CA2301770A1 - Inhibiteurs de prenyl-proteine-transferases - Google Patents

Inhibiteurs de prenyl-proteine-transferases Download PDF

Info

Publication number
CA2301770A1
CA2301770A1 CA002301770A CA2301770A CA2301770A1 CA 2301770 A1 CA2301770 A1 CA 2301770A1 CA 002301770 A CA002301770 A CA 002301770A CA 2301770 A CA2301770 A CA 2301770A CA 2301770 A1 CA2301770 A1 CA 2301770A1
Authority
CA
Canada
Prior art keywords
cyanobenzyl
substituted
imidazol
alkyl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002301770A
Other languages
English (en)
Inventor
Christopher J. Dinsmore
John H. Hutchinson
Theresa M. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800975.6A external-priority patent/GB9800975D0/en
Application filed by Individual filed Critical Individual
Publication of CA2301770A1 publication Critical patent/CA2301770A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés qui inhibent les prényl-protéine-transférases, la farnésyl-protéine-transférase et la géranylgéranyl-protéine-transférase de type I, de même que la prénylation de la protéine oncogène Ras. L'invention concerne également des compositions chimiothérapeutiques renfermant les composés considérés, ainsi que des procédés permettant d'inhiber la farnésyl-protéine-transférase, la géranylgéranyl-protéine-transférase de type I et la prénylation de la protéine oncogène Ras.
CA002301770A 1997-08-27 1998-08-26 Inhibiteurs de prenyl-proteine-transferases Abandoned CA2301770A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5708097P 1997-08-27 1997-08-27
US60/057,080 1997-08-27
GBGB9800975.6A GB9800975D0 (en) 1998-01-16 1998-01-16 Inhibitors of prenyl-protein transferase
GB9800975.6 1998-01-16
PCT/US1998/017696 WO1999009985A1 (fr) 1997-08-27 1998-08-26 Inhibiteurs de prenyl-proteine-transferases

Publications (1)

Publication Number Publication Date
CA2301770A1 true CA2301770A1 (fr) 1999-03-04

Family

ID=26312960

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301770A Abandoned CA2301770A1 (fr) 1997-08-27 1998-08-26 Inhibiteurs de prenyl-proteine-transferases

Country Status (5)

Country Link
EP (1) EP1014984A1 (fr)
JP (1) JP2001513561A (fr)
AU (1) AU741725B2 (fr)
CA (1) CA2301770A1 (fr)
WO (1) WO1999009985A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562823B1 (en) 1998-07-02 2003-05-13 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
EP1158984A4 (fr) * 1998-10-29 2003-05-21 Merck & Co Inc Inhibiteurs de prenyl-proteine transferase
CA2362778A1 (fr) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibiteurs de prenyle proteine transferase
US6355643B1 (en) 1999-03-03 2002-03-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
CA2363169A1 (fr) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibiteurs de la prenyle-proteine transferase
US6358956B1 (en) 1999-03-03 2002-03-19 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
WO2001051125A1 (fr) 2000-01-12 2001-07-19 Merck & Co., Inc. Inhibiteurs de la prenyl-proteine transferase
US20020052380A1 (en) * 2000-02-18 2002-05-02 Dinsmore Christopher J. Inhibitors of prenyl-protein transferase
US6534506B2 (en) 2000-04-10 2003-03-18 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
AU2007229363B2 (en) * 2001-08-24 2009-06-04 University Of South Florida Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
US6593455B2 (en) 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
ATE530184T1 (de) * 2001-08-24 2011-11-15 Univ Yale Piperazinon-verbindungen als tumor- und krebsbekämpfende wirkstoffe
EP1436317A1 (fr) 2001-09-19 2004-07-14 Tripep Ab Molecules bloquant l'infectivite virale et methodes d'utilisation associees
EP1472222A1 (fr) 2002-02-08 2004-11-03 Glaxo Group Limited Derives piperidylcarboxamide, et leur utilisation dans le traitement des maladies dont la mediation est assuree par les tachykinines
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
JP4965130B2 (ja) * 2006-01-26 2012-07-04 日本臓器製薬株式会社 乾式直打速崩壊性錠剤
WO2015070367A1 (fr) * 2013-11-12 2015-05-21 Merck Sharp & Dohme Corp. Dérivés d'imidazole et de triazole liés à la pipéridine ou la pipérazine et leurs procédés d'utilisation pour améliorer la pharmacocinétique d'un médicament

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU706495B2 (en) * 1996-04-03 1999-06-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase

Also Published As

Publication number Publication date
EP1014984A1 (fr) 2000-07-05
WO1999009985A1 (fr) 1999-03-04
AU9121398A (en) 1999-03-16
JP2001513561A (ja) 2001-09-04
AU741725B2 (en) 2001-12-06

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Legal Events

Date Code Title Description
FZDE Dead