AU740170B2 - Thrombin inhibitors - Google Patents

Thrombin inhibitors Download PDF

Info

Publication number
AU740170B2
AU740170B2 AU95839/98A AU9583998A AU740170B2 AU 740170 B2 AU740170 B2 AU 740170B2 AU 95839/98 A AU95839/98 A AU 95839/98A AU 9583998 A AU9583998 A AU 9583998A AU 740170 B2 AU740170 B2 AU 740170B2
Authority
AU
Australia
Prior art keywords
mammal
compound
treating
composition
preventing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU95839/98A
Other languages
English (en)
Other versions
AU9583998A (en
Inventor
Craig Coburn
Adel M. Naylor-Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806034.6A external-priority patent/GB9806034D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU9583998A publication Critical patent/AU9583998A/en
Application granted granted Critical
Publication of AU740170B2 publication Critical patent/AU740170B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
AU95839/98A 1997-09-30 1998-09-25 Thrombin inhibitors Ceased AU740170B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6053697P 1997-09-30 1997-09-30
US60/060536 1997-09-30
GBGB9806034.6A GB9806034D0 (en) 1998-03-20 1998-03-20 Thrombin inhibitors
GB9806034 1998-03-20
PCT/US1998/020174 WO1999016750A1 (fr) 1997-09-30 1998-09-25 Inhibiteurs de thrombine

Publications (2)

Publication Number Publication Date
AU9583998A AU9583998A (en) 1999-04-23
AU740170B2 true AU740170B2 (en) 2001-11-01

Family

ID=26313327

Family Applications (1)

Application Number Title Priority Date Filing Date
AU95839/98A Ceased AU740170B2 (en) 1997-09-30 1998-09-25 Thrombin inhibitors

Country Status (5)

Country Link
EP (1) EP1027333A4 (fr)
JP (1) JP2001518466A (fr)
AU (1) AU740170B2 (fr)
CA (1) CA2303832A1 (fr)
WO (1) WO1999016750A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19956786A1 (de) * 1999-11-25 2001-05-31 Basf Ag Verfahren zur Herstellung optisch aktiver Amine
US7857522B2 (en) * 2007-01-31 2010-12-28 Siemens Industry, Inc. Rolling mill oil film bearing

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240914A2 (fr) * 1986-04-01 1987-10-14 Wako Pure Chemical Industries, Ltd. Dérivés peptidiques et méthode de mesure de l'activité des substances physiologiquement actives utilisant ces substances comme substrats

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4306873A1 (de) * 1993-03-05 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Aminopyridine-Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
US5668289A (en) * 1996-06-24 1997-09-16 Merck & Co., Inc. Pyridinone thrombin inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240914A2 (fr) * 1986-04-01 1987-10-14 Wako Pure Chemical Industries, Ltd. Dérivés peptidiques et méthode de mesure de l'activité des substances physiologiquement actives utilisant ces substances comme substrats

Also Published As

Publication number Publication date
JP2001518466A (ja) 2001-10-16
EP1027333A4 (fr) 2000-11-08
EP1027333A1 (fr) 2000-08-16
CA2303832A1 (fr) 1999-04-08
WO1999016750A1 (fr) 1999-04-08
AU9583998A (en) 1999-04-23

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired