CA2307102A1 - Percutaneous myocardial revascularization growth factor mediums and method - Google Patents
Percutaneous myocardial revascularization growth factor mediums and method Download PDFInfo
- Publication number
- CA2307102A1 CA2307102A1 CA002307102A CA2307102A CA2307102A1 CA 2307102 A1 CA2307102 A1 CA 2307102A1 CA 002307102 A CA002307102 A CA 002307102A CA 2307102 A CA2307102 A CA 2307102A CA 2307102 A1 CA2307102 A1 CA 2307102A1
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- Prior art keywords
- myocardium
- recited
- blood perfusion
- heart chamber
- promoting
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- Abandoned
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
- A61M25/0084—Catheter tip comprising a tool being one or more injection needles
- A61M2025/0089—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6421097P | 1997-11-04 | 1997-11-04 | |
| US60/064,210 | 1997-11-04 | ||
| US09/184,220 US6045565A (en) | 1997-11-04 | 1998-11-02 | Percutaneous myocardial revascularization growth factor mediums and method |
| US09/184,220 | 1998-11-02 | ||
| PCT/US1998/023396 WO1999022655A1 (en) | 1997-11-04 | 1998-11-03 | Percutaneous myocardial revascularization growth factor mediums and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2307102A1 true CA2307102A1 (en) | 1999-05-14 |
Family
ID=26744273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002307102A Abandoned CA2307102A1 (en) | 1997-11-04 | 1998-11-03 | Percutaneous myocardial revascularization growth factor mediums and method |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6045565A (enExample) |
| EP (1) | EP1028661A4 (enExample) |
| JP (1) | JP4282898B2 (enExample) |
| CA (1) | CA2307102A1 (enExample) |
| DE (1) | DE1028661T1 (enExample) |
| WO (1) | WO1999022655A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2758024C1 (ru) * | 2021-03-05 | 2021-10-25 | Юрий Леонидович Шевченко | Способ индукции экстракардиальной реваскуляризации миокарда у больных ишемической болезнью сердца |
Families Citing this family (169)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6322548B1 (en) | 1995-05-10 | 2001-11-27 | Eclipse Surgical Technologies | Delivery catheter system for heart chamber |
| US6258083B1 (en) | 1996-03-29 | 2001-07-10 | Eclipse Surgical Technologies, Inc. | Viewing surgical scope for minimally invasive procedures |
| US6152918A (en) * | 1996-04-05 | 2000-11-28 | Eclipse Surgical Technologies, Inc. | Laser device with auto-piercing tip for myocardial revascularization procedures |
| US6443974B1 (en) | 1996-07-28 | 2002-09-03 | Biosense, Inc. | Electromagnetic cardiac biostimulation |
| US5755682A (en) | 1996-08-13 | 1998-05-26 | Heartstent Corporation | Method and apparatus for performing coronary artery bypass surgery |
| US6051008A (en) | 1996-12-02 | 2000-04-18 | Angiotrax, Inc. | Apparatus having stabilization members for percutaneously performing surgery and methods of use |
| US6102926A (en) | 1996-12-02 | 2000-08-15 | Angiotrax, Inc. | Apparatus for percutaneously performing myocardial revascularization having means for sensing tissue parameters and methods of use |
| US6120520A (en) | 1997-05-27 | 2000-09-19 | Angiotrax, Inc. | Apparatus and methods for stimulating revascularization and/or tissue growth |
| US6045565A (en) | 1997-11-04 | 2000-04-04 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization growth factor mediums and method |
| US6416510B1 (en) * | 1997-03-13 | 2002-07-09 | Biocardia, Inc. | Drug delivery catheters that attach to tissue and methods for their use |
| US5866561A (en) * | 1997-08-21 | 1999-02-02 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
| US6179809B1 (en) | 1997-09-24 | 2001-01-30 | Eclipse Surgical Technologies, Inc. | Drug delivery catheter with tip alignment |
| US5980548A (en) | 1997-10-29 | 1999-11-09 | Kensey Nash Corporation | Transmyocardial revascularization system |
| US6056743A (en) | 1997-11-04 | 2000-05-02 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization device and method |
| US6749617B1 (en) * | 1997-11-04 | 2004-06-15 | Scimed Life Systems, Inc. | Catheter and implants for the delivery of therapeutic agents to tissues |
| US6251418B1 (en) * | 1997-12-18 | 2001-06-26 | C.R. Bard, Inc. | Systems and methods for local delivery of an agent |
| DE69838526T2 (de) | 1998-02-05 | 2008-07-03 | Biosense Webster, Inc., Diamond Bar | Gerät zum Freisetzen eines Medikaments im Herzen |
| US8079982B1 (en) | 1998-06-04 | 2011-12-20 | Biosense Webster, Inc. | Injection catheter with needle electrode |
| US7416547B2 (en) | 1999-03-29 | 2008-08-26 | Biosense Webster Inc. | Injection catheter |
| CA2273467C (en) * | 1998-06-04 | 2009-02-17 | Cordis Webster, Inc. | Catheter for injecting therapeutic and diagnostic agents |
| US6623473B1 (en) | 1998-06-04 | 2003-09-23 | Biosense Webster, Inc. | Injection catheter with multi-directional delivery injection needle |
| US6540725B1 (en) | 1998-06-04 | 2003-04-01 | Biosense Webster, Inc. | Injection catheter with controllably extendable injection needle |
| US7252818B2 (en) * | 1998-07-24 | 2007-08-07 | Cardiovascular Biotherapeutics, Inc. | Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis |
| US6406488B1 (en) * | 1998-08-27 | 2002-06-18 | Heartstent Corporation | Healing transmyocardial implant |
| US6641610B2 (en) * | 1998-09-10 | 2003-11-04 | Percardia, Inc. | Valve designs for left ventricular conduits |
| US6254564B1 (en) | 1998-09-10 | 2001-07-03 | Percardia, Inc. | Left ventricular conduit with blood vessel graft |
| EP1112043B1 (en) | 1998-09-10 | 2006-04-05 | Percardia, Inc. | Tmr shunt |
| US6290728B1 (en) | 1998-09-10 | 2001-09-18 | Percardia, Inc. | Designs for left ventricular conduit |
| US6196230B1 (en) * | 1998-09-10 | 2001-03-06 | Percardia, Inc. | Stent delivery system and method of use |
| US6689121B1 (en) | 1998-09-24 | 2004-02-10 | C. R. Bard, Inc. | Systems and methods for treating ischemia |
| US6432126B1 (en) * | 1998-09-30 | 2002-08-13 | C.R. Bard, Inc. | Flexible vascular inducing implants |
| US6251079B1 (en) | 1998-09-30 | 2001-06-26 | C. R. Bard, Inc. | Transthoracic drug delivery device |
| US6458092B1 (en) | 1998-09-30 | 2002-10-01 | C. R. Bard, Inc. | Vascular inducing implants |
| US6248112B1 (en) | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
| US6692520B1 (en) | 1998-12-15 | 2004-02-17 | C. R. Bard, Inc. | Systems and methods for imbedded intramuscular implants |
| US6620170B1 (en) | 1999-04-26 | 2003-09-16 | C. R. Bard, Inc. | Devices and methods for treating ischemia by creating a fibrin plug |
| US6409697B2 (en) | 1999-05-04 | 2002-06-25 | Heartstent Corporation | Transmyocardial implant with forward flow bias |
| US6986784B1 (en) | 1999-05-14 | 2006-01-17 | C. R. Bard, Inc. | Implant anchor systems |
| US6719805B1 (en) * | 1999-06-09 | 2004-04-13 | C. R. Bard, Inc. | Devices and methods for treating tissue |
| US6277082B1 (en) | 1999-07-22 | 2001-08-21 | C. R. Bard, Inc. | Ischemia detection system |
| US6629987B1 (en) * | 1999-07-30 | 2003-10-07 | C. R. Bard, Inc. | Catheter positioning systems |
| US6302892B1 (en) | 1999-08-04 | 2001-10-16 | Percardia, Inc. | Blood flow conduit delivery system and method of use |
| US6855160B1 (en) | 1999-08-04 | 2005-02-15 | C. R. Bard, Inc. | Implant and agent delivery device |
| US6638237B1 (en) * | 1999-08-04 | 2003-10-28 | Percardia, Inc. | Left ventricular conduits and methods for delivery |
| JP2003506143A (ja) * | 1999-08-04 | 2003-02-18 | シー・アール・バード・インク | インプラント及び薬剤供給装置 |
| US6253768B1 (en) | 1999-08-04 | 2001-07-03 | Percardia, Inc. | Vascular graft bypass |
| US7033372B1 (en) | 1999-08-04 | 2006-04-25 | Percardia, Inc. | Corkscrew reinforced left ventricle to coronary artery channel |
| AU6521500A (en) * | 1999-08-05 | 2001-03-05 | Cornell Research Foundation Inc. | Gene therapy platformed needle and method of administering therapeutic solution to a heart |
| US6709427B1 (en) * | 1999-08-05 | 2004-03-23 | Kensey Nash Corporation | Systems and methods for delivering agents into targeted tissue of a living being |
| US6551338B1 (en) | 1999-09-01 | 2003-04-22 | Mcgill University | Method and device for myogenesis and angiogenesis of the heart |
| US6605053B1 (en) | 1999-09-10 | 2003-08-12 | Percardia, Inc. | Conduit designs and related methods for optimal flow control |
| US8808272B2 (en) | 1999-10-28 | 2014-08-19 | Boston Scientific Scimed, Inc. | Biocompatible medical devices |
| US6663606B1 (en) | 1999-10-28 | 2003-12-16 | Scimed Life Systems, Inc. | Biocompatible medical devices |
| US6800073B2 (en) | 1999-10-28 | 2004-10-05 | Scimed Life Systems, Inc. | Biocompatible pharmaceutical articles |
| EP1099453B1 (en) * | 1999-11-12 | 2005-06-01 | Biosense Webster, Inc. | Injection catheter |
| US6854467B2 (en) | 2000-05-04 | 2005-02-15 | Percardia, Inc. | Methods and devices for delivering a ventricular stent |
| US7232421B1 (en) | 2000-05-12 | 2007-06-19 | C. R. Bard, Inc. | Agent delivery systems |
| US6613025B1 (en) * | 2000-05-25 | 2003-09-02 | Scimed Life Systems, Inc. | Method and apparatus for diagnostic and therapeutic agent delivery |
| AU2001273421A1 (en) * | 2000-07-13 | 2002-01-30 | Bioheart, Inc. | Deployment system for myocardial cellular material |
| US20020032478A1 (en) * | 2000-08-07 | 2002-03-14 | Percardia, Inc. | Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel |
| US6893421B1 (en) * | 2000-08-08 | 2005-05-17 | Scimed Life Systems, Inc. | Catheter shaft assembly |
| US6595958B1 (en) * | 2000-08-08 | 2003-07-22 | Scimed Life Systems, Inc. | Tortuous path injection device and method |
| US6613017B1 (en) | 2000-08-08 | 2003-09-02 | Scimed Life Systems, Inc. | Controlled depth injection device and method |
| US6582400B1 (en) | 2000-10-24 | 2003-06-24 | Scimed Life Systems, Inc. | Variable tip catheter |
| US6530914B1 (en) | 2000-10-24 | 2003-03-11 | Scimed Life Systems, Inc. | Deflectable tip guide in guide system |
| WO2003008005A2 (en) * | 2000-11-08 | 2003-01-30 | Boston Scientific Limited | Catheter and implants for the delivery of therapeutic agents to tissues |
| US6616626B2 (en) * | 2000-12-21 | 2003-09-09 | Scimed Life Systems, Inc. | Infusion devices and method |
| EP1361896A2 (en) * | 2001-01-23 | 2003-11-19 | Boston Scientific Corporation | Localized myocardial injection method for treating ischemic myocardium |
| US6976990B2 (en) * | 2001-01-25 | 2005-12-20 | Percardia, Inc. | Intravascular ventriculocoronary bypass via a septal passageway |
| US6740040B1 (en) | 2001-01-30 | 2004-05-25 | Advanced Cardiovascular Systems, Inc. | Ultrasound energy driven intraventricular catheter to treat ischemia |
| US6887857B2 (en) | 2001-04-27 | 2005-05-03 | Scimed Life Systems, Inc. | Microparticle protection of therapeutic agents |
| US7455657B2 (en) | 2001-06-19 | 2008-11-25 | Boston Scientific Scimed, Inc | Method and apparatus to modify a fluid using a selectively permeable membrane |
| US6702744B2 (en) * | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
| US6623733B1 (en) | 2001-06-27 | 2003-09-23 | Advanced Cardiovascular Systems, Inc. | Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease |
| US6592608B2 (en) * | 2001-12-07 | 2003-07-15 | Biopsy Sciences, Llc | Bioabsorbable sealant |
| US6726714B2 (en) * | 2001-08-09 | 2004-04-27 | Scimed Life Systems, Inc. | Stent delivery system |
| US20030036698A1 (en) * | 2001-08-16 | 2003-02-20 | Robert Kohler | Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts |
| US20030060842A1 (en) * | 2001-09-27 | 2003-03-27 | Yem Chin | Method and apparatus for measuring and controlling blade depth of a tissue cutting apparatus in an endoscopic catheter |
| US6893431B2 (en) | 2001-10-15 | 2005-05-17 | Scimed Life Systems, Inc. | Medical device for delivering patches |
| US8608661B1 (en) | 2001-11-30 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Method for intravascular delivery of a treatment agent beyond a blood vessel wall |
| US6955657B1 (en) | 2001-12-31 | 2005-10-18 | Advanced Cardiovascular Systems, Inc. | Intra-ventricular substance delivery catheter system |
| US6949118B2 (en) * | 2002-01-16 | 2005-09-27 | Percardia, Inc. | Encased implant and methods |
| US7008397B2 (en) * | 2002-02-13 | 2006-03-07 | Percardia, Inc. | Cardiac implant and methods |
| US7169127B2 (en) * | 2002-02-21 | 2007-01-30 | Boston Scientific Scimed, Inc. | Pressure apron direct injection catheter |
| US7218962B2 (en) * | 2002-03-29 | 2007-05-15 | Boston Scientific Scimed, Inc. | Magnetically enhanced injection catheter |
| US7108685B2 (en) | 2002-04-15 | 2006-09-19 | Boston Scientific Scimed, Inc. | Patch stabilization of rods for treatment of cardiac muscle |
| AU2003239418B2 (en) * | 2002-05-08 | 2008-01-31 | The Regents Of The University Of California | System and method for forming a non-ablative cardiac conduction block |
| US20030220661A1 (en) * | 2002-05-21 | 2003-11-27 | Heartstent Corporation | Transmyocardial implant delivery system |
| US7033345B2 (en) * | 2002-05-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Deflectable microimplant delivery system |
| US7361368B2 (en) | 2002-06-28 | 2008-04-22 | Advanced Cardiovascular Systems, Inc. | Device and method for combining a treatment agent and a gel |
| US20040044329A1 (en) * | 2002-08-29 | 2004-03-04 | Trudell Leonard A. | Catheter for cardiac injection and method for delivery of therapeutic agents to specified tissues |
| US7326219B2 (en) | 2002-09-09 | 2008-02-05 | Wilk Patent Development | Device for placing transmyocardial implant |
| JP2004246317A (ja) * | 2002-12-20 | 2004-09-02 | Hitachi Ltd | 冷陰極型フラットパネルディスプレイ |
| US20040147868A1 (en) * | 2003-01-27 | 2004-07-29 | Earl Bardsley | Myocardial implant with collar |
| US7393339B2 (en) | 2003-02-21 | 2008-07-01 | C. R. Bard, Inc. | Multi-lumen catheter with separate distal tips |
| US20040191215A1 (en) * | 2003-03-25 | 2004-09-30 | Michael Froix | Compositions for induction of a therapeutic response |
| US20040254518A1 (en) * | 2003-03-27 | 2004-12-16 | Sun Lee | Device to promote blood flow into the myocardium |
| US7641643B2 (en) | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| US8038991B1 (en) | 2003-04-15 | 2011-10-18 | Abbott Cardiovascular Systems Inc. | High-viscosity hyaluronic acid compositions to treat myocardial conditions |
| US8821473B2 (en) | 2003-04-15 | 2014-09-02 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| US20040243095A1 (en) | 2003-05-27 | 2004-12-02 | Shekhar Nimkar | Methods and apparatus for inserting multi-lumen spit-tip catheters into a blood vessel |
| US8308708B2 (en) * | 2003-07-15 | 2012-11-13 | Abbott Cardiovascular Systems Inc. | Deployment system for myocardial cellular material |
| US7396351B2 (en) | 2003-11-05 | 2008-07-08 | Boston Scientific Scimed, Inc. | Device and method for the delivery of viscous fluids in the body |
| US7678077B2 (en) * | 2004-02-20 | 2010-03-16 | Boston Scientific Scimed, Inc. | Variable depth injection device and method |
| JP4564052B2 (ja) * | 2004-04-08 | 2010-10-20 | サンガモ バイオサイエンシズ インコーポレイテッド | 心筋収縮能調節用の方法及び組成物 |
| WO2005099771A2 (en) * | 2004-04-08 | 2005-10-27 | Sangamo Biosciences, Inc. | Methods and compositions for treating neuropathic and neurodegenerative conditions |
| US20070269477A1 (en) * | 2004-05-05 | 2007-11-22 | Igo Stephen R | Heart Treatment Method |
| US8992454B2 (en) * | 2004-06-09 | 2015-03-31 | Bard Access Systems, Inc. | Splitable tip catheter with bioresorbable adhesive |
| US7470252B2 (en) * | 2004-09-16 | 2008-12-30 | Boston Scientific Scimed, Inc. | Expandable multi-port therapeutic delivery system |
| US7854944B2 (en) | 2004-12-17 | 2010-12-21 | Advanced Cardiovascular Systems, Inc. | Tissue regeneration |
| DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
| US7442187B2 (en) * | 2005-01-27 | 2008-10-28 | Boston Scientific Scimed, Inc. | Multiple needle injection catheter |
| US7972295B2 (en) * | 2005-03-11 | 2011-07-05 | Boston Scientific Scimed, Inc. | Apparatus and methods for delivering a bolus of therapeutic material |
| JP4793806B2 (ja) | 2005-03-22 | 2011-10-12 | Tti・エルビュー株式会社 | イオントフォレーシス装置 |
| US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
| US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
| US8303972B2 (en) * | 2005-04-19 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
| US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
| US8187621B2 (en) * | 2005-04-19 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Methods and compositions for treating post-myocardial infarction damage |
| US20060253068A1 (en) * | 2005-04-20 | 2006-11-09 | Van Bilsen Paul | Use of biocompatible in-situ matrices for delivery of therapeutic cells to the heart |
| US8215957B2 (en) * | 2005-05-12 | 2012-07-10 | Robert Shelton | Dental implant placement locator and method of use |
| WO2007041434A2 (en) * | 2005-09-30 | 2007-04-12 | Tti Ellebeau, Inc. | Iontophoresis apparatus and method for delivery of angiogenic factors to enhance healing of injured tissue |
| JP2009509677A (ja) * | 2005-09-30 | 2009-03-12 | Tti・エルビュー株式会社 | 小胞封入活性物質のイオントフォレーシス送達 |
| US20080125634A1 (en) * | 2006-06-14 | 2008-05-29 | Cornova, Inc. | Method and apparatus for identifying and treating myocardial infarction |
| US7732190B2 (en) * | 2006-07-31 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
| US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
| US9375313B2 (en) * | 2006-09-08 | 2016-06-28 | The Regents Of The University Of California | Intramyocardial patterning for global cardiac resizing and reshaping |
| EP2066387A2 (en) * | 2006-09-12 | 2009-06-10 | Boston Scientific Limited | Variable stiffness direct injection system |
| US20080167592A1 (en) * | 2006-10-26 | 2008-07-10 | Greer Steven E | Preventing or treating wounds with a collodion barrier incorporating active agents |
| US8741326B2 (en) * | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
| US9005672B2 (en) | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
| US8192760B2 (en) * | 2006-12-04 | 2012-06-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating tissue using silk proteins |
| WO2008101003A1 (en) * | 2007-02-13 | 2008-08-21 | Cornova, Inc. | Biocompatible polymers, polymer tie-coats, methods of making and using the same, and products incorporating the polymers |
| JP2010523264A (ja) * | 2007-04-11 | 2010-07-15 | ヘンリー フォード ヘルス システム | 心臓の静脈系を用いた心臓の修復、リサイジング、およびリシェイピング |
| US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
| WO2008154033A2 (en) * | 2007-06-11 | 2008-12-18 | Symphony Medical, Inc. | Cardiac patterning for improving diastolic function |
| US8086324B1 (en) * | 2007-09-27 | 2011-12-27 | Pacesetter, Inc. | Intrapericardial lead with distal region configured to optimize lead extraction |
| CN101918065A (zh) * | 2007-10-17 | 2010-12-15 | 巴德阿克塞斯系统股份有限公司 | 具有扩大的动脉内腔的导管 |
| CN101918066B (zh) * | 2007-10-17 | 2013-07-31 | 巴德阿克塞斯系统股份有限公司 | 分裂末端导管的制造方法及分裂末端导管设备 |
| US8500697B2 (en) * | 2007-10-19 | 2013-08-06 | Pressure Products Medical Supplies, Inc. | Transseptal guidewire |
| US8066660B2 (en) | 2007-10-26 | 2011-11-29 | C. R. Bard, Inc. | Split-tip catheter including lateral distal openings |
| US8292841B2 (en) | 2007-10-26 | 2012-10-23 | C. R. Bard, Inc. | Solid-body catheter including lateral distal openings |
| WO2009059220A1 (en) | 2007-11-01 | 2009-05-07 | C.R. Bard, Inc. | Catheter assembly including triple lumen tip |
| US9579485B2 (en) | 2007-11-01 | 2017-02-28 | C. R. Bard, Inc. | Catheter assembly including a multi-lumen configuration |
| US7962223B2 (en) * | 2007-11-16 | 2011-06-14 | Boston Scientific Scimed, Inc. | Ablation probe for drug release in tissue ablation procedures |
| US7963947B2 (en) * | 2008-01-16 | 2011-06-21 | Pressure Products Medical Supplies, Inc. | Apparatus, system, and method of shielding the sharp tip of a transseptal guidewire |
| US20090209940A1 (en) * | 2008-02-15 | 2009-08-20 | Spire Corporation | Fusion manufacture of multi-lumen catheters |
| US20090205189A1 (en) * | 2008-02-15 | 2009-08-20 | Spire Corporation | Manufacture of fixed tip catheters |
| US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
| BR112012021347A2 (pt) | 2008-02-26 | 2019-09-24 | Jenavalve Tecnology Inc | stent para posicionamento e ancoragem de uma prótese valvular em um local de implantação no coração de um paciente |
| US8801665B2 (en) * | 2008-04-10 | 2014-08-12 | Henry Ford Health System | Apparatus and method for controlled depth of injection into myocardial tissue |
| US20100069760A1 (en) * | 2008-09-17 | 2010-03-18 | Cornova, Inc. | Methods and apparatus for analyzing and locally treating a body lumen |
| US20100160772A1 (en) * | 2008-12-18 | 2010-06-24 | Medtronic, Inc. | Adaptable Image Guided Delivery System |
| US10856978B2 (en) | 2010-05-20 | 2020-12-08 | Jenavalve Technology, Inc. | Catheter system |
| AU2011257298B2 (en) | 2010-05-25 | 2014-07-31 | Jenavalve Technology Inc. | Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent |
| US8956376B2 (en) | 2011-06-30 | 2015-02-17 | The Spectranetics Corporation | Reentry catheter and method thereof |
| WO2013003757A2 (en) | 2011-06-30 | 2013-01-03 | The Spectranetics Corporation | Reentry catheter and method thereof |
| US8998936B2 (en) | 2011-06-30 | 2015-04-07 | The Spectranetics Corporation | Reentry catheter and method thereof |
| US8668344B2 (en) | 2011-11-30 | 2014-03-11 | Izi Medical Products | Marker sphere including edged opening to aid in molding |
| US8661573B2 (en) | 2012-02-29 | 2014-03-04 | Izi Medical Products | Protective cover for medical device having adhesive mechanism |
| USD748252S1 (en) | 2013-02-08 | 2016-01-26 | C. R. Bard, Inc. | Multi-lumen catheter tip |
| CN105491978A (zh) | 2013-08-30 | 2016-04-13 | 耶拿阀门科技股份有限公司 | 用于假体瓣膜的径向可折叠框架及其制造方法 |
| WO2016011091A1 (en) | 2014-07-14 | 2016-01-21 | C. R. Bard, Inc. | Apparatuses, systems, and methods for inserting split tip catheters having enhanced stiffening and guiding features |
| JP6829692B2 (ja) | 2015-03-20 | 2021-02-10 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 心臓弁プロテーゼ送出システム及び導入体シースにより心臓弁プロテーゼを送出するための方法 |
| EP4403138A3 (en) | 2015-05-01 | 2024-10-09 | JenaValve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
| EP4183371A1 (en) | 2016-05-13 | 2023-05-24 | JenaValve Technology, Inc. | Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system |
| US10707531B1 (en) | 2016-09-27 | 2020-07-07 | New Dominion Enterprises Inc. | All-inorganic solvents for electrolytes |
| US11197754B2 (en) | 2017-01-27 | 2021-12-14 | Jenavalve Technology, Inc. | Heart valve mimicry |
| WO2024102411A1 (en) | 2022-11-09 | 2024-05-16 | Jenavalve Technology, Inc. | Catheter system for sequential deployment of an expandable implant |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5370675A (en) * | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
| US4760131A (en) * | 1986-04-23 | 1988-07-26 | Collagen Corporation | Wound-healing composition |
| US4790311A (en) * | 1986-06-03 | 1988-12-13 | Ruiz Oscar F | Radio frequency angioplasty catheter system |
| US4896671A (en) * | 1988-08-01 | 1990-01-30 | C. R. Bard, Inc. | Catheter with contoured ablation electrode |
| US5047026A (en) * | 1989-09-29 | 1991-09-10 | Everest Medical Corporation | Electrosurgical implement for tunneling through tissue |
| US5364393A (en) * | 1990-07-02 | 1994-11-15 | Heart Technology, Inc. | Tissue dissipative recanalization catheter |
| US5700259A (en) * | 1990-09-24 | 1997-12-23 | Plc Medical Systems, Inc. | Thoracoscopic transmyocardial revascularization handpiece assembly |
| US5093877A (en) * | 1990-10-30 | 1992-03-03 | Advanced Cardiovascular Systems | Optical fiber lasing apparatus lens |
| US5389096A (en) * | 1990-12-18 | 1995-02-14 | Advanced Cardiovascular Systems | System and method for percutaneous myocardial revascularization |
| US5380316A (en) * | 1990-12-18 | 1995-01-10 | Advanced Cardiovascular Systems, Inc. | Method for intra-operative myocardial device revascularization |
| US5683366A (en) * | 1992-01-07 | 1997-11-04 | Arthrocare Corporation | System and method for electrosurgical tissue canalization |
| US5697882A (en) * | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | System and method for electrosurgical cutting and ablation |
| ES2116355T3 (es) * | 1992-01-13 | 1998-07-16 | Schneider Usa Inc | Dispositivo de corte para cateter de aterectomia. |
| US5607405A (en) * | 1992-05-19 | 1997-03-04 | Decker; Rand A. | Surgical insertion device and method |
| US5620414A (en) * | 1992-06-30 | 1997-04-15 | Campbell, Jr.; Robert M. | Apparatus and method for effecting surgical incision through use of a fluid jet |
| US5287861A (en) * | 1992-10-30 | 1994-02-22 | Wilk Peter J | Coronary artery by-pass method and associated catheter |
| US5261889A (en) * | 1992-11-24 | 1993-11-16 | Boston Scientific Corporation | Injection therapy catheter |
| US5403311A (en) * | 1993-03-29 | 1995-04-04 | Boston Scientific Corporation | Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue |
| US5336222A (en) * | 1993-03-29 | 1994-08-09 | Boston Scientific Corporation | Integrated catheter for diverse in situ tissue therapy |
| US5431649A (en) * | 1993-08-27 | 1995-07-11 | Medtronic, Inc. | Method and apparatus for R-F ablation |
| US5405376A (en) * | 1993-08-27 | 1995-04-11 | Medtronic, Inc. | Method and apparatus for ablation |
| US5651785A (en) * | 1993-09-20 | 1997-07-29 | Abela Laser Systems, Inc. | Optical fiber catheter and method |
| WO1995008355A1 (en) * | 1993-09-24 | 1995-03-30 | Baxter International Inc. | Methods for enhancing vascularization of implant devices |
| FR2718944B1 (fr) * | 1994-04-20 | 1996-08-30 | Pierre Roussouly | Dispositif de stabilisation d'ancrage orthopédique. |
| US5681278A (en) * | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
| US5681308A (en) * | 1994-06-24 | 1997-10-28 | Stuart D. Edwards | Ablation apparatus for cardiac chambers |
| US5593405A (en) * | 1994-07-16 | 1997-01-14 | Osypka; Peter | Fiber optic endoscope |
| US5591159A (en) * | 1994-11-09 | 1997-01-07 | Taheri; Syde A. | Transcavitary myocardial perfusion apparatus |
| US5551427A (en) * | 1995-02-13 | 1996-09-03 | Altman; Peter A. | Implantable device for the effective elimination of cardiac arrhythmogenic sites |
| WO1996035469A1 (en) * | 1995-05-10 | 1996-11-14 | Cardiogenesis Corporation | System for treating or diagnosing heart tissue |
| US5797870A (en) * | 1995-06-07 | 1998-08-25 | Indiana University Foundation | Pericardial delivery of therapeutic and diagnostic agents |
| US5672174A (en) * | 1995-08-15 | 1997-09-30 | Rita Medical Systems, Inc. | Multiple antenna ablation apparatus and method |
| DE19537084A1 (de) * | 1995-10-05 | 1997-04-10 | Sievers Hans Hinrich Prof Dr M | Katheter zur transmyokardialen Revaskularisation |
| US5769843A (en) * | 1996-02-20 | 1998-06-23 | Cormedica | Percutaneous endomyocardial revascularization |
| US5713894A (en) * | 1996-02-27 | 1998-02-03 | Murphy-Chutorian; Douglas | Combined mechanical/optical system for transmyocardial revascularization |
| US5810836A (en) * | 1996-03-04 | 1998-09-22 | Myocardial Stents, Inc. | Device and method for trans myocardial revascularization (TMR) |
| US5725521A (en) * | 1996-03-29 | 1998-03-10 | Eclipse Surgical Technologies, Inc. | Depth stop apparatus and method for laser-assisted transmyocardial revascularization and other surgical applications |
| US5725523A (en) * | 1996-03-29 | 1998-03-10 | Mueller; Richard L. | Lateral-and posterior-aspect method and apparatus for laser-assisted transmyocardial revascularization and other surgical applications |
| IL118352A0 (en) * | 1996-05-21 | 1996-09-12 | Sudai Amnon | Apparatus and methods for revascularization |
| DE29609350U1 (de) * | 1996-05-24 | 1996-08-29 | Dr.-Ing. P. Osypka mbH Gesellschaft für Medizintechnik, 79639 Grenzach-Wyhlen | Vorrichtung zum Perforieren der Herzwand |
| AU3911097A (en) * | 1996-08-08 | 1998-02-25 | Localmed, Inc. | Transmural drug delivery method and apparatus |
| US5871495A (en) * | 1996-09-13 | 1999-02-16 | Eclipse Surgical Technologies, Inc. | Method and apparatus for mechanical transmyocardial revascularization of the heart |
| US6030377A (en) * | 1996-10-21 | 2000-02-29 | Plc Medical Systems, Inc. | Percutaneous transmyocardial revascularization marking system |
| US6053924A (en) | 1996-11-07 | 2000-04-25 | Hussein; Hany | Device and method for trans myocardial revascularization |
| US6042581A (en) | 1996-11-08 | 2000-03-28 | Thomas J. Fogarty | Transvascular TMR device and method |
| US6056742A (en) | 1997-02-03 | 2000-05-02 | Eclipse Surgical Technologies, Inc. | Revascularization with laser outputs |
| US6045565A (en) | 1997-11-04 | 2000-04-04 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization growth factor mediums and method |
| US6056743A (en) | 1997-11-04 | 2000-05-02 | Scimed Life Systems, Inc. | Percutaneous myocardial revascularization device and method |
| WO2000015146A1 (en) | 1998-09-10 | 2000-03-23 | Percardia, Inc. | Transmyocardial shunt for left ventricular revascularization |
| US6312402B1 (en) | 1998-09-24 | 2001-11-06 | Ekos Corporation | Ultrasound catheter for improving blood flow to the heart |
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1998
- 1998-11-02 US US09/184,220 patent/US6045565A/en not_active Expired - Fee Related
- 1998-11-03 EP EP98957545A patent/EP1028661A4/en not_active Withdrawn
- 1998-11-03 JP JP2000518598A patent/JP4282898B2/ja not_active Expired - Fee Related
- 1998-11-03 DE DE1028661T patent/DE1028661T1/de active Pending
- 1998-11-03 WO PCT/US1998/023396 patent/WO1999022655A1/en not_active Ceased
- 1998-11-03 CA CA002307102A patent/CA2307102A1/en not_active Abandoned
-
2000
- 2000-03-01 US US09/516,531 patent/US6238406B1/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2758024C1 (ru) * | 2021-03-05 | 2021-10-25 | Юрий Леонидович Шевченко | Способ индукции экстракардиальной реваскуляризации миокарда у больных ишемической болезнью сердца |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999022655A1 (en) | 1999-05-14 |
| US6238406B1 (en) | 2001-05-29 |
| JP2003521945A (ja) | 2003-07-22 |
| EP1028661A4 (en) | 2003-01-08 |
| US6045565A (en) | 2000-04-04 |
| EP1028661A1 (en) | 2000-08-23 |
| JP4282898B2 (ja) | 2009-06-24 |
| DE1028661T1 (de) | 2001-03-15 |
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