CA2304720A1 - Complexes d'apolipoproteine e/facteur de croissance et procedes d'utilisation - Google Patents

Complexes d'apolipoproteine e/facteur de croissance et procedes d'utilisation Download PDF

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Publication number
CA2304720A1
CA2304720A1 CA002304720A CA2304720A CA2304720A1 CA 2304720 A1 CA2304720 A1 CA 2304720A1 CA 002304720 A CA002304720 A CA 002304720A CA 2304720 A CA2304720 A CA 2304720A CA 2304720 A1 CA2304720 A1 CA 2304720A1
Authority
CA
Canada
Prior art keywords
apolipoprotein
complex
composition
apoe
ngf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002304720A
Other languages
English (en)
Inventor
William D. Matthew
Warren J. Strittmatter
Catherine R. Gutman
Stephanie M. Fullerton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2304720A1 publication Critical patent/CA2304720A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des compositions comprenant des complexes d'apolipoprotéine E et de facteur de croissance du tissu nerveux, de neurotrophine 4 ou d'interféron ?. L'apolipoprotéine E peut présenter n'importe quelle isoforme, mais elle sera de préférence constituée par l'apolipoprotéine E3. Les complexes préférés sont des complexes covalents d'apolipoprotéine E et de facteur de croissance du tissu nerveux, d'interféron ? ou de neurotrophine 4. L'invention se rapporte en outre à des procédés permettant d'augmenter la survie de cellules neuronales en administrant une composition comprenant un complexe d'apolipoprotéine E et de facteur de croissance du tissu nerveux ou de neurotrophine 4. L'invention concerne aussi des procédés permettant d'administrer des compositions comprenant des complexes d'apolipoprotéine E et d'interféron ? dans le but de protéger des infections virales, de traiter le diabète sucré, l'ostéolyse, les lésions sanguines, et de produire des effets anti-tumoraux. Les procédés de la présente invention peuvent être utilisés in vitro et in vivo.
CA002304720A 1997-09-30 1998-09-29 Complexes d'apolipoproteine e/facteur de croissance et procedes d'utilisation Abandoned CA2304720A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6053397P 1997-09-30 1997-09-30
US60/060,533 1997-09-30
PCT/US1998/020591 WO1999016460A2 (fr) 1997-09-30 1998-09-29 Complexes d'apolipoproteine e/facteur de croissance et procedes d'utilisation

Publications (1)

Publication Number Publication Date
CA2304720A1 true CA2304720A1 (fr) 1999-04-08

Family

ID=22030099

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002304720A Abandoned CA2304720A1 (fr) 1997-09-30 1998-09-29 Complexes d'apolipoproteine e/facteur de croissance et procedes d'utilisation

Country Status (5)

Country Link
EP (1) EP1019081A2 (fr)
JP (1) JP2001518449A (fr)
AU (1) AU9676598A (fr)
CA (1) CA2304720A1 (fr)
WO (1) WO1999016460A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19745950A1 (de) * 1997-10-17 1999-04-22 Dds Drug Delivery Service Ges Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation
AR035016A1 (es) * 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
US20040120925A1 (en) * 2001-03-12 2004-06-24 Masahiro Toda Remedies for nerve damages
GB0329254D0 (en) * 2003-12-17 2004-01-21 Univ Manchester Treatment of viral infections
EP1988920A1 (fr) 2006-02-02 2008-11-12 Rinat Neuroscience Corp. Procédés de traitement de l'obésité par administration d'un antagoniste trkb
WO2017165515A1 (fr) * 2016-03-23 2017-09-28 The Research Institute At Nationwide Children's Hospital Stimulation de la croissance osseuse à l'aide d'apolipoprotéine e

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
US5364769A (en) * 1990-09-25 1994-11-15 Genentech, Inc. Nucleic acid encoding neurotrophic factor four (NT-4), vectors, host cells and methods of production
US5604202A (en) * 1990-11-13 1997-02-18 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Use of NGF growth factors to treat drug-induced neuropathy
US6277828B1 (en) * 1993-08-20 2001-08-21 Syntex (U.S.A.) Inc. Pharmaceutical formulations of nerve growth factor
EP0731108A1 (fr) * 1995-03-10 1996-09-11 Boehringer Mannheim Gmbh Procédé de fabrication d'un agent thérapeutique pour la régénération d'oligodendrocytes

Also Published As

Publication number Publication date
EP1019081A2 (fr) 2000-07-19
WO1999016460A3 (fr) 1999-06-17
AU9676598A (en) 1999-04-23
JP2001518449A (ja) 2001-10-16
WO1999016460A2 (fr) 1999-04-08

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Legal Events

Date Code Title Description
FZDE Discontinued