CA2314872C - Method using a new calibrator and a device and test kit including the calibrator - Google Patents
Method using a new calibrator and a device and test kit including the calibrator Download PDFInfo
- Publication number
- CA2314872C CA2314872C CA002314872A CA2314872A CA2314872C CA 2314872 C CA2314872 C CA 2314872C CA 002314872 A CA002314872 A CA 002314872A CA 2314872 A CA2314872 A CA 2314872A CA 2314872 C CA2314872 C CA 2314872C
- Authority
- CA
- Canada
- Prior art keywords
- calibrator
- reactant
- analyte
- zone
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 89
- 238000012360 testing method Methods 0.000 title claims abstract description 30
- 239000000376 reactant Substances 0.000 claims abstract description 232
- 239000012491 analyte Substances 0.000 claims abstract description 113
- 239000011159 matrix material Substances 0.000 claims abstract description 104
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
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- 102000057297 Pepsin A Human genes 0.000 description 1
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- 125000003172 aldehyde group Chemical group 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
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- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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- 229910052737 gold Inorganic materials 0.000 description 1
- REKHIPAOQFESGJ-UHFFFAOYSA-N hydroxy(sulfo)carbamic acid Chemical compound C(=O)(O)N(S(O)(=O)=O)O REKHIPAOQFESGJ-UHFFFAOYSA-N 0.000 description 1
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- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Test And Diagnosis Of Digital Computers (AREA)
- Debugging And Monitoring (AREA)
- Techniques For Improving Reliability Of Storages (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704933A SE9704933D0 (sv) | 1997-12-30 | 1997-12-30 | Metod som utnyttjar en ny kalibrator och test kit som innehåller kalibratorn |
| SE9704933-2 | 1997-12-30 | ||
| PCT/SE1998/002464 WO1999036777A1 (en) | 1997-12-30 | 1998-12-30 | Method using a new calibrator and a device and test kit including the calibrator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2314872A1 CA2314872A1 (en) | 1999-07-22 |
| CA2314872C true CA2314872C (en) | 2009-04-14 |
Family
ID=20409627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002314872A Expired - Lifetime CA2314872C (en) | 1997-12-30 | 1998-12-30 | Method using a new calibrator and a device and test kit including the calibrator |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6916666B1 (https=) |
| EP (1) | EP1044373B1 (https=) |
| JP (1) | JP4331895B2 (https=) |
| AT (1) | ATE249626T1 (https=) |
| AU (1) | AU748059B2 (https=) |
| CA (1) | CA2314872C (https=) |
| DE (1) | DE69818104T2 (https=) |
| DK (1) | DK1044373T3 (https=) |
| ES (1) | ES2207868T3 (https=) |
| PT (1) | PT1044373E (https=) |
| SE (1) | SE9704933D0 (https=) |
| WO (1) | WO1999036777A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60238699D1 (de) * | 2001-09-17 | 2011-02-03 | Phadia Ab | Mehrfachanalytassay-vorrichtung mit multi-spot-nachweiszone |
| BR0215327A (pt) * | 2001-12-24 | 2006-06-06 | Kimberly Clark Co | sistema de calibração interna para ensaios de circulação de fluxo |
| US20030119203A1 (en) * | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| US6837171B1 (en) | 2002-04-29 | 2005-01-04 | Palmer/Snyder Furniture Company | Lightweight table with unitized table top |
| US7285424B2 (en) * | 2002-08-27 | 2007-10-23 | Kimberly-Clark Worldwide, Inc. | Membrane-based assay devices |
| US7314763B2 (en) | 2002-08-27 | 2008-01-01 | Kimberly-Clark Worldwide, Inc. | Fluidics-based assay devices |
| US7432105B2 (en) | 2002-08-27 | 2008-10-07 | Kimberly-Clark Worldwide, Inc. | Self-calibration system for a magnetic binding assay |
| US20040092036A1 (en) * | 2002-09-11 | 2004-05-13 | Lattec I/S | Device for analysing analyte compounds and use hereof |
| US7781172B2 (en) | 2003-11-21 | 2010-08-24 | Kimberly-Clark Worldwide, Inc. | Method for extending the dynamic detection range of assay devices |
| US20040121334A1 (en) * | 2002-12-19 | 2004-06-24 | Kimberly-Clark Worldwide, Inc. | Self-calibrated flow-through assay devices |
| US7247500B2 (en) | 2002-12-19 | 2007-07-24 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in membrane-based assay devices |
| US7851209B2 (en) | 2003-04-03 | 2010-12-14 | Kimberly-Clark Worldwide, Inc. | Reduction of the hook effect in assay devices |
| US20040197819A1 (en) | 2003-04-03 | 2004-10-07 | Kimberly-Clark Worldwide, Inc. | Assay devices that utilize hollow particles |
| US8101429B2 (en) | 2003-06-03 | 2012-01-24 | Siemens Healthcare Diagnostics Inc. | Native analyte as a reference in lateral flow assays |
| EP1646862B1 (en) * | 2003-06-03 | 2018-04-11 | Siemens Healthcare Diagnostics Inc. | Automatic identification of reagent test strips using reflectance values |
| WO2005031355A1 (en) | 2003-09-22 | 2005-04-07 | Quidel Corporation | Devices for the detection of multiple analytes in a sample |
| US7943395B2 (en) | 2003-11-21 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Extension of the dynamic detection range of assay devices |
| US7713748B2 (en) | 2003-11-21 | 2010-05-11 | Kimberly-Clark Worldwide, Inc. | Method of reducing the sensitivity of assay devices |
| US20050112703A1 (en) | 2003-11-21 | 2005-05-26 | Kimberly-Clark Worldwide, Inc. | Membrane-based lateral flow assay devices that utilize phosphorescent detection |
| ATE449337T1 (de) * | 2003-12-12 | 2009-12-15 | Inverness Medical Switzerland | Assay |
| US7943089B2 (en) | 2003-12-19 | 2011-05-17 | Kimberly-Clark Worldwide, Inc. | Laminated assay devices |
| US7521226B2 (en) | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
| US7906276B2 (en) | 2004-06-30 | 2011-03-15 | Kimberly-Clark Worldwide, Inc. | Enzymatic detection techniques |
| CA2475456A1 (en) | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to optimize analyte and antibody substrate binding by least energy adsorption |
| CA2475240A1 (en) * | 2004-07-20 | 2006-01-20 | Biophys, Inc. | Method and device to measure dynamic internal calibration true dose response curves |
| US8101415B2 (en) * | 2005-07-05 | 2012-01-24 | Bayer Healthcare Llc | Calibration system for use with lateral flow assay test strips |
| WO2007149043A1 (en) * | 2006-06-20 | 2007-12-27 | Åmic AB | Assay device |
| CA2647953A1 (en) * | 2008-12-29 | 2010-06-29 | Sqi Diagnostics Systems Inc. | Multiplex analyte detection |
| DE102009010563A1 (de) | 2009-02-16 | 2010-08-26 | Matthias W. Engel | Vorrichtung zum Nachweis von Analyten in Körperflüssigkeiten |
| DE102009037791A1 (de) * | 2009-08-17 | 2011-02-24 | Dst Diagnostische Systeme & Technologien Gmbh | Testsystem zur visuellen Auswertung |
| US20120214230A1 (en) * | 2009-10-22 | 2012-08-23 | Ge Healthcare Bio-Sciences Ab | Cell culture/handling product and method for production and use thereof |
| US8486717B2 (en) | 2011-01-18 | 2013-07-16 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| AU2012309203B2 (en) * | 2011-09-14 | 2017-08-10 | Phadia Ab | Calibration reagent and method |
| US9874556B2 (en) | 2012-07-18 | 2018-01-23 | Symbolics, Llc | Lateral flow assays using two dimensional features |
| US20140072959A1 (en) | 2012-09-12 | 2014-03-13 | Force Diagnostics, Inc. | Rapid tests for insurance underwriting |
| CN105102980B (zh) | 2013-02-26 | 2017-11-03 | 阿斯图特医药公司 | 具有试条保持件的横向流动测定法 |
| CN108051590B (zh) | 2013-09-13 | 2020-12-11 | Symbolics有限责任公司 | 运用二维试验和对照信号读出模式的侧向层析检测 |
| BR112017021305A2 (pt) | 2015-04-06 | 2018-06-26 | Bludiagnostics Inc | dispositivo de teste de fluxo lateral, e, método e kit para detecção quantitativa de um analito em uma amostra de saliva |
| WO2018039047A1 (en) | 2016-08-23 | 2018-03-01 | Qoolabs, Inc. | Lateral flow assay for assessing recombinant protein expression or reporter gene expression |
| KR102582297B1 (ko) | 2017-05-19 | 2023-09-25 | 필립모리스 프로덕츠 에스.에이. | 대상체의 흡연 상태를 구별하기 위한 진단 테스트 |
| EP3910335A1 (en) * | 2020-05-11 | 2021-11-17 | Koninklijke Philips N.V. | Calibration using a regenerative surface |
| US20220268765A1 (en) * | 2021-02-22 | 2022-08-25 | Waters Technologies Corporation | Methods and kits for universal calibration of lateral flow testing |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4446231A (en) * | 1979-10-03 | 1984-05-01 | Self Colin H | Immunoassay using an amplified cyclic detection system |
| JPS59170768A (ja) | 1983-03-17 | 1984-09-27 | Fuji Photo Film Co Ltd | 非アイソト−プアツセイ用多層分析要素およびそれを用いるアツセイ方法 |
| DE3445816C1 (de) | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| US4740468A (en) * | 1985-02-14 | 1988-04-26 | Syntex (U.S.A.) Inc. | Concentrating immunochemical test device and method |
| CA1272127A (en) | 1985-04-04 | 1990-07-31 | Hybritech Incorporated | Solid phase system for use in ligand-receptor assays |
| JPS62231168A (ja) * | 1986-03-21 | 1987-10-09 | ハイブリテツク・インコ−ポレイテツド | アナライト−レセプタ−分析用内部標準を設けるための改良法 |
| JPS63253464A (ja) | 1987-04-10 | 1988-10-20 | Hitachi Ltd | 計画作成支援システム |
| US5132097A (en) * | 1987-02-11 | 1992-07-21 | G.D. Research | Apparatus for analysis of specific binding complexes |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| DE3856421T2 (de) | 1987-04-27 | 2000-12-14 | Unilever Nv | Spezifische Bindungstestverfahren |
| US5120643A (en) | 1987-07-13 | 1992-06-09 | Abbott Laboratories | Process for immunochromatography with colloidal particles |
| US6352862B1 (en) * | 1989-02-17 | 2002-03-05 | Unilever Patent Holdings B.V. | Analytical test device for imuno assays and methods of using same |
| CA2003942A1 (en) | 1989-09-26 | 1991-03-26 | Julie Lia Rudolph | Solid assay support systems |
| ES2092523T3 (es) | 1990-05-09 | 1996-12-01 | Abbott Lab | Ensayos que utilizan enlaces con recuperacion de conjugado. |
| FR2665087B1 (fr) | 1990-07-24 | 1992-10-09 | Lorraine Carbone | Procede de fabrication d'une membrane minerale ultra-mince et asymetrique. |
| US6027944A (en) * | 1990-11-22 | 2000-02-22 | Applied Research Systems Ars Holding Nv | Capillary-fill biosensor device comprising a calibration zone |
| US5726064A (en) | 1990-11-22 | 1998-03-10 | Applied Research Systems Ars Holding Nv | Method of assay having calibration within the assay |
| GB9025471D0 (en) * | 1990-11-22 | 1991-01-09 | Ares Serono Res & Dev Ltd | Method of assay |
| US5314804A (en) * | 1992-03-24 | 1994-05-24 | Serim Research Corporation | Test for Helicobacter pylori |
| US5356782A (en) | 1992-09-03 | 1994-10-18 | Boehringer Mannheim Corporation | Analytical test apparatus with on board negative and positive control |
| GB9325718D0 (en) * | 1993-12-16 | 1994-02-16 | Ars Holding 89 Nv | Sensor device for sandwich assay |
| SE9500184D0 (sv) | 1995-01-20 | 1995-01-20 | Pharmacia Ab | Analysmetod som utnyttjar biospecifika affinitetsreaktioner och märkt reaktant samt reagens att användas i föredragen utförandeform |
| AUPN527995A0 (en) * | 1995-09-07 | 1995-09-28 | Agen Biomedical Limited | Method and apparatus for semiquantification of an analyte |
| US6015662A (en) | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
-
1997
- 1997-12-30 SE SE9704933A patent/SE9704933D0/xx unknown
-
1998
- 1998-12-30 WO PCT/SE1998/002464 patent/WO1999036777A1/en not_active Ceased
- 1998-12-30 DE DE69818104T patent/DE69818104T2/de not_active Expired - Lifetime
- 1998-12-30 AT AT98965943T patent/ATE249626T1/de active
- 1998-12-30 AU AU21950/99A patent/AU748059B2/en not_active Expired
- 1998-12-30 PT PT98965943T patent/PT1044373E/pt unknown
- 1998-12-30 DK DK98965943T patent/DK1044373T3/da active
- 1998-12-30 EP EP98965943A patent/EP1044373B1/en not_active Expired - Lifetime
- 1998-12-30 CA CA002314872A patent/CA2314872C/en not_active Expired - Lifetime
- 1998-12-30 JP JP2000540438A patent/JP4331895B2/ja not_active Expired - Lifetime
- 1998-12-30 US US09/582,741 patent/US6916666B1/en not_active Expired - Lifetime
- 1998-12-30 ES ES98965943T patent/ES2207868T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU748059B2 (en) | 2002-05-30 |
| SE9704933D0 (sv) | 1997-12-30 |
| AU2195099A (en) | 1999-08-02 |
| DE69818104D1 (de) | 2003-10-16 |
| CA2314872A1 (en) | 1999-07-22 |
| ATE249626T1 (de) | 2003-09-15 |
| US6916666B1 (en) | 2005-07-12 |
| PT1044373E (pt) | 2003-12-31 |
| EP1044373B1 (en) | 2003-09-10 |
| DE69818104T2 (de) | 2004-07-15 |
| JP2002509252A (ja) | 2002-03-26 |
| WO1999036777A1 (en) | 1999-07-22 |
| EP1044373A1 (en) | 2000-10-18 |
| ES2207868T3 (es) | 2004-06-01 |
| JP4331895B2 (ja) | 2009-09-16 |
| DK1044373T3 (da) | 2004-01-12 |
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