CA2309347A1 - Inhibiteurs de thrombine - Google Patents

Inhibiteurs de thrombine Download PDF

Info

Publication number
CA2309347A1
CA2309347A1 CA002309347A CA2309347A CA2309347A1 CA 2309347 A1 CA2309347 A1 CA 2309347A1 CA 002309347 A CA002309347 A CA 002309347A CA 2309347 A CA2309347 A CA 2309347A CA 2309347 A1 CA2309347 A1 CA 2309347A1
Authority
CA
Canada
Prior art keywords
mammal
blood
pharmaceutically acceptable
compound
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002309347A
Other languages
English (en)
Inventor
Craig Coburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9809784.3A external-priority patent/GB9809784D0/en
Application filed by Individual filed Critical Individual
Publication of CA2309347A1 publication Critical patent/CA2309347A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne un composé qui inhibe la thrombine humaine et qui possède la structure (I), tel que (II).
CA002309347A 1997-12-01 1998-11-25 Inhibiteurs de thrombine Abandoned CA2309347A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6709697P 1997-12-01 1997-12-01
US60/067,096 1997-12-01
GB9809784.3 1998-05-07
GBGB9809784.3A GB9809784D0 (en) 1998-05-07 1998-05-07 Thrombin Inhibitors
PCT/US1998/025362 WO1999027930A1 (fr) 1997-12-01 1998-11-25 Inhibiteurs de thrombine

Publications (1)

Publication Number Publication Date
CA2309347A1 true CA2309347A1 (fr) 1999-06-10

Family

ID=26313616

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309347A Abandoned CA2309347A1 (fr) 1997-12-01 1998-11-25 Inhibiteurs de thrombine

Country Status (5)

Country Link
EP (1) EP1039907A4 (fr)
JP (1) JP2001524522A (fr)
AU (1) AU741766B2 (fr)
CA (1) CA2309347A1 (fr)
WO (1) WO1999027930A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU747776B2 (en) * 1998-10-30 2002-05-23 Merck & Co., Inc. Thrombin inhibitors
DE19900471A1 (de) * 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo[4,5c]-pyridin-4-on-derivate
JP7268049B2 (ja) 2018-03-08 2023-05-02 インサイト・コーポレイション ＰＩ３Ｋ－γ阻害剤としてのアミノピラジンジオール化合物
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5658930A (en) * 1994-12-13 1997-08-19 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
JPH11508558A (ja) * 1995-06-27 1999-07-27 メルク エンド カンパニー インコーポレーテッド ピリジノン トロンビン阻害剤
CA2245811A1 (fr) * 1996-02-22 1997-08-28 Merck & Co., Inc. Inhibiteurs de pyridinone thrombine

Also Published As

Publication number Publication date
AU741766B2 (en) 2001-12-06
JP2001524522A (ja) 2001-12-04
EP1039907A1 (fr) 2000-10-04
EP1039907A4 (fr) 2001-09-19
WO1999027930A1 (fr) 1999-06-10
AU1539599A (en) 1999-06-16

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Legal Events

Date Code Title Description
FZDE Dead