CA2309761A1 - Appauvrissement de la cellule th2, compositions et methodes en rapport - Google Patents
Appauvrissement de la cellule th2, compositions et methodes en rapport Download PDFInfo
- Publication number
- CA2309761A1 CA2309761A1 CA002309761A CA2309761A CA2309761A1 CA 2309761 A1 CA2309761 A1 CA 2309761A1 CA 002309761 A CA002309761 A CA 002309761A CA 2309761 A CA2309761 A CA 2309761A CA 2309761 A1 CA2309761 A1 CA 2309761A1
- Authority
- CA
- Canada
- Prior art keywords
- ccr8
- cells
- binding
- antagonist
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Cette invention, qui a trait à des compositions de liaison se liant de manière sélective à un marqueur présent de manière spécifique sur des cellules Th2, concerne également diverses méthodes d'utilisation de ces compositions. La méthode fait, notamment, usage du fait que le récepteur de chémokine CCR8 est exprimé de manière sélective dans le sous-ensemble de cellule Th2. La composition de liaison est, de préférence, un anticorps monoclonal spécifique de CCR8.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6539297P | 1997-11-13 | 1997-11-13 | |
US60/065,392 | 1997-11-13 | ||
PCT/US1998/023240 WO1999025734A2 (fr) | 1997-11-13 | 1998-11-12 | APPAUVRISSEMENT DE LA CELLULE Th2, COMPOSITIONS ET METHODES EN RAPPORT |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2309761A1 true CA2309761A1 (fr) | 1999-05-27 |
Family
ID=22062409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002309761A Abandoned CA2309761A1 (fr) | 1997-11-13 | 1998-11-12 | Appauvrissement de la cellule th2, compositions et methodes en rapport |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1030865A2 (fr) |
JP (1) | JP2001523446A (fr) |
AR (1) | AR016681A1 (fr) |
AU (1) | AU1373099A (fr) |
CA (1) | CA2309761A1 (fr) |
WO (1) | WO1999025734A2 (fr) |
ZA (1) | ZA9810371B (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6416954B1 (en) * | 1999-02-08 | 2002-07-09 | Schering Corporation | Modulating Th2 cell levels via vMIP-I/CCR8 interaction |
WO2001058484A2 (fr) * | 2000-02-10 | 2001-08-16 | Schering Corporation | Nouvelles utilisations des recepteurs ccr8 de mammiferes et reactifs associes |
US6762341B2 (en) | 2000-02-10 | 2004-07-13 | Schering Corporation | Uses of mammalian CCR8 receptors and related reagents |
AU2003229753A1 (en) * | 2002-05-13 | 2003-11-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with chemokine receptor 8 (ccr8) |
WO2007044756A2 (fr) * | 2005-10-11 | 2007-04-19 | Icos Corporation | Anticorps monoclonaux reconnaissant le ccr8 humain |
WO2014082993A2 (fr) * | 2012-11-30 | 2014-06-05 | Galapagos Nv | Cibles moléculaires et composés, et procédés d'identification de ceux-ci, utiles dans la régulation à la baisse de la réponse th2 |
JP7358047B2 (ja) * | 2016-05-16 | 2023-10-10 | チェックマブ エス.アール.エル. | 腫瘍浸潤制御性t細胞において選択的に脱制御されたマーカー |
CA3124332A1 (fr) * | 2018-12-27 | 2020-07-02 | Shionogi & Co., Ltd. | Nouvel anticorps anti-ccr8 |
MX2022009947A (es) | 2020-02-14 | 2022-11-07 | Jounce Therapeutics Inc | Anticuerpos y proteinas de fusion que se unen a ccr8 y usos de estos. |
WO2023219147A1 (fr) * | 2022-05-13 | 2023-11-16 | 塩野義製薬株式会社 | Nouveaux anticorps anti-ccr8 pour la détection de ccr8 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4364932A (en) * | 1979-09-18 | 1982-12-21 | Ortho Pharmaceutical Corporation | Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same |
EP0843557B1 (fr) * | 1995-07-21 | 2002-11-13 | Applied Research Systems ARS Holding N.V. | Procedes pour detecter, identifier, isoler, marquer et cibler selectivement les lymphocytes th1, au moyen de la proteine lag-3 |
US6040426A (en) * | 1996-06-05 | 2000-03-21 | Bml, Inc. | Human Th2 specific protein |
-
1998
- 1998-11-12 WO PCT/US1998/023240 patent/WO1999025734A2/fr not_active Application Discontinuation
- 1998-11-12 CA CA002309761A patent/CA2309761A1/fr not_active Abandoned
- 1998-11-12 EP EP98957483A patent/EP1030865A2/fr not_active Withdrawn
- 1998-11-12 AR ARP980105731A patent/AR016681A1/es unknown
- 1998-11-12 JP JP2000521113A patent/JP2001523446A/ja active Pending
- 1998-11-12 ZA ZA9810371A patent/ZA9810371B/xx unknown
- 1998-11-12 AU AU13730/99A patent/AU1373099A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1030865A2 (fr) | 2000-08-30 |
AU1373099A (en) | 1999-06-07 |
WO1999025734A2 (fr) | 1999-05-27 |
JP2001523446A (ja) | 2001-11-27 |
ZA9810371B (en) | 1999-08-30 |
AR016681A1 (es) | 2001-07-25 |
WO1999025734A3 (fr) | 1999-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |