CA2311311C - Biodegradable intra vaginal devices - Google Patents
Biodegradable intra vaginal devices Download PDFInfo
- Publication number
- CA2311311C CA2311311C CA002311311A CA2311311A CA2311311C CA 2311311 C CA2311311 C CA 2311311C CA 002311311 A CA002311311 A CA 002311311A CA 2311311 A CA2311311 A CA 2311311A CA 2311311 C CA2311311 C CA 2311311C
- Authority
- CA
- Canada
- Prior art keywords
- insert
- mass
- progesterone
- caprolactone
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract description 108
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims abstract description 58
- 229960003387 progesterone Drugs 0.000 claims abstract description 54
- 239000000186 progesterone Substances 0.000 claims abstract description 54
- 150000004676 glycans Chemical class 0.000 claims abstract description 19
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 19
- 239000005017 polysaccharide Substances 0.000 claims abstract description 19
- 238000003780 insertion Methods 0.000 claims abstract description 18
- 230000037431 insertion Effects 0.000 claims abstract description 18
- 230000014759 maintenance of location Effects 0.000 claims abstract description 18
- 241000124008 Mammalia Species 0.000 claims abstract description 15
- 239000008177 pharmaceutical agent Substances 0.000 claims abstract description 12
- 239000011159 matrix material Substances 0.000 claims abstract description 11
- 239000013543 active substance Substances 0.000 claims abstract description 8
- 239000004621 biodegradable polymer Substances 0.000 claims abstract description 6
- 229920002988 biodegradable polymer Polymers 0.000 claims abstract description 6
- 229920000858 Cyclodextrin Polymers 0.000 claims description 20
- 241001465754 Metazoa Species 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 11
- 210000001215 vagina Anatomy 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- 210000002966 serum Anatomy 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000015556 catabolic process Effects 0.000 claims description 5
- 238000006731 degradation reaction Methods 0.000 claims description 5
- 238000000338 in vitro Methods 0.000 claims description 5
- 241000894007 species Species 0.000 claims description 5
- 241000283707 Capra Species 0.000 claims description 3
- 241000282994 Cervidae Species 0.000 claims description 3
- 241000283086 Equidae Species 0.000 claims description 3
- 241001494479 Pecora Species 0.000 claims description 3
- 241000282887 Suidae Species 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000002269 spontaneous effect Effects 0.000 claims description 3
- 230000012173 estrus Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 20
- 229920001296 polysiloxane Polymers 0.000 description 11
- 239000002361 compost Substances 0.000 description 9
- -1 poly(e-caprolactone) Polymers 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 238000001746 injection moulding Methods 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000012858 resilient material Substances 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 229950008885 polyglycolic acid Drugs 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ329229 | 1997-11-21 | ||
| NZ32922997A NZ329229A (en) | 1997-11-21 | 1997-11-21 | Biodegradable intravaginal devices |
| NZ33059598 | 1998-06-05 | ||
| NZ330595 | 1998-06-05 | ||
| NZ330596A NZ330596A (en) | 1998-06-05 | 1998-06-05 | Intravaginal devices allowing for increased uptake of active ingredients |
| NZ330596 | 1998-06-05 | ||
| PCT/NZ1998/000169 WO1999026556A1 (en) | 1997-11-21 | 1998-11-23 | Biodegradable intra vaginal devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2311311A1 CA2311311A1 (en) | 1999-06-03 |
| CA2311311C true CA2311311C (en) | 2008-05-06 |
Family
ID=27353841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002311311A Expired - Fee Related CA2311311C (en) | 1997-11-21 | 1998-11-23 | Biodegradable intra vaginal devices |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1039843A4 (enExample) |
| JP (1) | JP2001523515A (enExample) |
| AU (1) | AU758858B2 (enExample) |
| CA (1) | CA2311311C (enExample) |
| WO (1) | WO1999026556A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ330596A (en) * | 1998-06-05 | 2001-02-23 | Dec Res | Intravaginal devices allowing for increased uptake of active ingredients |
| NZ337318A (en) | 1999-08-18 | 2002-07-26 | Interag | Dispensing apparatus for dispensing same or different materials for at least two reservoirs |
| GB0009914D0 (en) | 2000-04-20 | 2000-06-07 | Metris Therapeutics Limited | Device |
| ATE455526T1 (de) * | 2000-08-24 | 2010-02-15 | Sidney Lerner | Nicht-hormonales vaginales verhütungsmittel |
| US20020106406A1 (en) * | 2000-12-08 | 2002-08-08 | Mchugh Anthony J. | Crystallizable/non-crystallizable polymer composites |
| NZ514279A (en) * | 2001-09-20 | 2004-02-27 | Ashmont Holdings Ltd | Intraruminal device for dispensing medication where device has arms that open to keep the device in the animal's rumen after a constraint device dissolves |
| US20060052341A1 (en) * | 2002-02-08 | 2006-03-09 | Brian Cornish | Control of a biological function |
| WO2004091570A1 (en) * | 2003-04-17 | 2004-10-28 | Interag | Method of treatment |
| JP2023508606A (ja) * | 2019-12-23 | 2023-03-02 | オーガスタ ユニバーシティ リサーチ インスティチュート，インコーポレイテッド | 排卵を誘発し、黄体期支持を提供するプロゲステロン製剤 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732763A (en) * | 1978-10-17 | 1988-03-22 | Stolle Research And Development Corporation | Active/passive immunization of the internal female reproductive organs |
| US5116619A (en) * | 1988-08-30 | 1992-05-26 | Lee Roy Morgan | Vaginal progesterone tablet |
| US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| NZ228382A (en) * | 1989-03-17 | 1992-08-26 | Carter Holt Harvey Plastic Pro | Drug administering coil-like device for insertion in body cavity of animal |
| US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| GB9605857D0 (en) * | 1996-03-20 | 1996-05-22 | Tester Richard F | Polysaccharides as chemical release systems |
| NZ286492A (en) | 1996-05-01 | 1998-02-26 | Dec International Nz Ltd Subst | Intra vaginal devices for synchronising oestrus of animals is made up of cured silicone rubber material with 5% by weight of progesterone |
| KR100583275B1 (ko) * | 1997-05-28 | 2006-05-24 | 인터랙 | 돼지용 질내 삽입기구 |
-
1998
- 1998-11-23 EP EP98961699A patent/EP1039843A4/en not_active Withdrawn
- 1998-11-23 CA CA002311311A patent/CA2311311C/en not_active Expired - Fee Related
- 1998-11-23 AU AU16962/99A patent/AU758858B2/en not_active Ceased
- 1998-11-23 JP JP2000521763A patent/JP2001523515A/ja active Pending
- 1998-11-23 WO PCT/NZ1998/000169 patent/WO1999026556A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1039843A4 (en) | 2007-12-26 |
| WO1999026556A1 (en) | 1999-06-03 |
| JP2001523515A (ja) | 2001-11-27 |
| AU1696299A (en) | 1999-06-15 |
| CA2311311A1 (en) | 1999-06-03 |
| EP1039843A1 (en) | 2000-10-04 |
| AU758858B2 (en) | 2003-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |