CA2309383A1 - Genes a expression reduite dans les neurones mesencephaliques dopaminergiques - Google Patents

Genes a expression reduite dans les neurones mesencephaliques dopaminergiques Download PDF

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Publication number
CA2309383A1
CA2309383A1 CA002309383A CA2309383A CA2309383A1 CA 2309383 A1 CA2309383 A1 CA 2309383A1 CA 002309383 A CA002309383 A CA 002309383A CA 2309383 A CA2309383 A CA 2309383A CA 2309383 A1 CA2309383 A1 CA 2309383A1
Authority
CA
Canada
Prior art keywords
nucleic acid
gene
ptx3
expression
neurological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002309383A
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English (en)
Inventor
Johannes Peter Henri Burbach
Marten Piet Smidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rijksuniversiteit Utrecht
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2309383A1 publication Critical patent/CA2309383A1/fr
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention se rapporte aux domaines neurologique, psychiatrique, neuropathologique et neuropharmacologique, et tout particulièrement aux troubles neurologiques et psychiatriques tels que la maladie de Parkinson et la dyskinésie tardive, et aux troubles psychiatriques tels que la schizophrénie, la toxicomanie et les troubles affectifs, du type maladie affective bipolaire, et autres troubles associés au dysfonctionnement du système mésencéphalique dopaminergique (mesDA). L'invention se rapporte à un acide nucléique isolé et/ou recombiné ou à un fragment spécifique, homologue ou dérivé de cet acide nucléique, correspondant à un gène ayant une expression réduite dans les neurones mésencéphaliques dopaminergiques. Le gène en question est lié aux troubles neurologiques et psychiatriques du type maladie de Parkinson, dyskinésie tardive, maladie affective bipolaire et schizophrénie.
CA002309383A 1997-11-11 1998-11-11 Genes a expression reduite dans les neurones mesencephaliques dopaminergiques Abandoned CA2309383A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97203511.7 1997-11-11
EP97203511 1997-11-11
PCT/NL1998/000652 WO1999024572A1 (fr) 1997-11-11 1998-11-11 Genes a expression reduite dans les neurones mesencephaliques dopaminergiques

Publications (1)

Publication Number Publication Date
CA2309383A1 true CA2309383A1 (fr) 1999-05-20

Family

ID=8228917

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309383A Abandoned CA2309383A1 (fr) 1997-11-11 1998-11-11 Genes a expression reduite dans les neurones mesencephaliques dopaminergiques

Country Status (4)

Country Link
EP (1) EP1029051A1 (fr)
AU (1) AU1179699A (fr)
CA (1) CA2309383A1 (fr)
WO (1) WO1999024572A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007047699A1 (fr) * 2005-10-17 2007-04-26 Epigenomics Ag Méthode et acides nucléiques pour le traitement amélioré de cancers du sein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor

Also Published As

Publication number Publication date
EP1029051A1 (fr) 2000-08-23
AU1179699A (en) 1999-05-31
WO1999024572A1 (fr) 1999-05-20

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Legal Events

Date Code Title Description
FZDE Discontinued