WO1999002132A3 - Use of submicron oil-in-water emulsions with dna vaccines - Google Patents
Use of submicron oil-in-water emulsions with dna vaccines Download PDFInfo
- Publication number
- WO1999002132A3 WO1999002132A3 PCT/US1998/014310 US9814310W WO9902132A3 WO 1999002132 A3 WO1999002132 A3 WO 1999002132A3 US 9814310 W US9814310 W US 9814310W WO 9902132 A3 WO9902132 A3 WO 9902132A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- submicron oil
- water emulsions
- dna vaccines
- nucleic acid
- adjuvant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98933312A EP1006999A2 (en) | 1997-07-08 | 1998-07-08 | Use of submicron oil-in-water emulsions with dna vaccines |
JP50895399A JP2002509545A (en) | 1997-07-08 | 1998-07-08 | Use of submicron oil-in-water emulsion with DNA vaccine |
AU82982/98A AU8298298A (en) | 1997-07-08 | 1998-07-08 | Use of submicron oil-in-water emulsions with dna vaccines |
CA002295740A CA2295740A1 (en) | 1997-07-08 | 1998-07-08 | Use of submicron oil-in-water emulsions with dna vaccines |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5194497P | 1997-07-08 | 1997-07-08 | |
US5475697P | 1997-08-05 | 1997-08-05 | |
US60/051,944 | 1997-08-05 | ||
US60/054,756 | 1997-08-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999002132A2 WO1999002132A2 (en) | 1999-01-21 |
WO1999002132A3 true WO1999002132A3 (en) | 1999-08-12 |
Family
ID=26729981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/014310 WO1999002132A2 (en) | 1997-07-08 | 1998-07-08 | Use of submicron oil-in-water emulsions with dna vaccines |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1006999A2 (en) |
JP (1) | JP2002509545A (en) |
AU (1) | AU8298298A (en) |
CA (1) | CA2295740A1 (en) |
WO (1) | WO1999002132A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8206749B1 (en) * | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
IL146382A0 (en) | 1999-05-13 | 2002-07-25 | American Cyanamid Co | Adjuvant combination formulations |
AR045702A1 (en) * | 2001-10-03 | 2005-11-09 | Chiron Corp | COMPOSITIONS OF ASSISTANTS. |
GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
EP2257306B1 (en) * | 2008-03-25 | 2014-05-07 | Juvaris Biotherapeutics, Inc. | Enhancement of an immune response by administration of a cationic lipid-dna complex (cldc) |
GB0822001D0 (en) * | 2008-12-02 | 2009-01-07 | Glaxosmithkline Biolog Sa | Vaccine |
MX2012011340A (en) * | 2010-03-29 | 2012-11-16 | Novartis Ag | Composition comprising the amyloid beta 1-6 peptide coupled to a virus-like particle and an adjuvant. |
NZ606591A (en) | 2010-07-06 | 2015-02-27 | Novartis Ag | Cationic oil-in-water emulsions |
JP6120839B2 (en) | 2011-07-06 | 2017-04-26 | ノバルティス アーゲー | Cationic oil-in-water emulsion |
EP2729125B1 (en) | 2011-07-06 | 2017-12-13 | GlaxoSmithKline Biologicals SA | Oil-in-water emulsions that contain nucleic acids |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990014837A1 (en) * | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
WO1994016737A1 (en) * | 1993-01-26 | 1994-08-04 | Weiner David B | Compositions and methods for delivery of genetic material |
WO1995033835A1 (en) * | 1994-06-02 | 1995-12-14 | Chiron Corporation | Nucleic acid immunization using a virus-based infection/transfection system |
-
1998
- 1998-07-08 JP JP50895399A patent/JP2002509545A/en active Pending
- 1998-07-08 AU AU82982/98A patent/AU8298298A/en not_active Abandoned
- 1998-07-08 WO PCT/US1998/014310 patent/WO1999002132A2/en not_active Application Discontinuation
- 1998-07-08 CA CA002295740A patent/CA2295740A1/en not_active Abandoned
- 1998-07-08 EP EP98933312A patent/EP1006999A2/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990014837A1 (en) * | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
WO1994016737A1 (en) * | 1993-01-26 | 1994-08-04 | Weiner David B | Compositions and methods for delivery of genetic material |
WO1995033835A1 (en) * | 1994-06-02 | 1995-12-14 | Chiron Corporation | Nucleic acid immunization using a virus-based infection/transfection system |
Non-Patent Citations (1)
Title |
---|
DATABASE DIALOG MEDLINE 1 January 1900 (1900-01-01), Database accession no. 08554776 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999002132A2 (en) | 1999-01-21 |
AU8298298A (en) | 1999-02-08 |
CA2295740A1 (en) | 1999-01-21 |
JP2002509545A (en) | 2002-03-26 |
EP1006999A2 (en) | 2000-06-14 |
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