CA2307000A1 - Veterinary vaccines - Google Patents

Veterinary vaccines Download PDF

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Publication number
CA2307000A1
CA2307000A1 CA002307000A CA2307000A CA2307000A1 CA 2307000 A1 CA2307000 A1 CA 2307000A1 CA 002307000 A CA002307000 A CA 002307000A CA 2307000 A CA2307000 A CA 2307000A CA 2307000 A1 CA2307000 A1 CA 2307000A1
Authority
CA
Canada
Prior art keywords
clostridium
vaccine composition
vaccine
antigens
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002307000A
Other languages
French (fr)
Other versions
CA2307000C (en
Inventor
Richard Buchta
Christopher Leigh Schwartzkoff
Philip Ralph Lehrbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoetis Services LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9722035.4A external-priority patent/GB9722035D0/en
Application filed by Individual filed Critical Individual
Publication of CA2307000A1 publication Critical patent/CA2307000A1/en
Application granted granted Critical
Publication of CA2307000C publication Critical patent/CA2307000C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to vaccines which are suitable for the prevention of clostridial diseases of sheep (and lambs), providing an effective immunity for up to a year or more following a single injection or dose.

Claims (9)

1. A sheep vaccine composition comprising:
a) an oily adjuvant acceptable for veterinary purposes comprising:
i) a white mineral oil having a molecular weight of about 250 to 300 and ii) a mannitol oleate emulsifier and b) an aqueous phase comprising one or more clostridial antigens.
2. A vaccine composition as claimed in claim 1 wherein the vaccine has a viscosity of about 200mPas or less.
3. A vaccine composition as claimed in claim 1 or claim 2 wherein the white mineral oil is between about 50% and about 70% by weight of the emulsion.
4. A vaccine composition as claimed in any one of claims 1 to 3 wherein the mannitol oleate emulsifier is between about 2% and about 10% by volume of the emulsion.
5. A vaccine composition as claimed in any one of claims 1 to 4 wherein the mannitol oleate emulsifier is an anhydromannitol ether octadecanoate.
6. A vaccine composition as claimed in claim 5 wherein the vaccine comprises one or more of the following Clostridial antigens: Clostridium perfringens type A, B, C
and D, Clostridium septicum, Clostridium tetani, Clostridium chauvoei, Clostridium novyi type B, Clostridium sordelli, Clostridium haemolyticum and Clostridium chauvoei.
7. A vaccine composition as claimed in any one of claims 1 to 6 wherein the vaccine comprises antigens useful in the treatment of one or more of the following:
Lamb dysentery, Pulpy Kidney disease (enterotoxaemia), Malignant Oedema (blood poisoning), Tetanus, Blackleg disease and Black disease.
8. A vaccine composition as claimed in any one of claims 1 to 7 wherein the vaccine further comprises antigens against a non-clostridial disease.
9. A vaccine composition as claimed in claim 8 wherein the vaccine comprises Corynebacterium antigens.
CA2307000A 1997-10-17 1998-10-16 Veterinary vaccines Expired - Lifetime CA2307000C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9722035.4 1997-10-17
GBGB9722035.4A GB9722035D0 (en) 1997-10-17 1997-10-17 Veterinary vaccines
PCT/AU1998/000865 WO1999020305A1 (en) 1997-10-17 1998-10-16 Veterinary vaccines

Publications (2)

Publication Number Publication Date
CA2307000A1 true CA2307000A1 (en) 1999-04-29
CA2307000C CA2307000C (en) 2011-01-04

Family

ID=25641911

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2307000A Expired - Lifetime CA2307000C (en) 1997-10-17 1998-10-16 Veterinary vaccines

Country Status (5)

Country Link
EP (1) EP1023083A4 (en)
AU (1) AU753804B2 (en)
CA (1) CA2307000C (en)
NZ (1) NZ503636A (en)
WO (1) WO1999020305A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2824279B1 (en) * 2001-05-04 2004-05-28 Seppic Sa CONCENTRATED W / O EMULSION
FR2824269B1 (en) * 2001-09-03 2012-03-02 Seppic Sa ADJUVANT COMPOSITION CONSISTING OF 1% TO 15% OF SURFACTANTS AT GLOBAL HLB INCLUDING BETWEEN 5 AND 8 AND 85% TO 99% OF BODY FATS
GB2448440B (en) * 2005-12-15 2011-05-04 Hancroft Pty Ltd A method for preventing reduced feed intake in animals and treatment of disease conditions
FR2903602B1 (en) * 2006-07-12 2012-10-26 Seppic Sa INJECTABLE FORMULATION WITH PROLONGED RELEASE OF ACTIVE INGREDIENTS, PROCESS FOR PREPARING THE SAME
FR2922767B1 (en) 2007-10-24 2009-12-18 Seppic Sa PROCESS FOR PREPARING A VACCINE COMPOSITION COMPRISING AT LEAST ONE ANTIGEN AND AT LEAST ONE ADJUVANT
CN106177935A (en) * 2016-08-19 2016-12-07 齐鲁动物保健品有限公司 A kind of ruminant clostridial disease tetrad inactivated vaccine and preparation method thereof
GB201718251D0 (en) * 2017-11-03 2017-12-20 Univ Sydney Vaccine Compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1128325A (en) * 1964-11-11 1968-09-25 Wellcome Found Improvements in water-in-oil emulsion vaccines
US3843451A (en) * 1970-08-20 1974-10-22 Burroughs Wellcome Co Microorganism production
FR2649012B1 (en) * 1989-07-03 1991-10-25 Seppic Sa INJECTABLE MULTIPHASIC EMULSIONS
FR2717694B1 (en) * 1994-03-22 1996-05-03 Seppic Sa A composition comprising a recombinant plasmid and its uses as a vaccine and medicament.
TW410158B (en) * 1995-11-30 2000-11-01 Chemo Sero Therapeut Res Inst Oil adjuvant vaccine and method for preparing same
GB9626865D0 (en) * 1996-12-24 1997-02-12 Cyanamid Websters Pty Limited Veterinary vaccines

Also Published As

Publication number Publication date
EP1023083A1 (en) 2000-08-02
AU753804B2 (en) 2002-10-31
WO1999020305A1 (en) 1999-04-29
EP1023083A4 (en) 2006-06-14
AU9616198A (en) 1999-05-10
WO1999020305A8 (en) 1999-07-08
CA2307000C (en) 2011-01-04
NZ503636A (en) 2002-05-31

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Effective date: 20181016