CA2302036C - Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice - Google Patents
Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice Download PDFInfo
- Publication number
- CA2302036C CA2302036C CA002302036A CA2302036A CA2302036C CA 2302036 C CA2302036 C CA 2302036C CA 002302036 A CA002302036 A CA 002302036A CA 2302036 A CA2302036 A CA 2302036A CA 2302036 C CA2302036 C CA 2302036C
- Authority
- CA
- Canada
- Prior art keywords
- matrix
- mass
- large organic
- organic molecule
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
Abstract
L'invention concerne un procédé de préparation d'échantillons en vue de la réalisation d'analyses de volatilisation et de spectrométrie de masse sur des molécules non volatiles à poids moléculaire élevé. Elle concerne également des molécules photo-absorbantes caractérisées par des vitesses de sublimation importantes à température de la pièce sous vide, lesquelles molécules, qui comportent, de préférence, des valences fonctionnelles hydroxy, sont destinées à être utilisées comme matrices pour la spectrométrie de masse à désorption/ionisation assistée par matrice. Les échantillons sont généralement refroidis dans le spectromètre de masse jusqu'à ce qu'ils atteignent des températures bien inférieures à la température de la pièce.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5093297P | 1997-05-30 | 1997-05-30 | |
US60/050,932 | 1997-05-30 | ||
PCT/US1998/011003 WO1998054751A1 (fr) | 1997-05-30 | 1998-05-29 | Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2302036A1 CA2302036A1 (fr) | 1998-12-03 |
CA2302036C true CA2302036C (fr) | 2003-09-02 |
Family
ID=21968407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002302036A Expired - Fee Related CA2302036C (fr) | 1997-05-30 | 1998-05-29 | Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0998749A1 (fr) |
AU (1) | AU7804098A (fr) |
CA (1) | CA2302036C (fr) |
WO (1) | WO1998054751A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
DE10050632A1 (de) * | 2000-10-12 | 2002-04-18 | Stiftung Caesar | Verfahren zum Nachweis biologischer Moleküle |
US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
WO2004060278A2 (fr) | 2002-12-06 | 2004-07-22 | Isis Pharmaceuticals, Inc. | Procedes d'identification rapide de pathogenes chez l'homme et les betes |
US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
US20040121309A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues |
US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US20120122099A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
EP2458619B1 (fr) | 2004-05-24 | 2017-08-02 | Ibis Biosciences, Inc. | Spectrométrie de masse avec filtration sélective d'ions par établissement de seuils numériques |
US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
WO2006135400A2 (fr) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Procedes pour l'identification rapide d'organismes recombinants |
US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
US20060205040A1 (en) | 2005-03-03 | 2006-09-14 | Rangarajan Sampath | Compositions for use in identification of adventitious viruses |
AU2006272776B2 (en) | 2005-07-21 | 2012-01-19 | Ibis Biosciences, Inc. | Methods for rapid identification and quantitation of nucleic acid variants |
US8088582B2 (en) | 2006-04-06 | 2012-01-03 | Ibis Biosciences, Inc. | Compositions for the use in identification of fungi |
AU2007353877B2 (en) | 2006-09-14 | 2012-07-19 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
JP5680304B2 (ja) | 2007-02-23 | 2015-03-04 | アイビス バイオサイエンシズ インコーポレイティッド | 迅速な法医学的dna分析法 |
WO2008151023A2 (fr) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Procédés et compositions pour l'amplification par déplacement multiple d'acides nucléiques |
EP2344893B1 (fr) | 2008-09-16 | 2014-10-15 | Ibis Biosciences, Inc. | Systèmes et procédés de manipulation de microplaques |
US8148163B2 (en) | 2008-09-16 | 2012-04-03 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
EP2349549B1 (fr) | 2008-09-16 | 2012-07-18 | Ibis Biosciences, Inc. | Cartouches de mélange, postes de mélange et kits, et système associé |
WO2010080616A1 (fr) | 2008-12-19 | 2010-07-15 | Abbott Laboratories | Dosage moléculaire pour le diagnostic du paludisme |
EP2396803A4 (fr) | 2009-02-12 | 2016-10-26 | Ibis Biosciences Inc | Ensembles sonde d'ionisation |
WO2010104798A1 (fr) | 2009-03-08 | 2010-09-16 | Ibis Biosciences, Inc. | Procédés de détection d'un bioagent |
US9393564B2 (en) | 2009-03-30 | 2016-07-19 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
US8950604B2 (en) | 2009-07-17 | 2015-02-10 | Ibis Biosciences, Inc. | Lift and mount apparatus |
WO2011008972A1 (fr) | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Systèmes pour l'identification d'un bioagent |
WO2011014811A1 (fr) | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Amorces de capture et supports solides liés à une séquence de capture pour tests diagnostiques moléculaires |
EP3098325A1 (fr) | 2009-08-06 | 2016-11-30 | Ibis Biosciences, Inc. | Compositions de base déterminée sans masse pour la détection d'acide nucléique |
ES2628739T3 (es) | 2009-10-15 | 2017-08-03 | Ibis Biosciences, Inc. | Amplificación por desplazamiento múltiple |
US9758840B2 (en) | 2010-03-14 | 2017-09-12 | Ibis Biosciences, Inc. | Parasite detection via endosymbiont detection |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4920264A (en) * | 1989-01-17 | 1990-04-24 | Sri International | Method for preparing samples for mass analysis by desorption from a frozen solution |
US5118937A (en) * | 1989-08-22 | 1992-06-02 | Finnigan Mat Gmbh | Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules |
US5135870A (en) * | 1990-06-01 | 1992-08-04 | Arizona Board Of Regents | Laser ablation/ionizaton and mass spectrometric analysis of massive polymers |
US5700642A (en) * | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
-
1998
- 1998-05-29 EP EP98926132A patent/EP0998749A1/fr not_active Withdrawn
- 1998-05-29 CA CA002302036A patent/CA2302036C/fr not_active Expired - Fee Related
- 1998-05-29 WO PCT/US1998/011003 patent/WO1998054751A1/fr active Application Filing
- 1998-05-29 AU AU78040/98A patent/AU7804098A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU7804098A (en) | 1998-12-30 |
WO1998054751A1 (fr) | 1998-12-03 |
EP0998749A1 (fr) | 2000-05-10 |
CA2302036A1 (fr) | 1998-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20160530 |