape seed extract Drugs 0.000 claims abstract 24
- 235000002532 grape seed extract Nutrition 0.000 claims abstract 24
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract 24
- 102000019197 Superoxide Dismutase Human genes 0.000 claims abstract 23
- 108010012715 Superoxide dismutase Proteins 0.000 claims abstract 23
- 239000003963 antioxidant agent Substances 0.000 claims abstract 23
- 235000006708 antioxidants Nutrition 0.000 claims abstract 23
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract 22
- 230000000475 sunscreen effect Effects 0.000 claims abstract 18
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract 17
- 229940101267 panthenol Drugs 0.000 claims abstract 17
- 235000020957 pantothenol Nutrition 0.000 claims abstract 17
- 239000011619 pantothenol Substances 0.000 claims abstract 17
- 230000003078 antioxidant effect Effects 0.000 claims abstract 15
- 230000000699 topical effect Effects 0.000 claims abstract 15
- 235000019155 vitamin A Nutrition 0.000 claims abstract 13
- 239000011719 vitamin A Substances 0.000 claims abstract 13
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract 12
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract 12
- 230000005855 radiation Effects 0.000 claims abstract 12
- 239000011718 vitamin C Substances 0.000 claims abstract 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract 12
- 239000011709 vitamin E Substances 0.000 claims abstract 12
- 235000019165 vitamin E Nutrition 0.000 claims abstract 12
- 229940045997 vitamin a Drugs 0.000 claims abstract 12
- 229930003427 Vitamin E Natural products 0.000 claims abstract 11
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract 11
- 229940046009 vitamin E Drugs 0.000 claims abstract 11
- 239000000839 emulsion Substances 0.000 claims abstract 8
- 230000003833 cell viability Effects 0.000 claims abstract 5
- 238000004519 manufacturing process Methods 0.000 claims abstract 4
- 239000007762 w/o emulsion Substances 0.000 claims abstract 3
- 230000006378 damage Effects 0.000 claims abstract 2
- 230000007423 decrease Effects 0.000 claims abstract 2
- 210000001339 epidermal cell Anatomy 0.000 claims abstract 2
- 230000009931 harmful effect Effects 0.000 claims abstract 2
- 239000006210 lotion Substances 0.000 claims abstract 2
- 230000003020 moisturizing effect Effects 0.000 claims abstract 2
- 239000003995 emulsifying agent Substances 0.000 claims 25
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 17
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 claims 14
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 claims 14
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 12
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims 12
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 12
- 229940108325 retinyl palmitate Drugs 0.000 claims 12
- 235000019172 retinyl palmitate Nutrition 0.000 claims 12
- 239000011769 retinyl palmitate Substances 0.000 claims 12
- 229940042585 tocopherol acetate Drugs 0.000 claims 12
- 239000003755 preservative agent Substances 0.000 claims 11
- 239000003205 fragrance Substances 0.000 claims 10
- 229940085262 cetyl dimethicone Drugs 0.000 claims 7
- 239000003906 humectant Substances 0.000 claims 7
- 239000008213 purified water Substances 0.000 claims 7
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 6
- 229960001679 octinoxate Drugs 0.000 claims 6
- OQILCOQZDHPEAZ-UHFFFAOYSA-N octyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 claims 6
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims 6
- 229960001173 oxybenzone Drugs 0.000 claims 6
- 239000003352 sequestering agent Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 5
- 230000037380 skin damage Effects 0.000 claims 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 4
- 239000003599 detergent Substances 0.000 claims 4
- 239000003974 emollient agent Substances 0.000 claims 4
- 239000002562 thickening agent Substances 0.000 claims 4
- WCOXQTXVACYMLM-UHFFFAOYSA-N 2,3-bis(12-hydroxyoctadecanoyloxy)propyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC(O)CCCCCC)COC(=O)CCCCCCCCCCC(O)CCCCCC WCOXQTXVACYMLM-UHFFFAOYSA-N 0.000 claims 3
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 3
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims 3
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 claims 3
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 claims 3
- 229960002986 dinoprostone Drugs 0.000 claims 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 3
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims 3
- 229940068171 ethyl hexyl salicylate Drugs 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 229940100463 hexyl laurate Drugs 0.000 claims 3
- 239000004200 microcrystalline wax Substances 0.000 claims 3
- 235000019808 microcrystalline wax Nutrition 0.000 claims 3
- 229940100518 polyglyceryl-4 isostearate Drugs 0.000 claims 3
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims 2
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 claims 2
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 claims 2
- 241000208680 Hamamelis mollis Species 0.000 claims 2
- WYWZRNAHINYAEF-AWEZNQCLSA-N [(2s)-2-ethylhexyl] 4-(dimethylamino)benzoate Chemical compound CCCC[C@H](CC)COC(=O)C1=CC=C(N(C)C)C=C1 WYWZRNAHINYAEF-AWEZNQCLSA-N 0.000 claims 2
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 claims 2
- 229960005193 avobenzone Drugs 0.000 claims 2
- YEAYGXLRPMKZBP-KQGICBIGSA-N bis(2-hydroxyethyl)azanium;(e)-3-(4-methoxyphenyl)prop-2-enoate Chemical compound OCCNCCO.COC1=CC=C(\C=C\C(O)=O)C=C1 YEAYGXLRPMKZBP-KQGICBIGSA-N 0.000 claims 2
- 239000006172 buffering agent Substances 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- 230000003750 conditioning effect Effects 0.000 claims 2
- 229940086555 cyclomethicone Drugs 0.000 claims 2
- 229960004960 dioxybenzone Drugs 0.000 claims 2
- SNPLKNRPJHDVJA-UHFFFAOYSA-N dl-panthenol Chemical compound OCC(C)(C)C(O)C(=O)NCCCO SNPLKNRPJHDVJA-UHFFFAOYSA-N 0.000 claims 2
- 229960004881 homosalate Drugs 0.000 claims 2
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical group C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims 2
- 229960000601 octocrylene Drugs 0.000 claims 2
- IIGMITQLXAGZTL-UHFFFAOYSA-N octyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCC IIGMITQLXAGZTL-UHFFFAOYSA-N 0.000 claims 2
- 229960002638 padimate o Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 claims 2
- 229960000368 sulisobenzone Drugs 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 229960005196 titanium dioxide Drugs 0.000 claims 2
- 239000004408 titanium dioxide Substances 0.000 claims 2
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 claims 2
- 229940118846 witch hazel Drugs 0.000 claims 2
- 239000011787 zinc oxide Substances 0.000 claims 2
- 229960001296 zinc oxide Drugs 0.000 claims 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 229940049657 cyclomethicone 5 Drugs 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- SOXAGEOHPCXXIO-DVOMOZLQSA-N menthyl anthranilate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1N SOXAGEOHPCXXIO-DVOMOZLQSA-N 0.000 claims 1
- 229960002248 meradimate Drugs 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 229960003921 octisalate Drugs 0.000 claims 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 claims 1
- 239000000419 plant extract Substances 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000003642 reactive oxygen metabolite Substances 0.000 claims 1
- 230000037072 sun protection Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 230000002411 adverse Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 239000000344 soap Substances 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A topical antioxidant composition for the protection of skin from damage caused by ultraviolet radiation. The composition includes a first component (such as beta glucan or grape seed extract) that increases cellular viability of epidermal cells, and a second component that decreases the production of inflammatory mediators, such as prostaglandins, in those cells. In a particular embodiment, the composition includes beta glucan in combination with panthenol, grape seed extract, vitamin C and superoxide dismutase, which exhibit a synergistic effect in protecting the skin from the adverse effects of ultraviolet radiation. In another embodiment, the composition further includes Vitamin A and Vitamin E. In a further embodiment, the composition includes a combination of one or more antioxidants and sunscreen agents in an emulsion, such as water-in-oil (W/O) emulsion, which provides superior protection of the skin against the harmful effects of ultraviolet radiation.
The antioxidant compositions are incorporated into sunscreen products, soap, moisturizing lotions, skin toners, and other skin care products.
The antioxidant compositions are incorporated into sunscreen products, soap, moisturizing lotions, skin toners, and other skin care products.
Claims (58)
1. A method of inhibiting skin damage induced by ultraviolet radiation, the method comprising:
applying topically to the skin a composition comprising beta glucan in a sufficient amount to reduce skin damage caused by exposure to ultraviolet radiation.
applying topically to the skin a composition comprising beta glucan in a sufficient amount to reduce skin damage caused by exposure to ultraviolet radiation.
2. The method of claim 1, wherein the composition further comprises panthenol, grape seed extract, Vitamin C, and superoxide dismutase.
3. The method of claim 1, wherein the composition further comprises Vitamin A and Vitamin E.
4. The method of claim 1, wherein the composition comprises at least about 0.005 % beta glucan.
5. The method of claim 4, wherein the composition comprises about 0.005-5 % beta glucan.
6. The method of claim 2, wherein the composition comprises at least about 0.005 % panthenol, 0.00001 % grape seed extract, 0.0001 % Vitamin C, and 0.0001 % superoxide dismutase.
7. The method of claim 6, wherein the composition comprises about 0.005-5 % panthenol, 0.00001-1 % grape seed extract, 0.0001-3 % Vitamin C, and 0.0001-1 % superoxide dismutase.
8. The method of claim 7, wherein the composition further comprises at least about 0.0005 % Vitamin A, and at least 0.05 % Vitamin E.
9. The method of claim 8, wherein the composition comprises about 0.0005-0.5000% Vitamin A and 0.0500-30% Vitamin E.
10. The method of claim 1, further comprising applying a mixture of one or more sunscreen agents and one or more antioxidants to the skin prior to exposure to ultraviolet radiation, wherein the mixture also contains a polyorganosiloxane emulsifier that enhances an SPF of the mixture.
11. The method of claim 1, wherein the composition is provided in an emulsion that enhances an SPF of the composition.
12. The method of claim 2, wherein the composition is provided in an emulsion that enhances an SPF of the composition.
13. The method of claim 3, wherein the composition is provided in an emulsion that enhances an SPF of the composition.
14. The method of claim 1, wherein the composition is provided in an emulsion that enhances an SPF of the composition.
15. The method of claim 1, wherein the emulsion is a polyorganosiloxane emulsion.
16. A topical composition for reducing skin damage induced by ultraviolet radiation, the composition comprising:
beta glucan in a sufficient amount to reduce the skin damage when applied topically; and at least one other skin protectant that reduces the skin damage caused by ultraviolet light.
beta glucan in a sufficient amount to reduce the skin damage when applied topically; and at least one other skin protectant that reduces the skin damage caused by ultraviolet light.
17. The topical composition of claim 16, wherein the other skin protectant is selected from the group consisting of one or more of panthenol, grape seed extract, Vitamin C and superoxide dismutase in a sufficient amount to reduce production of PGE2, or increase cellular viability, in the skin when applied topically.
18. The composition of claim 16, wherein the composition further comprises an antioxidant selected from the group consisting of one or both of Vitamin A and Vitamin E in a sufficient amount to reduce reactive oxygen species in the skin when applied topically.
I9: The topical composition of claim 17, wherein the composition comprises about 0.005-5% beta glucan, 0.005-5% panthenol, 0.00001-1% grape seed extract, 0.0001-3% Vitamin C, and 0.0001-1% superoxide dismutase.
20. The topical composition of claim 17, wherein the composition comprises about 0.0005-0.5000% Vitamin A and 0.0500-30% Vitamin E.
21. The topical composition of claim 17, wherein the composition further comprises at least about 0.0005% Vitamin A, and at least 0.01% Vitamin E.
22. The topical composition of claim 19, wherein the Vitamin C is in the form of magnesium ascorbyl phosphate.
23. The topical composition of claim 20, wherein the Vitamin A is in the form of Vitamin A palmitate and the Vitamin E is in the form of Vitamin E
acetate.
acetate.
24. The topical composition of claim 17, wherein the other skin protectant is a protectant that improves cellular viability following exposure to ultraviolet radiation.
25. The topical composition of claim 18, further comprising a sunscreen, and an emulsifier in a sufficient amount to enhance an SPF of the composition.
26. The topical composition of claim 23, wherein the emulsifier is a water-in-oil polyorangosiloxane emulsifier.
27. The topical composition of claim 16, wherein the composition further comprises an antioxidant that includes lipid soluble and water soluble components; a sunscreen; and an emulsifier to emulsify a sufficient amount of the antioxidant and the sunscreen to provide a sun-protective composition.
28. A topical composition for protecting skin against damage from ultraviolet radiation, comprising:
beta glucan, panthenol, grape seed extract, Vitamin C and superoxide dismutase in a sufficient amount to increase cellular viability and reduce the production of PGE2 in the skin to which the composition is applied, that is exposed to ultraviolet radiation.
beta glucan, panthenol, grape seed extract, Vitamin C and superoxide dismutase in a sufficient amount to increase cellular viability and reduce the production of PGE2 in the skin to which the composition is applied, that is exposed to ultraviolet radiation.
29. The topical composition of claim 28, further comprising Vitamin A and Vitamin E in sufficient amounts to have an antioxidant effect on the skin when topically applied.
30. The composition of claim 28, wherein the composition comprises by weight about:
0.005-5% beta glucan;
0.005-5% panthenol;
0.00001-1% grape seed extract;
0.0001-3% Vitamin C; and 0.0001-1% superoxide dismutase.
0.005-5% beta glucan;
0.005-5% panthenol;
0.00001-1% grape seed extract;
0.0001-3% Vitamin C; and 0.0001-1% superoxide dismutase.
31. The composition of claim 28, comprising by weight at least about:
0.005% beta glucan;
0.005% panthenol;
0.00001% grape seed extract;
0.0001% Vitamin C; and 0.0001% superoxide dismutase.
0.005% beta glucan;
0.005% panthenol;
0.00001% grape seed extract;
0.0001% Vitamin C; and 0.0001% superoxide dismutase.
32. The composition of claim 31, further comprising by weight at least about 0.0005% Vitamin A, and at least 0.05% Vitamin E.
33. The composition of claim 32, further comprising by weight about:
0.0005-0.5000% Vitamin A; and 0.0100-30% Vitamin E.
0.0005-0.5000% Vitamin A; and 0.0100-30% Vitamin E.
34. The composition of claim 16, in an aqueous or non-aqueous solution, suspension, a water-in-oil or oil-in-water emulsion.
35. The composition of claim 16 in a skin toner composition, a moisturizing lotion, a sunscreen composition, a skin cleanser or other skin treatment composition.
36. A topical antioxidant composition comprising a first component that increases cellular viability of epidermal cells, and a second component that decreases the production of PGE2.
37. A composition comprising:
an antioxidant that includes lipid soluble and water soluble components;
a sunscreen; and an emulsifier to emulsify a sufficient amount of the antioxidant and the sunscreen to provide a sun-protective composition.
an antioxidant that includes lipid soluble and water soluble components;
a sunscreen; and an emulsifier to emulsify a sufficient amount of the antioxidant and the sunscreen to provide a sun-protective composition.
38. The composition of claim 37, wherein the emulsifier is a polyorganosiloxane emulsifier that enhances a sun protection factor (SPF) of the composition.
39. The composition of claim 37, wherein the composition comprises a low level of sunscreen agent in the sunscreen, and the antioxidant comprises a mixture of antioxidants in a water-in-oil polyorganosiloxane emulsion.
40. A composition of claim 37 in which the sunscreen comprises one or more agents selected from the group of: ethylhexyl methoxycinnamate, DEA
methoxycinnamate, Padimate O, ethylhexyl salicylate, homosalate, TEA
salicylate, oxybenzone, dioxybenzone, sulisobenzone, avobenzone, octocrylene, titanium dioxide, zinc oxide or menthyl anthranilate.
methoxycinnamate, Padimate O, ethylhexyl salicylate, homosalate, TEA
salicylate, oxybenzone, dioxybenzone, sulisobenzone, avobenzone, octocrylene, titanium dioxide, zinc oxide or menthyl anthranilate.
41. The composition of claim 37, wherein the sunscreen comprises at least one UVA sunscreen agent selected from the group of oxybenzone, dioxybenzone, sulisobenzone, avobenzone or zinc oxide, and at least one UVB
sunscreen agent, selected from the group of ethylhexyl methoxycinnamate, DEA
methoxycinnamate, Padimate O, ethylhexyl salicylate, homosalate, TEA
salicylate, octocrylene or titanium dioxide.
sunscreen agent, selected from the group of ethylhexyl methoxycinnamate, DEA
methoxycinnamate, Padimate O, ethylhexyl salicylate, homosalate, TEA
salicylate, octocrylene or titanium dioxide.
42. The composition of claim 37, wherein the sunscreen comprises at least oxybenzone and at least one of ethylhexyl methoxycinnamate and octyl salicylate.
43. The composition of claim 37 in which the lipid soluble component of the antioxidant comprises one or both of Vitamins and A and E.
44. The composition of claim 37 in which the water soluble component of the antioxidant comprises one or more antioxidants selected from the group of magnesium ascorbyl phosphate, DL panthenol, beta glucan, grape seed extract and superoxide dismutase.
45. The composition of claim 37 in which the antioxidant comprises a mixture of antioxidants comprising Vitamins A and E or their esters, magnesium ascorbyl phosphate, DL panthenol, beta glucan, grape seed extract and superoxide dismutase.
46. The composition of claim 37, wherein the composition is at least 50% water, and the emulsifier includes 1-12% of an emulsification system that includes cetyl dimethicone copolyol, and the sunscreen agent and antioxidant are present in an amount sufficient to maintain the SPF of the composition at a value greater than about 15.
47. The composition of claim 37, wherein the sum of the SPF values of the antioxidant and sunscreen components tested separately is no more than about 70% of the SPF value of the sunscreen components tested together.
48. A method of improving an SPF value of a formulation for protecting skin from harmful effects of ultraviolet radiation, comprising combining one or more lipid soluble antioxidants with one or more water soluble antioxidants and one or more sunscreen agents, in the presence of an organopolysiloxane emulsifier, the formulation having the antioxidants, sunscreen agents and emulsifier present in an amount sufficient to enhance the SPF value of the formulation to greater than the sum of the SPF value of the antioxidants and sunscreen agents apart.
49. An ultraviolet radiation protective composition, comprising .about 0.0002-4% of a lipid soluble sunscreen component that includes Vitamin A and Vitamin C; about 0.004-5% of a water soluble sunscreen component that includes Vitamin C, beta glucan, grape seed extract, and superoxide dismutase; an emulsifier; and a sunscreen component that contains less than about 12 % of an non-particulate sunscreen agent that is substantially free of metal oxides.
50. The composition of claim 49, wherein the emulsifier comprises a polyalkylsiloxane.
51. The composition of claim 49, wherein the emulsifier further comprises a fatty alcohol.
52. The composition of claim 49, wherein the emulsifier comprises polyglyceryl-4-isostearate, cetyl dimethicone copolyol, and hexyl laurate.
53. A composition comprising about:
Primary emulsifier 1 - 9%
Ethylhexyl Methoxycinnamate 0.1 - 7.5%
Oxybenzone 0.5 - 6%
C12-15 alkyl benzoate 0.5 - 5%
Octyl Palmitate 0.1 - 10%
Octyl Stearate 0.1 - 8%
Cetyl Dimethicone 0.01 - 5%
Castorwax MP-80 0.01 - 4%
Microcrystalline Wax 0.01 - 4%
Vitamin E Acetate 0.0001 - 2%
Vitamin A Palmitate 0.0001 - 2%
Cyclomethicone 0.5 - 10%
Water to 100% to 100%
Magnesium Ascorbyl Phosphate 0.0001 - 2%
Sodium Chloride 0.0001 - 2%
Disodium EDTA 0.0001 - 1%
Beta Glucan 0.0001 - 1%
Grape Seed Extract 0.0001 - 1%
Superoxide Dismutase 0.0001 - 1%
Fragrance and Preservatives q.s.1 q.s.
Total 100% 100%
wherein the primary emulsifier comprises cetyl dimethicone colpolyol.
Primary emulsifier 1 - 9%
Ethylhexyl Methoxycinnamate 0.1 - 7.5%
Oxybenzone 0.5 - 6%
C12-15 alkyl benzoate 0.5 - 5%
Octyl Palmitate 0.1 - 10%
Octyl Stearate 0.1 - 8%
Cetyl Dimethicone 0.01 - 5%
Castorwax MP-80 0.01 - 4%
Microcrystalline Wax 0.01 - 4%
Vitamin E Acetate 0.0001 - 2%
Vitamin A Palmitate 0.0001 - 2%
Cyclomethicone 0.5 - 10%
Water to 100% to 100%
Magnesium Ascorbyl Phosphate 0.0001 - 2%
Sodium Chloride 0.0001 - 2%
Disodium EDTA 0.0001 - 1%
Beta Glucan 0.0001 - 1%
Grape Seed Extract 0.0001 - 1%
Superoxide Dismutase 0.0001 - 1%
Fragrance and Preservatives q.s.1 q.s.
Total 100% 100%
wherein the primary emulsifier comprises cetyl dimethicone colpolyol.
54. The composition of claim 53, comprising about:
Primary emulsifier 5%
Ethylhexyl Methoxycinnamate 3%
Oxybenzone 2%
C12-15 alkyl benzoate 2%
Octyl Palmitate 4.5%
Octyl Stearate 3%
Cetyl Dimethicone 1%
Castorwax MP-80 0.8%
Microcrystalline Wax 1.2%
Vitamin E Acetate 0.1%
Vitamin A Palmitate 0.05%
Cyclomethicone 5%
Water to 100%
Magnesium Ascorbyl Phosphate 0.004%
Sodium Chloride 0.3%
Disodium EDTA 0.1%
Beta Glucan 0.1%
Grape Seed Extract 0.5%
Superoxide Dismutase 0.004%
Fragrance and Preservatives q.s.
Total 100%
or Primary emulsifier 8%
Ethylhexyl Methoxycinnamate~~~7%
Ethylhexyl Salicylate ~~~3%
Oxybenzone ~~~2%
C12-15 alkyl benzoate ~~~6%
Octyl Palmitate ~~~5%
Cetyl Dimethicone~~~ 1%
Castorwax MP-80 ~~~0.8%
Microcrystalline Wax 1.2%
Vitamin E Acetate 0.1%
Vitamin A Palmitate 0.05%
Cyclomethicone 1%
Water to 100%
Magnesium Ascorbyl Phosphate 0.004%
Sodium Chloride 0.3%
Disodium EDTA 0.1%
Beta Glucan (Camamino) 0.1%
Grape Seed Extract 0.5%
Superoxide Dismutase 0.004%
Fragrance and Preservatives q.s.
Total 100%
wherein the primary emulsifier further comprises polyglyceryl-4- isostearate and hexyl laurate.
Primary emulsifier 5%
Ethylhexyl Methoxycinnamate 3%
Oxybenzone 2%
C12-15 alkyl benzoate 2%
Octyl Palmitate 4.5%
Octyl Stearate 3%
Cetyl Dimethicone 1%
Castorwax MP-80 0.8%
Microcrystalline Wax 1.2%
Vitamin E Acetate 0.1%
Vitamin A Palmitate 0.05%
Cyclomethicone 5%
Water to 100%
Magnesium Ascorbyl Phosphate 0.004%
Sodium Chloride 0.3%
Disodium EDTA 0.1%
Beta Glucan 0.1%
Grape Seed Extract 0.5%
Superoxide Dismutase 0.004%
Fragrance and Preservatives q.s.
Total 100%
or Primary emulsifier 8%
Ethylhexyl Methoxycinnamate~~~7%
Ethylhexyl Salicylate ~~~3%
Oxybenzone ~~~2%
C12-15 alkyl benzoate ~~~6%
Octyl Palmitate ~~~5%
Cetyl Dimethicone~~~ 1%
Castorwax MP-80 ~~~0.8%
Microcrystalline Wax 1.2%
Vitamin E Acetate 0.1%
Vitamin A Palmitate 0.05%
Cyclomethicone 1%
Water to 100%
Magnesium Ascorbyl Phosphate 0.004%
Sodium Chloride 0.3%
Disodium EDTA 0.1%
Beta Glucan (Camamino) 0.1%
Grape Seed Extract 0.5%
Superoxide Dismutase 0.004%
Fragrance and Preservatives q.s.
Total 100%
wherein the primary emulsifier further comprises polyglyceryl-4- isostearate and hexyl laurate.
55. The composition of claim 53 wherein the primary emulsifier comprises polyglyceryl-4- isostearate, cetyl dimethicone copolyol and hexyl laurate.
56. A composition comprising about:
(a) Percent by weight Purified Water 19 - 98.7 Surfactants 0.5 - 5 Witch Hazel Distillate 0.01 - 20 Humectant 0.5 - 5 Fragrance 0.001 - 1 Preservatives 0.2 - 3 Sequestering Agent 0.01 - 0.5 Menthol 0.005 - 1 Vitamin A Palmitate 0.0005 - 0.5 Vitamin E Acetate 0.05 - 30 Magnesium Ascorbyl Phosphate 0.0001 - 3 Beta Glucan 0.005 - 5 Superoxide Dismutase 0.0001 - 1 Grape Seed Extract ~~~0.00001- 1 Panthenol ~~~~0.005 - 5 Total ~~~~~100%
or (b) Percent by weight Purified Water ~~0 - 98 O/W Emulsifiers 1 - 12 Humectants ~~0.5 - 15 Fragrance ~~0.001 - 1 Preservatives ~~0.1 - 3 Sequestering Agent ~~0.01 - 0.5 Emollients ~~0.5 - 30 Thickeners ~~0.01 - 1 Vitamin A Palmitate ~~0.0005 - 0.5 Vitamin E Acetate ~~0.05 - 30 Magnesium Ascorbyl Phosphate 0.0001 - 3 Beta Glucan ~~0.005 - 5 Superoxide Dismutase ~~0.0001 - 1 Grape Seed Extract ~~0.001 - 1 Panthenol ~~0.005 - 5 Total 100%
or (c) Percent by weight Purred Water ~~0 - 98 W/O Emulsifiers ~~1- 10 Humectants ~~0 - 10 Fragrance ~~0 - 0.5 Preservatives ~~0.1 - 7 Sequestering Agent 0.01 - 0.5 Emollients and Sunscreen agents 10 - 60 Salt ~~0.01 - 1 Vitamin A Palmitate ~~0.0005 - 0.5 Vitamin E Acetate ~~0.01 - 30 Magnesium Ascorbyl Phosphate~~0.0001 - 3 Beta Glucan ~~0.005 - 5 Superoxide Dismutase ~~0.0001 - 1 Grape Seed Extract ~~0.001 - 1 Panthenol ~~0.005 - 5 Total 100%
or (d) Percent by weight Purified Water ~~0 - 15 Detergents and Cleansing Agents ~32 - 98 Buffering Agents ~~~1 - 3 Humectants and Skin Conditioning Agents 0.5 - 5 Fragrance ~~~0.001 - 1 Preservatives ~~~0.01 - 2 Thickeners and Coloring Agents~~0.01 - 30 Vitamin A Palmitate ~~~0.0005 - 0.5 Vitamin E Acetate ~~~0.01 - 30 Magnesium Ascorbyl Phosphate~~~0.0001 - 3 Beta Glucan ~~~0.005 - 5 Superoxide Dismutase ~~~0.0001 - 1 Grape Seed Extract ~~~0.001 - 1 Panthenol ~~~0.005 - 5 Total ~~~100%
or (e) Percent by Weight Purified Water ~~9.34 Detergents and Cleansing Agents~~48.2 Buffering Agents ~~2.48 Humectants and Skin Conditioning Agents 13 Fragrance 0.24 Preservatives 0.09 Thickeners and Colorants ~~25.66 Vitamin A Palmitate ~~0.005 Vitamin E Acetate ~~0.49 Magnesium Ascorbyl Phosphate ~~0,004 Beta Glucan ~~0.01 Superoxide Dismutase ~~0.004 Grape Seed Extract ~~0.195 Panthenol ~~0.195 Total ~~100%
or (f) Percent by weight Purified Water ~~~80 O/W Emulsifiers ~~~11 Humectants ~~~5 Fragrance ~~~0.05 Preservatives ~~~2.7 Sequestering Agent ~~~0.1 Emollients ~~~12 Thickeners ~~0.3 Vitamin A Palmitate ~~0.05 Vitamin E Acetate ~~1 Magnesium Ascorbyl Phosphate~~0.25 Beta Glucan ~~1 Superoxide Dismutase ~~0.04 Grape Seed Extract ~~0.005 Panthenol ~~2 Total 100%
or (g) Percent by weight Purified Water ~~80 Surfactants ~~2 Witch Hazel Distillate ~~15 Humectant ~~1 Fragrance ~~0.035 Preservatives ~~1.9 Sequestering Agent ~~0.1 Menthol ~~0.01 Plant Extracts ~~0.07 Vitamin A Palmitate ~~0.005 Vitamin E Acetate ~~0.1 Magnesium Ascorbyl Phosphate~~0.004 Beta Glucan ~~0.1 Superoxide Dismutase ~~0,004 Grape Seed Extract ~~0.0001 Panthenol ~~0.2 Total ~~100%
(a) Percent by weight Purified Water 19 - 98.7 Surfactants 0.5 - 5 Witch Hazel Distillate 0.01 - 20 Humectant 0.5 - 5 Fragrance 0.001 - 1 Preservatives 0.2 - 3 Sequestering Agent 0.01 - 0.5 Menthol 0.005 - 1 Vitamin A Palmitate 0.0005 - 0.5 Vitamin E Acetate 0.05 - 30 Magnesium Ascorbyl Phosphate 0.0001 - 3 Beta Glucan 0.005 - 5 Superoxide Dismutase 0.0001 - 1 Grape Seed Extract ~~~0.00001- 1 Panthenol ~~~~0.005 - 5 Total ~~~~~100%
or (b) Percent by weight Purified Water ~~0 - 98 O/W Emulsifiers 1 - 12 Humectants ~~0.5 - 15 Fragrance ~~0.001 - 1 Preservatives ~~0.1 - 3 Sequestering Agent ~~0.01 - 0.5 Emollients ~~0.5 - 30 Thickeners ~~0.01 - 1 Vitamin A Palmitate ~~0.0005 - 0.5 Vitamin E Acetate ~~0.05 - 30 Magnesium Ascorbyl Phosphate 0.0001 - 3 Beta Glucan ~~0.005 - 5 Superoxide Dismutase ~~0.0001 - 1 Grape Seed Extract ~~0.001 - 1 Panthenol ~~0.005 - 5 Total 100%
or (c) Percent by weight Purred Water ~~0 - 98 W/O Emulsifiers ~~1- 10 Humectants ~~0 - 10 Fragrance ~~0 - 0.5 Preservatives ~~0.1 - 7 Sequestering Agent 0.01 - 0.5 Emollients and Sunscreen agents 10 - 60 Salt ~~0.01 - 1 Vitamin A Palmitate ~~0.0005 - 0.5 Vitamin E Acetate ~~0.01 - 30 Magnesium Ascorbyl Phosphate~~0.0001 - 3 Beta Glucan ~~0.005 - 5 Superoxide Dismutase ~~0.0001 - 1 Grape Seed Extract ~~0.001 - 1 Panthenol ~~0.005 - 5 Total 100%
or (d) Percent by weight Purified Water ~~0 - 15 Detergents and Cleansing Agents ~32 - 98 Buffering Agents ~~~1 - 3 Humectants and Skin Conditioning Agents 0.5 - 5 Fragrance ~~~0.001 - 1 Preservatives ~~~0.01 - 2 Thickeners and Coloring Agents~~0.01 - 30 Vitamin A Palmitate ~~~0.0005 - 0.5 Vitamin E Acetate ~~~0.01 - 30 Magnesium Ascorbyl Phosphate~~~0.0001 - 3 Beta Glucan ~~~0.005 - 5 Superoxide Dismutase ~~~0.0001 - 1 Grape Seed Extract ~~~0.001 - 1 Panthenol ~~~0.005 - 5 Total ~~~100%
or (e) Percent by Weight Purified Water ~~9.34 Detergents and Cleansing Agents~~48.2 Buffering Agents ~~2.48 Humectants and Skin Conditioning Agents 13 Fragrance 0.24 Preservatives 0.09 Thickeners and Colorants ~~25.66 Vitamin A Palmitate ~~0.005 Vitamin E Acetate ~~0.49 Magnesium Ascorbyl Phosphate ~~0,004 Beta Glucan ~~0.01 Superoxide Dismutase ~~0.004 Grape Seed Extract ~~0.195 Panthenol ~~0.195 Total ~~100%
or (f) Percent by weight Purified Water ~~~80 O/W Emulsifiers ~~~11 Humectants ~~~5 Fragrance ~~~0.05 Preservatives ~~~2.7 Sequestering Agent ~~~0.1 Emollients ~~~12 Thickeners ~~0.3 Vitamin A Palmitate ~~0.05 Vitamin E Acetate ~~1 Magnesium Ascorbyl Phosphate~~0.25 Beta Glucan ~~1 Superoxide Dismutase ~~0.04 Grape Seed Extract ~~0.005 Panthenol ~~2 Total 100%
or (g) Percent by weight Purified Water ~~80 Surfactants ~~2 Witch Hazel Distillate ~~15 Humectant ~~1 Fragrance ~~0.035 Preservatives ~~1.9 Sequestering Agent ~~0.1 Menthol ~~0.01 Plant Extracts ~~0.07 Vitamin A Palmitate ~~0.005 Vitamin E Acetate ~~0.1 Magnesium Ascorbyl Phosphate~~0.004 Beta Glucan ~~0.1 Superoxide Dismutase ~~0,004 Grape Seed Extract ~~0.0001 Panthenol ~~0.2 Total ~~100%
57. A sunscreen product for the skin, comprising about:
Percent by weight Purified Water ~~62 W/O Emulsifiers~~~6 Preservatives ~~3.65 Sequestering Agent ~~0.1 Emollients and Sunscreens Agents 27.75 Salt ~~0.3 Vitamin A Palmitate ~~0.005 Vitamin E Acetate ~~0.1 Magnesium Ascorbyl Phosphate~~0.004 Beta Glucan ~~0.1 Superoxide Dismutase ~~0.004 Grape Seed Extract ~~0.0005 Panthenol ~~~~0.2 Total ~~~~100%
Percent by weight Purified Water ~~62 W/O Emulsifiers~~~6 Preservatives ~~3.65 Sequestering Agent ~~0.1 Emollients and Sunscreens Agents 27.75 Salt ~~0.3 Vitamin A Palmitate ~~0.005 Vitamin E Acetate ~~0.1 Magnesium Ascorbyl Phosphate~~0.004 Beta Glucan ~~0.1 Superoxide Dismutase ~~0.004 Grape Seed Extract ~~0.0005 Panthenol ~~~~0.2 Total ~~~~100%
58. Any of the compositions of claim 56, further comprising a suncreen agent, and apolyorganosiloxane water-in-oil emulsion that increases an SPF of the composition.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/998,238 US6036946A (en) | 1997-12-24 | 1997-12-24 | Methods for protecting skin from damaging effects of ultraviolet light |
| US08/998,238 | 1998-07-10 | ||
| US09/113,815 US6015548A (en) | 1998-07-10 | 1998-07-10 | High efficiency skin protection formulation with sunscreen agents and antioxidants |
| US09/113,815 | 1998-07-10 | ||
| PCT/US1998/027433 WO1999033439A1 (en) | 1997-12-24 | 1998-12-22 | Composition with high efficiency skin protection from damaging effects of ultraviolet light |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2318345A1 true CA2318345A1 (en) | 1999-07-08 |
| CA2318345C CA2318345C (en) | 2011-06-07 |
Family
ID=26811508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2318345A Expired - Lifetime CA2318345C (en) | 1997-12-24 | 1998-12-22 | Composition with high efficiency skin protection from damaging effects of ultraviolet light |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1047392A4 (en) |
| JP (2) | JP4150501B2 (en) |
| AU (1) | AU1944599A (en) |
| CA (1) | CA2318345C (en) |
| WO (1) | WO1999033439A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9803936A (en) * | 1998-09-08 | 2000-04-04 | Cosmeticos Natural Ind Com | Process and composition to increase the action of vitamin A on an individual's cellular activity and use of vitamin C. |
| BRPI0003166B1 (en) * | 1999-07-16 | 2015-08-25 | Natura Cosmeticos Sa | Process for stabilizing antioxidant compounds, and aqueous compositions |
| BR9902972B1 (en) * | 1999-07-16 | 2012-02-22 | biphasic composition for cosmetic or pharmaceutical use. | |
| ES2161161B1 (en) * | 1999-08-30 | 2002-07-01 | Consejo Superior Investigacion | Solid grape extract for protection against the sun consists of a residues based material containing gallic acid flavonol and e.g. procyanidine |
| GB9921238D0 (en) * | 1999-09-09 | 1999-11-10 | Boots Co Plc | Skincare composition |
| US6358517B1 (en) * | 1999-10-22 | 2002-03-19 | Unilever Home & Personal Care Usa, Division Of Conopco | Cosmetic compositions containing resveratrol and retinoids |
| CN1111068C (en) * | 2000-07-27 | 2003-06-11 | 上海北医大生物科技有限公司 | Strong anti-oxidative composite capsule of grape seed extract OPC and its producing method |
| FR2812192B1 (en) * | 2000-07-28 | 2003-01-31 | Oreal | USE OF PROSTAGLANDIN EP-3 RECEPTOR ANTAGONISTS AS A COSMETIC AGENT FOR MITIGATING, REDUCING OR STOPPING HAIR AND HAIR LOSS |
| FR2812190B1 (en) * | 2000-07-28 | 2003-01-31 | Oreal | USE OF NON-PROSTANOIC AGONISTS OF EP-2 AND / OR EP-4 PROSTAGLANDIN RECEPTORS AS A COSMETIC AGENT FOR MITIGATING, DECREASING OR STOPPING HAIR AND HAIR LOSS |
| JP2002204687A (en) * | 2000-11-09 | 2002-07-23 | Onaka Yasushi | APPLICATION OF beta-1,3-1,6-GLUCAN (AUREOBASIDIUM CULTURE SOLUTION) IN VARIOUS INDUSTRIAL FIELDS INCLUDING MEDICAL, HEALTH WELFARE AND FOOD INDUSTRIES |
| JP4824181B2 (en) * | 2001-02-13 | 2011-11-30 | 日本メナード化粧品株式会社 | Topical skin preparation |
| US6436378B1 (en) * | 2001-02-28 | 2002-08-20 | Colgate-Palmolive Company | Composition |
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|---|---|---|---|---|
| US5158772A (en) * | 1991-09-23 | 1992-10-27 | Davis Walter B | Unique bacterial polysaccharide polymer gel in cosmetics, pharmaceuticals and foods |
| US5279817A (en) * | 1992-10-02 | 1994-01-18 | Ricardo Franco | Suntanning oil formulation containing annatto |
| JP3770922B2 (en) * | 1993-05-28 | 2006-04-26 | 株式会社コーセー | Topical skin preparation |
| GB9403153D0 (en) * | 1994-02-18 | 1994-04-06 | Ciba Geigy Ag | Cosmetic compositions |
| US5505935A (en) * | 1994-05-09 | 1996-04-09 | Elizabeth Arden Company, Division Of Conopco, Inc. | Sunscreen compositions |
| US5486352A (en) * | 1995-01-03 | 1996-01-23 | Elizabeth Arden Company | Sunscreen compositions |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| US5609854A (en) * | 1995-06-06 | 1997-03-11 | Elizabeth Arden Company, Division Of Conopco, Inc. | Thickened and stabilized cosmetic emulsion compositions |
| WO1997039632A1 (en) * | 1996-04-22 | 1997-10-30 | Henkel Corporation | Natural antioxidant composition |
-
1998
- 1998-12-22 EP EP98964275A patent/EP1047392A4/en not_active Withdrawn
- 1998-12-22 AU AU19445/99A patent/AU1944599A/en not_active Abandoned
- 1998-12-22 CA CA2318345A patent/CA2318345C/en not_active Expired - Lifetime
- 1998-12-22 JP JP2000526199A patent/JP4150501B2/en not_active Expired - Lifetime
- 1998-12-22 WO PCT/US1998/027433 patent/WO1999033439A1/en active Application Filing
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2007
- 2007-12-25 JP JP2007332328A patent/JP2008088188A/en active Pending
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|---|---|
| JP2008088188A (en) | 2008-04-17 |
| CA2318345C (en) | 2011-06-07 |
| WO1999033439A1 (en) | 1999-07-08 |
| JP4150501B2 (en) | 2008-09-17 |
| EP1047392A4 (en) | 2004-10-06 |
| JP2001527032A (en) | 2001-12-25 |
| EP1047392A1 (en) | 2000-11-02 |
| AU1944599A (en) | 1999-07-19 |
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