CA2299393A1 - Copolymeres blocs en gels injectables et biodegradables servant a administrer un medicament - Google Patents

Copolymeres blocs en gels injectables et biodegradables servant a administrer un medicament Download PDF

Info

Publication number
CA2299393A1
CA2299393A1 CA002299393A CA2299393A CA2299393A1 CA 2299393 A1 CA2299393 A1 CA 2299393A1 CA 002299393 A CA002299393 A CA 002299393A CA 2299393 A CA2299393 A CA 2299393A CA 2299393 A1 CA2299393 A1 CA 2299393A1
Authority
CA
Canada
Prior art keywords
poly
block
copolymer
block copolymer
polymer block
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002299393A
Other languages
English (en)
Inventor
Sung Wan Kim
Byeongmoon Jeong
You Han Bae
Doo Sung Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
Sung Wan Kim
University Of Utah Research Foundation
Byeongmoon Jeong
You Han Bae
Doo Sung Lee
University Of Utah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sung Wan Kim, University Of Utah Research Foundation, Byeongmoon Jeong, You Han Bae, Doo Sung Lee, University Of Utah filed Critical Sung Wan Kim
Publication of CA2299393A1 publication Critical patent/CA2299393A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
CA002299393A 1997-08-08 1998-08-08 Copolymeres blocs en gels injectables et biodegradables servant a administrer un medicament Abandoned CA2299393A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5517497P 1997-08-08 1997-08-08
US60/055,174 1997-08-08
US13096798A 1998-08-07 1998-08-07
US09/130,967 1998-08-07
PCT/US1998/016418 WO1999007343A1 (fr) 1997-08-08 1998-08-08 Copolymeres blocs en gels injectables et biodegradables servant a administrer un medicament

Publications (1)

Publication Number Publication Date
CA2299393A1 true CA2299393A1 (fr) 1999-02-18

Family

ID=26733929

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002299393A Abandoned CA2299393A1 (fr) 1997-08-08 1998-08-08 Copolymeres blocs en gels injectables et biodegradables servant a administrer un medicament

Country Status (5)

Country Link
EP (1) EP1024790A4 (fr)
JP (1) JP2001517603A (fr)
KR (1) KR20010022708A (fr)
CA (1) CA2299393A1 (fr)
WO (1) WO1999007343A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0986402A2 (fr) 1997-06-06 2000-03-22 Battelle Memorial Institute Copolymere a gelification reversible, et son procede d'obtention
AU736812B2 (en) * 1997-10-03 2001-08-02 Btg International Limited Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US7087244B2 (en) 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US6841617B2 (en) 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
EP1413296A1 (fr) * 1998-05-07 2004-04-28 ALZA Corporation Procédé de fabrication d'une forme galénique à bandes contenant des agents actifs à libération prolongée
US6245740B1 (en) * 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
WO2001041735A2 (fr) * 1999-12-07 2001-06-14 Amgen Inc. Hydrogels thermosensibles biodegradable a base de pluroniques de faible poids moleculaire
KR100358027B1 (ko) * 2000-02-14 2002-10-25 한국과학기술연구원 의료용 생분해성 삼중블록 공중합체 및 그의 제조 방법
CA2427543A1 (fr) 2000-03-15 2004-11-02 Yu-Ling Cheng Charge et implant a comportement thermique reversible
US7193007B2 (en) 2000-03-15 2007-03-20 Yu-Ling Cheng Environment responsive gelling copolymer
AU2001242144A1 (en) * 2000-03-15 2001-09-24 Yu-Ling Cheng Environment responsive gelling copolymer
KR100418916B1 (ko) * 2000-11-28 2004-02-14 한국과학기술원 생분해성 고분자와 항암제의 접합체를 이용한 서방형미셀제제의 제조방법
US8263664B2 (en) 2002-05-19 2012-09-11 University Of Utah Research Foundation pH-sensitive polymeric micelles for drug delivery
US7229973B2 (en) * 2002-05-19 2007-06-12 You Han Bae pH-sensitive polymeric micelles for drug delivery
US7659314B2 (en) 2002-05-19 2010-02-09 University Of Utah Research Foundation PH-sensitive polymeric micelles for drug delivery
EP1687378B1 (fr) 2003-11-04 2014-01-08 SupraPolix B.V. Preparation de polymeres supramoleculaires contenant des unites de liaison hydrogene quadruples dans le squelette polymere
EP1773903B1 (fr) 2004-07-12 2017-08-09 SupraPolix B.V. Ionomeres supramoleculaires
US8357391B2 (en) * 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
EP1807018A4 (fr) 2004-10-21 2012-07-04 Univ Iowa Res Found Systeme d'administration in situ de medicaments a liberation controlee
ES2376888T3 (es) 2005-05-04 2012-03-20 Suprapolix B.V. Materiales supramoleculares activos biológicamente, modulares biorreabsorbibles o biomédicos
ATE512200T1 (de) 2005-05-04 2011-06-15 Suprapolix Bv Hydrogele mit wasserstoffbrückenbindungen
US20100076147A1 (en) 2006-11-20 2010-03-25 Suprapolix B.V. Supramolecular polymers from low-melting, easily processable building blocks
US8628789B2 (en) 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
EP2343342B1 (fr) 2007-03-23 2015-09-16 SupraPolix B.V. Hydrogels fortement réversibles
KR100838809B1 (ko) * 2007-05-03 2008-06-17 성균관대학교산학협력단 겔강도가 우수한 온도 및 피에치 민감성 블록 공중합체 및이의 제조방법과 이를 이용한 약물전달체
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
KR100951554B1 (ko) 2008-06-04 2010-04-09 아주대학교산학협력단 마이셀 형성 및 약물 방출 제어가 가능한 6-팔ｐｌｌａ-ｐｅｇ 블록 공중합체
EP2310376B1 (fr) 2008-07-04 2014-11-05 SupraPolix B.V. Composés supra-moléculaires à haut débit
US9006386B2 (en) 2010-11-05 2015-04-14 Suprapolix B.V. Process for the preparation of a supramolecular polymer
CN104758256B (zh) * 2014-02-14 2016-05-04 苏州海特比奥生物技术有限公司 一种多西他赛纳米聚合物胶束冻干制剂及其制备方法
US10358521B2 (en) 2014-07-28 2019-07-23 Suprapolix B.V. Durable hydrogen bonded hydrogels
JP6886402B2 (ja) * 2015-08-24 2021-06-16 株式会社スリー・ディー・マトリックス 生分解性インジェクタブルゲル
WO2018039318A1 (fr) * 2016-08-26 2018-03-01 Akina, Inc. Formulations de polymère biodégradable pour prolonger l'efficacité de la toxine botulique.
US11666527B2 (en) 2017-07-17 2023-06-06 Medincell Biodegradable block copolymer drug delivery composition
CN110156971A (zh) * 2018-02-13 2019-08-23 上海时莱生物技术有限公司 一种两亲性嵌段共聚物及其制备方法和纳米胶束载药系统
FI129022B (en) * 2019-09-10 2021-05-14 Aabo Akademi Univ Polymer and composition made from a renewable source
US20220331240A1 (en) * 2019-09-13 2022-10-20 Medincell S.A. Drug delivery formulations
EP4014963A1 (fr) * 2020-12-16 2022-06-22 Medincell Composition pharmaceutique

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US5306501A (en) * 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
KR960015447B1 (ko) * 1993-03-16 1996-11-14 주식회사 삼양사 의료용 생분해성 고분자
EP0717999A1 (fr) * 1994-12-19 1996-06-26 The University Of Miami Composition pour délivrer un médicament
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법

Also Published As

Publication number Publication date
EP1024790A1 (fr) 2000-08-09
JP2001517603A (ja) 2001-10-09
EP1024790A4 (fr) 2000-10-25
KR20010022708A (ko) 2001-03-26
WO1999007343A1 (fr) 1999-02-18

Similar Documents

Publication Publication Date Title
CA2299393A1 (fr) Copolymeres blocs en gels injectables et biodegradables servant a administrer un medicament
AU2001294828B2 (en) Thermogelling biodegradable aqueous polymer solution
US6984393B2 (en) Biodegradable elastomer and method of preparing same
CA2305621C (fr) Copolymeres trisequences de poly(lactide-co-glycolide) polyethylene-glycol, de faible poids moleculaire, biodegradables dotes de caracteristiques de gelification thermique inverses
AU758475B2 (en) Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties
US9265836B2 (en) Biodegradable block copolymeric compositions for drug delivery
AU763154B2 (en) Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof
US6004573A (en) Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US7087244B2 (en) Thermogelling oligopeptide polymers
AU605172B2 (en) Polyesters containing alkylene oxide blocks as drug delivery systems
US20060034889A1 (en) Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
ZA200102453B (en) Biodegradable low molecular weight triblock polyester polythylene glycol copolymers having reverse thermal gelation properties.
WO1997015287A1 (fr) Polymeres biodegradables thermosensible a base de copolymeres a sequence poly(ether-ester)
US7740877B2 (en) Aliphatically modified biodegradable block copolymers as thermogelling polymers
KR20120062511A (ko) 생체접착성이 우수한 온도 및 피에이치 민감성 스타형 블록 공중합체 및 이의 제조방법 그리고 이를 이용한 주사형 하이드로젤 약물전달체
EP1865988A2 (fr) Copolymeres dibloc et tribloc de polyethyleneglycol-polyacetal et compositions pharmaceutiques associees
CA2235413C (fr) Polymeres biodegradables thermosensible a base de copolymeres a sequence poly(ether-ester)

Legal Events

Date Code Title Description
FZDE Dead