CA2306634A1 - Suspension packing cell lines for retrovirus vectors - Google Patents

Suspension packing cell lines for retrovirus vectors Download PDF

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Publication number
CA2306634A1
CA2306634A1 CA002306634A CA2306634A CA2306634A1 CA 2306634 A1 CA2306634 A1 CA 2306634A1 CA 002306634 A CA002306634 A CA 002306634A CA 2306634 A CA2306634 A CA 2306634A CA 2306634 A1 CA2306634 A1 CA 2306634A1
Authority
CA
Canada
Prior art keywords
cell lines
retrovirus vectors
packing cell
suspension
suspension packing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002306634A
Other languages
French (fr)
Other versions
CA2306634C (en
Inventor
Stefan Seeber
Stefan Koch
Thorsten Gutjahr
Ulrich Steegmans
Rudiger Ruger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2306634A1 publication Critical patent/CA2306634A1/en
Application granted granted Critical
Publication of CA2306634C publication Critical patent/CA2306634C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13051—Methods of production or purification of viral material
    • C12N2740/13052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a packing cell line fully growing in a suspension, which is transfected with a retrovirus plasmid or transduced with a retrovirus vector. The invention aslo relates to a method for the production of said cell lines from suspension cell lines or adheringly growing cell lines.
CA002306634A 1997-10-25 1998-10-22 Suspension packing cell lines for retrovirus vectors Expired - Fee Related CA2306634C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP97118583 1997-10-25
EP97118583.0 1997-10-25
EP97121724.5 1997-12-10
EP97121724 1997-12-10
PCT/EP1998/006714 WO1999021967A1 (en) 1997-10-25 1998-10-22 Suspension packing cell lines for retrovirus vectors

Publications (2)

Publication Number Publication Date
CA2306634A1 true CA2306634A1 (en) 1999-05-06
CA2306634C CA2306634C (en) 2005-04-12

Family

ID=26145852

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002306634A Expired - Fee Related CA2306634C (en) 1997-10-25 1998-10-22 Suspension packing cell lines for retrovirus vectors

Country Status (16)

Country Link
EP (1) EP1025207B1 (en)
JP (1) JP3517399B2 (en)
KR (1) KR100359542B1 (en)
CN (1) CN1277631A (en)
AT (1) ATE304048T1 (en)
AU (1) AU729986B2 (en)
BR (1) BR9812960A (en)
CA (1) CA2306634C (en)
DE (1) DE59813048D1 (en)
ES (1) ES2248920T3 (en)
HU (1) HUP0004240A2 (en)
IL (1) IL135541A (en)
NO (1) NO20002013L (en)
NZ (1) NZ503827A (en)
TR (1) TR200001125T2 (en)
WO (1) WO1999021967A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007000318A2 (en) * 2005-06-27 2007-01-04 Max-Delbrück-Centrum Für Molekulare Medizin (Mdc) Berlin-Buch T cell lime-based packaging cell line for the production of retroviruses by enriching of cd3 expressing cells
US10316333B2 (en) 2009-06-17 2019-06-11 Tocagen Inc. Producer cells for replication competent retroviral vectors

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100507794B1 (en) * 2003-02-11 2005-08-17 한미약품 주식회사 Method for preparing concentrated retroviral particle dispersion
CN111286517A (en) * 2018-12-07 2020-06-16 珠海联邦制药股份有限公司 Packaging method of replication-defective retrovirus and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4059485A (en) * 1976-11-03 1977-11-22 Monsanto Company Adaptation of cell lines to suspension culture
RU1347448C (en) * 1985-09-27 1995-04-10 Институт полиомиелита и вирусных энцефалитов Российской АМН Strain taurus-1 of heteroploid cells of calf kidney used for virus cultivation
CA2001815C (en) * 1988-10-31 2002-09-03 Wen-Hwa Lee Products and methods for controlling the suppression of the neoplastic phenotype
DE19612966B4 (en) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK cells and methods of propagating influenza viruses

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007000318A2 (en) * 2005-06-27 2007-01-04 Max-Delbrück-Centrum Für Molekulare Medizin (Mdc) Berlin-Buch T cell lime-based packaging cell line for the production of retroviruses by enriching of cd3 expressing cells
WO2007000318A3 (en) * 2005-06-27 2007-04-19 Max Delbrueck Centrum T cell lime-based packaging cell line for the production of retroviruses by enriching of cd3 expressing cells
US10316333B2 (en) 2009-06-17 2019-06-11 Tocagen Inc. Producer cells for replication competent retroviral vectors
US11060112B2 (en) 2009-06-17 2021-07-13 Denovo Biopharma Llc Producer cells for replication competent retroviral vectors

Also Published As

Publication number Publication date
JP2001520879A (en) 2001-11-06
JP3517399B2 (en) 2004-04-12
NO20002013D0 (en) 2000-04-17
TR200001125T2 (en) 2000-09-21
DE59813048D1 (en) 2005-10-13
CN1277631A (en) 2000-12-20
KR100359542B1 (en) 2002-10-31
CA2306634C (en) 2005-04-12
BR9812960A (en) 2000-08-08
AU729986B2 (en) 2001-02-22
EP1025207A1 (en) 2000-08-09
EP1025207B1 (en) 2005-09-07
IL135541A0 (en) 2001-05-20
IL135541A (en) 2004-02-19
HUP0004240A2 (en) 2001-03-28
NZ503827A (en) 2001-06-29
AU1231399A (en) 1999-05-17
ES2248920T3 (en) 2006-03-16
WO1999021967A1 (en) 1999-05-06
ATE304048T1 (en) 2005-09-15
KR20010031387A (en) 2001-04-16
NO20002013L (en) 2000-04-17

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