CA2301642A1 - Derives d'erythromycine 3-descladinose 6-o-substituee - Google Patents

Derives d'erythromycine 3-descladinose 6-o-substituee Download PDF

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Publication number
CA2301642A1
CA2301642A1 CA002301642A CA2301642A CA2301642A1 CA 2301642 A1 CA2301642 A1 CA 2301642A1 CA 002301642 A CA002301642 A CA 002301642A CA 2301642 A CA2301642 A CA 2301642A CA 2301642 A1 CA2301642 A1 CA 2301642A1
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CA
Canada
Prior art keywords
substituted
compound
formula
heteroaryl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002301642A
Other languages
English (en)
Inventor
Yat Sun Or
Leping Li
Michael J. Rupp
Daniel T. Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2301642A1 publication Critical patent/CA2301642A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés d'érythromycine multicycliques, ainsi que leurs sels et leurs esters pharmaceutiquement acceptables. Ces composés, qui présentent une activité bactéricide, sont représentés par une formule choisie dans le groupe composé par (I), (II), (III), (IV), et (V). L'invention concerne également des compositions renfermant une quantité thérapeutiquement efficace d'un composé de cette invention, associé à un excipient pharmaceutiquement acceptable. L'invention concerne enfin un procédé de traitement des infections bactériennes par administration à un mammifère d'une composition pharmaceutique renfermant une quantité thérapeutiquement efficace d'un composé des formules (I) à (V).
CA002301642A 1997-09-02 1998-09-01 Derives d'erythromycine 3-descladinose 6-o-substituee Abandoned CA2301642A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92168897A 1997-09-02 1997-09-02
US08/921,688 1997-09-02
PCT/US1998/018125 WO1999011651A2 (fr) 1997-09-02 1998-09-01 Derives d'erythromycine 3-descladinose 6-o-substituee

Publications (1)

Publication Number Publication Date
CA2301642A1 true CA2301642A1 (fr) 1999-03-11

Family

ID=25445830

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002301642A Abandoned CA2301642A1 (fr) 1997-09-02 1998-09-01 Derives d'erythromycine 3-descladinose 6-o-substituee

Country Status (9)

Country Link
EP (1) EP1027360A2 (fr)
JP (1) JP2001515844A (fr)
AR (1) AR017260A1 (fr)
AU (1) AU8925398A (fr)
CA (1) CA2301642A1 (fr)
CO (1) CO4960636A1 (fr)
SA (1) SA99191151A (fr)
WO (1) WO1999011651A2 (fr)
ZA (1) ZA987689B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9916969A (pt) 1999-01-27 2001-11-06 Pfizer Prod Inc Antibióticos cetólidos
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US20020115621A1 (en) 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
EP1310506A4 (fr) * 2000-08-14 2004-04-14 Taisho Pharmaceutical Co Ltd Procede servant a preparer un derive d'erythromycine
TWI246515B (en) * 2001-05-30 2006-01-01 Abbott Lab An arylation method for the functionalization of O-allyl erythromycin derivatives
WO2003102010A1 (fr) * 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. Agents antibacteriens macrolides 3-descladinosyl-6-o-carbamyle et 6-o-carbonyle
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
EA011281B1 (ru) 2004-12-21 2009-02-27 Пфайзер Продактс Инк. Макролиды
CN105418706B (zh) * 2015-10-27 2019-05-17 华南理工大学 一种大环内酯类抗菌化合物及其制备方法与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8506380D0 (en) * 1985-03-12 1985-04-11 Beecham Group Plc Chemical compounds
GB8521402D0 (en) * 1985-08-28 1985-10-02 Beecham Group Plc Chemical compounds
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0876388B1 (fr) * 1995-11-08 2004-02-18 Abbott Laboratories Derives tricycliques d'erythromycine
AU2340797A (en) * 1996-05-07 1997-11-26 Abbott Laboratories 6-o-substituted erythromycins and method for making them
JP2000198795A (ja) * 1996-10-31 2000-07-18 Taisho Pharmaceut Co Ltd エリスロマイシンａ誘導体
WO1998018808A1 (fr) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Derives de l'erythromycine

Also Published As

Publication number Publication date
AU8925398A (en) 1999-03-22
CO4960636A1 (es) 2000-09-25
ZA987689B (en) 1999-02-24
JP2001515844A (ja) 2001-09-25
SA99191151A (ar) 2005-12-03
WO1999011651A2 (fr) 1999-03-11
AR017260A1 (es) 2001-09-05
WO1999011651A3 (fr) 1999-05-06
EP1027360A2 (fr) 2000-08-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead