CA2299345A1 - Multi parameter scanner - Google Patents
Multi parameter scanner Download PDFInfo
- Publication number
- CA2299345A1 CA2299345A1 CA002299345A CA2299345A CA2299345A1 CA 2299345 A1 CA2299345 A1 CA 2299345A1 CA 002299345 A CA002299345 A CA 002299345A CA 2299345 A CA2299345 A CA 2299345A CA 2299345 A1 CA2299345 A1 CA 2299345A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- scanner
- radiation
- wavelength
- coupled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000001514 detection method Methods 0.000 claims abstract description 52
- 230000005284 excitation Effects 0.000 claims abstract description 31
- 230000003287 optical effect Effects 0.000 claims abstract description 27
- 239000000523 sample Substances 0.000 claims description 120
- 239000000835 fiber Substances 0.000 claims description 71
- 230000005855 radiation Effects 0.000 claims description 45
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 42
- 238000013519 translation Methods 0.000 claims description 34
- 230000008878 coupling Effects 0.000 claims description 16
- 238000010168 coupling process Methods 0.000 claims description 16
- 238000005859 coupling reaction Methods 0.000 claims description 16
- 239000013307 optical fiber Substances 0.000 claims description 14
- 239000000499 gel Substances 0.000 claims description 9
- 238000012544 monitoring process Methods 0.000 claims description 4
- 238000005457 optimization Methods 0.000 claims description 4
- 238000003491 array Methods 0.000 claims description 3
- 238000012163 sequencing technique Methods 0.000 claims description 3
- 238000009396 hybridization Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000011546 protein dye Substances 0.000 claims description 2
- 238000005286 illumination Methods 0.000 claims 11
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 17
- 102000004190 Enzymes Human genes 0.000 abstract description 5
- 108090000790 Enzymes Proteins 0.000 abstract description 5
- 238000012546 transfer Methods 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 238000004476 mid-IR spectroscopy Methods 0.000 abstract description 2
- 239000000975 dye Substances 0.000 description 8
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 6
- 239000007850 fluorescent dye Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 230000009977 dual effect Effects 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- -1 Bodipy Chemical compound 0.000 description 3
- 229910052786 argon Inorganic materials 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 238000001917 fluorescence detection Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- MZZINWWGSYUHGU-UHFFFAOYSA-J ToTo-1 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3S2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2S1 MZZINWWGSYUHGU-UHFFFAOYSA-J 0.000 description 2
- GRRMZXFOOGQMFA-UHFFFAOYSA-J YoYo-1 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3O2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2O1 GRRMZXFOOGQMFA-UHFFFAOYSA-J 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 239000005350 fused silica glass Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229910052743 krypton Inorganic materials 0.000 description 2
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- VOFUROIFQGPCGE-UHFFFAOYSA-N nile red Chemical compound C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=O)C2=C1 VOFUROIFQGPCGE-UHFFFAOYSA-N 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- VGIRNWJSIRVFRT-UHFFFAOYSA-N 2',7'-difluorofluorescein Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(F)C(=O)C=C2OC2=CC(O)=C(F)C=C21 VGIRNWJSIRVFRT-UHFFFAOYSA-N 0.000 description 1
- WORLWSFCGZCFSW-UHFFFAOYSA-N 6-[2-[3-(3-ethyl-1,3-benzoxazol-2-ylidene)prop-1-enyl]-1,3-benzoxazol-3-ium-3-yl]hexanoate Chemical compound O1C2=CC=CC=C2[N+](CCCCCC([O-])=O)=C1\C=C\C=C1/N(CC)C2=CC=CC=C2O1 WORLWSFCGZCFSW-UHFFFAOYSA-N 0.000 description 1
- DJFNQJJTTPMBIL-UHFFFAOYSA-N 7-nitrobenzoxadiazole-6-aminohexanoic acid Chemical compound OC(=O)CCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C12 DJFNQJJTTPMBIL-UHFFFAOYSA-N 0.000 description 1
- 230000007023 DNA restriction-modification system Effects 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- GYPIAQJSRPTNTI-UHFFFAOYSA-J PoPo-3 Chemical compound [I-].[I-].[I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=CC=C1C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN2C=CC(=CC=CC3=[N+](C4=CC=CC=C4O3)C)C=C2)C=C1 GYPIAQJSRPTNTI-UHFFFAOYSA-J 0.000 description 1
- CGNLCCVKSWNSDG-UHFFFAOYSA-N SYBR Green I Chemical compound CN(C)CCCN(CCC)C1=CC(C=C2N(C3=CC=CC=C3S2)C)=C2C=CC=CC2=[N+]1C1=CC=CC=C1 CGNLCCVKSWNSDG-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- GTSMOYLSFUBTMV-UHFFFAOYSA-N ethidium homodimer Chemical compound [H+].[H+].[Cl-].[Cl-].[Cl-].[Cl-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2C(C)=[N+]1CCCNCCNCCC[N+](C1=CC(N)=CC=C1C1=CC=C(N)C=C11)=C1C1=CC=CC=C1 GTSMOYLSFUBTMV-UHFFFAOYSA-N 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- XJENLUNLXRJLEZ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=C(C)C(N(CC)CC)=CC2=[O+]C=2C=C(N(CC)CC)C(C)=CC=2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O XJENLUNLXRJLEZ-UHFFFAOYSA-M 0.000 description 1
- DLBFLQKQABVKGT-UHFFFAOYSA-L lucifer yellow dye Chemical compound [Li+].[Li+].[O-]S(=O)(=O)C1=CC(C(N(C(=O)NN)C2=O)=O)=C3C2=CC(S([O-])(=O)=O)=CC3=C1N DLBFLQKQABVKGT-UHFFFAOYSA-L 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
- JGVWCANSWKRBCS-UHFFFAOYSA-N tetramethylrhodamine thiocyanate Chemical compound [Cl-].C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=C(SC#N)C=C1C(O)=O JGVWCANSWKRBCS-UHFFFAOYSA-N 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B42/00—Obtaining records using waves other than optical waves; Visualisation of such records by using optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6471—Special filters, filter wheel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/024—Modular construction
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5556797P | 1997-08-13 | 1997-08-13 | |
| US60/055,567 | 1997-08-13 | ||
| US09/001,254 | 1997-12-30 | ||
| US09/001,254 US6043506A (en) | 1997-08-13 | 1997-12-30 | Multi parameter scanner |
| PCT/US1998/016680 WO1999009455A1 (en) | 1997-08-13 | 1998-08-11 | Multi parameter scanner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2299345A1 true CA2299345A1 (en) | 1999-02-25 |
Family
ID=26668772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002299345A Abandoned CA2299345A1 (en) | 1997-08-13 | 1998-08-11 | Multi parameter scanner |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6043506A (https=) |
| EP (1) | EP1004056A4 (https=) |
| JP (2) | JP2001516036A (https=) |
| CA (1) | CA2299345A1 (https=) |
| WO (1) | WO1999009455A1 (https=) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6597450B1 (en) * | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays |
| JPH1198372A (ja) * | 1997-09-18 | 1999-04-09 | Olympus Optical Co Ltd | 色調整方法 |
| JP3333449B2 (ja) * | 1998-04-30 | 2002-10-15 | 富士写真フイルム株式会社 | 画像読み取り装置 |
| US6528801B1 (en) * | 1998-11-04 | 2003-03-04 | The Research Foundation Of State University Of New York | Method and apparatus for detecting radiation |
| US6320196B1 (en) * | 1999-01-28 | 2001-11-20 | Agilent Technologies, Inc. | Multichannel high dynamic range scanner |
| US20050279949A1 (en) | 1999-05-17 | 2005-12-22 | Applera Corporation | Temperature control for light-emitting diode stabilization |
| US6518068B1 (en) * | 1999-07-21 | 2003-02-11 | Tropix, Inc. | Luminescence detection workstation |
| US6411373B1 (en) | 1999-10-08 | 2002-06-25 | Instrumentation Metrics, Inc. | Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis |
| US6814933B2 (en) * | 2000-09-19 | 2004-11-09 | Aurora Biosciences Corporation | Multiwell scanner and scanning method |
| US6586257B1 (en) * | 1999-10-12 | 2003-07-01 | Vertex Pharmaceuticals Incorporated | Multiwell scanner and scanning method |
| US6448089B1 (en) * | 1999-10-12 | 2002-09-10 | Aurora Biosciences Corporation | Multiwell scanner and scanning method |
| US6775567B2 (en) * | 2000-02-25 | 2004-08-10 | Xenogen Corporation | Imaging apparatus |
| US6563581B1 (en) * | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
| US6495812B1 (en) | 2000-08-02 | 2002-12-17 | Li-Cor, Inc. | Apparatus and method for analyzing an object of interest having a pivotably movable source and detector |
| JP4282251B2 (ja) * | 2000-08-02 | 2009-06-17 | 富士フイルム株式会社 | 生化学解析用ユニットおよびそれを用いた生化学解析方法 |
| JP3903102B2 (ja) * | 2000-08-18 | 2007-04-11 | 富士フイルム株式会社 | 画像情報読取装置 |
| KR100371560B1 (ko) * | 2000-12-14 | 2003-02-07 | 주식회사 디지탈바이오테크놀러지 | 유전자 판독기 |
| EP1245946B1 (en) * | 2001-03-28 | 2004-09-29 | Agilent Technologies Inc. a Delaware Corporation | Improved apparatus and method for absorbance detection |
| US20040130704A1 (en) * | 2001-04-05 | 2004-07-08 | Josef Beller | Optical property determination using differences in signal responses to applied modulated laser signals |
| US7348587B2 (en) * | 2001-06-28 | 2008-03-25 | Fujifilm Corporation | Method for producing biochemical analysis data and apparatus used therefor |
| US6995841B2 (en) * | 2001-08-28 | 2006-02-07 | Rice University | Pulsed-multiline excitation for color-blind fluorescence detection |
| US6750457B2 (en) * | 2001-08-29 | 2004-06-15 | Becton Dickinson And Company | System for high throughput analysis |
| GB0128587D0 (en) * | 2001-11-29 | 2002-01-23 | Amersham Pharm Biotech Uk Ltd | Dynamic range |
| US6922246B2 (en) * | 2002-02-22 | 2005-07-26 | Xenogen Corporation | Bottom fluorescence illumination assembly for an imaging apparatus |
| US7474399B2 (en) * | 2002-02-22 | 2009-01-06 | Xenogen Corporation | Dual illumination system for an imaging apparatus and method |
| US7474398B2 (en) * | 2002-02-22 | 2009-01-06 | Xenogen Corporation | Illumination system for an imaging apparatus with low profile output device |
| KR100482821B1 (ko) * | 2002-03-22 | 2005-04-14 | (주) 엠아이알 | 형광 이미지 저장 스크린 판독장치 및 방법 |
| US7061616B2 (en) * | 2002-03-28 | 2006-06-13 | Samsung Electronics Co., Ltd. | Optical transceiver and method for image density measurement |
| US20040072274A1 (en) * | 2002-05-09 | 2004-04-15 | Lebrun Stewart J. | System and method for visualization and digital analysis of protein and other macromolecule microarrays |
| EP2775291B1 (en) * | 2002-05-17 | 2016-01-13 | Life Technologies Corporation | Apparatus for differentiating multiple fluorescence signals by excitation wavelength |
| US20040027659A1 (en) * | 2002-08-08 | 2004-02-12 | Messerschmidt Robert G. | Sample holder |
| CA2446368C (en) * | 2002-10-29 | 2014-10-14 | Bayer Healthcare Llc | Diffuse reflectance readhead |
| US20040095615A1 (en) * | 2002-11-14 | 2004-05-20 | Chung-Hua Tsai | Biological scanner with two dimensional scanning operation |
| US20040155202A1 (en) * | 2002-11-21 | 2004-08-12 | Cdex, Inc. | Methods and apparatus for molecular species detection, inspection and classification using ultraviolet fluorescence |
| US6934030B2 (en) * | 2002-12-18 | 2005-08-23 | The Research Foundation Of State University Of New York | Method and apparatus for detecting radiation |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| EP1646862B1 (en) * | 2003-06-03 | 2018-04-11 | Siemens Healthcare Diagnostics Inc. | Automatic identification of reagent test strips using reflectance values |
| DE10325735B4 (de) * | 2003-06-06 | 2006-06-29 | Robert Bosch Gmbh | Vorrichtung und Verfahren zur Analyse einer Materialbibliothek |
| ES2244296B1 (es) * | 2003-10-03 | 2007-02-01 | Signe, S.A. | Sistema de medicion de fosforo y procedimiento asociado. |
| US7295316B2 (en) * | 2004-01-14 | 2007-11-13 | Applera Corporation | Fluorescent detector with automatic changing filters |
| JP4170947B2 (ja) * | 2004-04-09 | 2008-10-22 | 株式会社日立ハイテクノロジーズ | 生体試料成分検出法及びその装置 |
| JP4739190B2 (ja) * | 2004-04-30 | 2011-08-03 | プレシジョン・システム・サイエンス株式会社 | 光情報読取装置 |
| DE102004022263A1 (de) * | 2004-05-06 | 2005-12-15 | Clondiag Chip Technologies Gmbh | Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen |
| EP1610091A1 (de) * | 2004-06-23 | 2005-12-28 | Leica Geosystems AG | Scannersystem und Verfahren zur Erfassung von Oberflächen |
| US8552401B2 (en) * | 2005-04-25 | 2013-10-08 | Polestar Technologies, Inc. | Optical chemical sensor feedback control system |
| US20060237664A1 (en) * | 2005-04-25 | 2006-10-26 | Polestar Technologies, Inc. | Feedback control system |
| JP2008544254A (ja) * | 2005-06-13 | 2008-12-04 | ストラタジーン カリフォルニア | 別個の光学経路を有している蛍光の励起および検出のためのシステムおよび方法 |
| US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
| US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
| JP2007147584A (ja) * | 2005-10-28 | 2007-06-14 | Fujifilm Corp | 放射線画像変換パネルおよび放射線画像取得システム |
| US20070098594A1 (en) * | 2005-11-03 | 2007-05-03 | Roche Molecular Systems, Inc. | Analytical multi-spectral optical detection system |
| US7329860B2 (en) | 2005-11-23 | 2008-02-12 | Illumina, Inc. | Confocal imaging methods and apparatus |
| US20070178480A1 (en) * | 2006-01-31 | 2007-08-02 | Corson John F | Extended dynamic range reading of chemical arrays |
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1997
- 1997-12-30 US US09/001,254 patent/US6043506A/en not_active Expired - Lifetime
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1998
- 1998-08-11 EP EP98939349A patent/EP1004056A4/en not_active Withdrawn
- 1998-08-11 JP JP2000510061A patent/JP2001516036A/ja not_active Withdrawn
- 1998-08-11 WO PCT/US1998/016680 patent/WO1999009455A1/en not_active Ceased
- 1998-08-11 CA CA002299345A patent/CA2299345A1/en not_active Abandoned
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2004
- 2004-06-07 JP JP2004168607A patent/JP2004264312A/ja active Pending
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| Publication number | Publication date |
|---|---|
| JP2004264312A (ja) | 2004-09-24 |
| US6043506A (en) | 2000-03-28 |
| EP1004056A1 (en) | 2000-05-31 |
| WO1999009455A1 (en) | 1999-02-25 |
| JP2001516036A (ja) | 2001-09-25 |
| EP1004056A4 (en) | 2001-08-16 |
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