CA2302647A1 - Expression de gonadotrophines dans dictyostelium - Google Patents
Expression de gonadotrophines dans dictyostelium Download PDFInfo
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- CA2302647A1 CA2302647A1 CA002302647A CA2302647A CA2302647A1 CA 2302647 A1 CA2302647 A1 CA 2302647A1 CA 002302647 A CA002302647 A CA 002302647A CA 2302647 A CA2302647 A CA 2302647A CA 2302647 A1 CA2302647 A1 CA 2302647A1
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- Prior art keywords
- dictyostelium
- hcg
- gonadotropin
- gonadotropins
- expression
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- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 210000005059 placental tissue Anatomy 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108020003519 protein disulfide isomerase Proteins 0.000 description 1
- 108020001580 protein domains Proteins 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000027272 reproductive process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 125000005629 sialic acid group Chemical group 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne des gonadotrophines exprimées dans Dictyostelium. On a découvert que les gonadotrophines étaient sécrétées dans une forme active biologique. L'expression de gonadotrophines dans Dictyostelium constitue un moyen facile de sélection de mutants de gonadotrophines.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202757 | 1997-09-08 | ||
| EP97202757.7 | 1997-09-08 | ||
| PCT/EP1998/005717 WO1999013081A1 (fr) | 1997-09-08 | 1998-09-02 | EXPRESSION DE GONADOTROPHINES DANS $i(DICTYOSTELIUM) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2302647A1 true CA2302647A1 (fr) | 1999-03-18 |
Family
ID=8228713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002302647A Abandoned CA2302647A1 (fr) | 1997-09-08 | 1998-09-02 | Expression de gonadotrophines dans dictyostelium |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1012290A1 (fr) |
| JP (1) | JP2001515721A (fr) |
| KR (1) | KR20010023749A (fr) |
| CN (1) | CN1269834A (fr) |
| AR (1) | AR013468A1 (fr) |
| AU (1) | AU746780B2 (fr) |
| BR (1) | BR9812043A (fr) |
| CA (1) | CA2302647A1 (fr) |
| HU (1) | HUP0004599A3 (fr) |
| IL (1) | IL134589A0 (fr) |
| NO (1) | NO20001178L (fr) |
| NZ (1) | NZ502964A (fr) |
| PL (1) | PL339259A1 (fr) |
| TR (1) | TR200000618T2 (fr) |
| WO (1) | WO1999013081A1 (fr) |
| ZA (1) | ZA987497B (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014159813A1 (fr) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Molécules polynucléotidiques à longue durée de vie |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001058493A1 (fr) * | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
| AU2001267337A1 (en) * | 2000-06-30 | 2002-01-14 | Maxygen Aps | Peptide extended glycosylated polypeptides |
| KR20040032954A (ko) | 2001-09-12 | 2004-04-17 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 과배란 유도에서 ｈＣＧ의 용도 |
| IL160782A0 (en) * | 2001-09-12 | 2004-08-31 | Applied Research Systems | USE OF hCG IN THE MANUFACTURE OF A MEDICAMENT |
| AU2002324183B2 (en) * | 2001-09-12 | 2007-10-25 | Merck Serono Sa | Use of hCG and LH in controlled ovarian hyperstimulation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69534723T2 (de) * | 1994-02-18 | 2006-08-31 | Washington University | Einzelketten-Gonadotropin |
| US5691455A (en) * | 1995-10-24 | 1997-11-25 | Akzo Nobel N.V. | Gonadotropins with non-native disulfide bridges |
-
1998
- 1998-08-19 ZA ZA987497A patent/ZA987497B/xx unknown
- 1998-09-02 KR KR1020007002404A patent/KR20010023749A/ko not_active Application Discontinuation
- 1998-09-02 BR BR9812043-3A patent/BR9812043A/pt not_active IP Right Cessation
- 1998-09-02 NZ NZ502964A patent/NZ502964A/en unknown
- 1998-09-02 HU HU0004599A patent/HUP0004599A3/hu unknown
- 1998-09-02 JP JP2000510866A patent/JP2001515721A/ja not_active Withdrawn
- 1998-09-02 CN CN98808921A patent/CN1269834A/zh active Pending
- 1998-09-02 IL IL13458998A patent/IL134589A0/xx unknown
- 1998-09-02 CA CA002302647A patent/CA2302647A1/fr not_active Abandoned
- 1998-09-02 EP EP98948936A patent/EP1012290A1/fr not_active Withdrawn
- 1998-09-02 AU AU95381/98A patent/AU746780B2/en not_active Ceased
- 1998-09-02 PL PL98339259A patent/PL339259A1/xx not_active Application Discontinuation
- 1998-09-02 WO PCT/EP1998/005717 patent/WO1999013081A1/fr not_active Application Discontinuation
- 1998-09-02 TR TR2000/00618T patent/TR200000618T2/xx unknown
- 1998-09-07 AR ARP980104442A patent/AR013468A1/es unknown
-
2000
- 2000-03-07 NO NO20001178A patent/NO20001178L/no unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014159813A1 (fr) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Molécules polynucléotidiques à longue durée de vie |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20001178D0 (no) | 2000-03-07 |
| HUP0004599A3 (en) | 2002-09-30 |
| AR013468A1 (es) | 2000-12-27 |
| AU746780B2 (en) | 2002-05-02 |
| NZ502964A (en) | 2001-08-31 |
| JP2001515721A (ja) | 2001-09-25 |
| BR9812043A (pt) | 2000-10-03 |
| AU9538198A (en) | 1999-03-29 |
| IL134589A0 (en) | 2001-04-30 |
| KR20010023749A (ko) | 2001-03-26 |
| WO1999013081A1 (fr) | 1999-03-18 |
| CN1269834A (zh) | 2000-10-11 |
| EP1012290A1 (fr) | 2000-06-28 |
| NO20001178L (no) | 2000-05-05 |
| ZA987497B (en) | 1999-02-23 |
| PL339259A1 (en) | 2000-12-04 |
| HUP0004599A2 (hu) | 2001-04-28 |
| TR200000618T2 (tr) | 2000-09-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |