CA2303832A1 - Inhibiteurs de thrombine - Google Patents

Inhibiteurs de thrombine Download PDF

Info

Publication number
CA2303832A1
CA2303832A1 CA002303832A CA2303832A CA2303832A1 CA 2303832 A1 CA2303832 A1 CA 2303832A1 CA 002303832 A CA002303832 A CA 002303832A CA 2303832 A CA2303832 A CA 2303832A CA 2303832 A1 CA2303832 A1 CA 2303832A1
Authority
CA
Canada
Prior art keywords
mammal
composition
administering
treating
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002303832A
Other languages
English (en)
Inventor
Craig Coburn
Adel M. Naylor-Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806034.6A external-priority patent/GB9806034D0/en
Application filed by Individual filed Critical Individual
Publication of CA2303832A1 publication Critical patent/CA2303832A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

On décrit un composé qui inhibe la thrombine humaine et qui correspond à la structure générale (I) telle que la structure (II).
CA002303832A 1997-09-30 1998-09-25 Inhibiteurs de thrombine Abandoned CA2303832A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6053697P 1997-09-30 1997-09-30
US60/060,536 1997-09-30
GBGB9806034.6A GB9806034D0 (en) 1998-03-20 1998-03-20 Thrombin inhibitors
GB9806034.6 1998-03-20
PCT/US1998/020174 WO1999016750A1 (fr) 1997-09-30 1998-09-25 Inhibiteurs de thrombine

Publications (1)

Publication Number Publication Date
CA2303832A1 true CA2303832A1 (fr) 1999-04-08

Family

ID=26313327

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002303832A Abandoned CA2303832A1 (fr) 1997-09-30 1998-09-25 Inhibiteurs de thrombine

Country Status (5)

Country Link
EP (1) EP1027333A4 (fr)
JP (1) JP2001518466A (fr)
AU (1) AU740170B2 (fr)
CA (1) CA2303832A1 (fr)
WO (1) WO1999016750A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7857522B2 (en) * 2007-01-31 2010-12-28 Siemens Industry, Inc. Rolling mill oil film bearing

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2051702T3 (es) * 1986-04-01 1994-07-01 Wako Pure Chem Ind Ltd Derivados peptidicos y metodo para medir la actividad de sustancias fisiologicamente activas usandolos como sustratos.
DE4306873A1 (de) * 1993-03-05 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Aminopyridine-Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors

Also Published As

Publication number Publication date
JP2001518466A (ja) 2001-10-16
EP1027333A4 (fr) 2000-11-08
AU740170B2 (en) 2001-11-01
EP1027333A1 (fr) 2000-08-16
WO1999016750A1 (fr) 1999-04-08
AU9583998A (en) 1999-04-23

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Legal Events

Date Code Title Description
FZDE Dead