CA2292608A1 - Therapeutic systems for activation prodrugs - Google Patents
Therapeutic systems for activation prodrugs Download PDFInfo
- Publication number
- CA2292608A1 CA2292608A1 CA002292608A CA2292608A CA2292608A1 CA 2292608 A1 CA2292608 A1 CA 2292608A1 CA 002292608 A CA002292608 A CA 002292608A CA 2292608 A CA2292608 A CA 2292608A CA 2292608 A1 CA2292608 A1 CA 2292608A1
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- Prior art keywords
- nqo2
- target cell
- prodrug
- nrh
- patient
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9712370.7A GB9712370D0 (en) | 1997-06-14 | 1997-06-14 | Therapeutic systems |
| GB9712370.7 | 1997-06-14 | ||
| PCT/GB1998/001731 WO1998057662A2 (en) | 1997-06-14 | 1998-06-15 | Therapeutic systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2292608A1 true CA2292608A1 (en) | 1998-12-23 |
Family
ID=10814135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002292608A Abandoned CA2292608A1 (en) | 1997-06-14 | 1998-06-15 | Therapeutic systems for activation prodrugs |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US6867231B1 (enExample) |
| EP (2) | EP1468698A3 (enExample) |
| JP (1) | JP4272263B2 (enExample) |
| AT (1) | ATE311905T1 (enExample) |
| CA (1) | CA2292608A1 (enExample) |
| CY (1) | CY1105424T1 (enExample) |
| DE (1) | DE69832702T2 (enExample) |
| DK (1) | DK0988059T3 (enExample) |
| ES (1) | ES2257810T3 (enExample) |
| GB (2) | GB9712370D0 (enExample) |
| HK (1) | HK1041824B (enExample) |
| WO (1) | WO1998057662A2 (enExample) |
Families Citing this family (24)
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| GB9712370D0 (en) * | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
| GB9903019D0 (en) * | 1999-02-10 | 1999-03-31 | Microbiological Res Authority | Nitroreductase enzymes |
| EP1210358A4 (en) * | 1999-08-13 | 2005-01-05 | Univ Brandeis | DETECTION OF NUCLEIC ACIDS |
| CN1315529A (zh) * | 2000-03-29 | 2001-10-03 | 上海博德基因开发有限公司 | 一种新的多肽——人醌蛋白还原酶9和编码这种多肽的多核苷酸 |
| EP1432815A4 (en) * | 2001-09-14 | 2006-02-22 | Univ Duke | QUINONE REDUCTASE 2 AND ALDEHYDE DESHYDROGENASE USED AS THERAPEUTIC TARGETS |
| GB0328314D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Bath | Therapeutics |
| CA2555675A1 (en) * | 2004-02-10 | 2005-08-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
| US8114626B2 (en) * | 2004-02-10 | 2012-02-14 | Trustees Of Dartmouth College | Yeast strain and method for using the same to produce nicotinamide riboside |
| JP4823894B2 (ja) | 2004-04-09 | 2011-11-24 | 中外製薬株式会社 | 新規水溶性プロドラッグ |
| US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| CA2610854A1 (en) * | 2005-03-30 | 2006-10-05 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| US20060292099A1 (en) * | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
| TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| GB0517957D0 (en) | 2005-09-03 | 2005-10-12 | Morvus Technology Ltd | Method of combating infection |
| GB0526552D0 (en) | 2005-12-29 | 2006-02-08 | Morvus Technology Ltd | New use |
| GB2442202A (en) | 2006-09-30 | 2008-04-02 | Morvus Technology Ltd | Vermin poison |
| CA2956163C (en) | 2014-07-24 | 2023-01-10 | W.R. Grace & Co.-Conn. | Crystalline form of nicotinamide riboside |
| CN107428791B (zh) | 2015-03-09 | 2024-05-28 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| KR102426320B1 (ko) * | 2015-03-16 | 2022-07-29 | 크로마덱스 아이엔씨. | 니코틴산 리보사이드 또는 니코틴아미드 리보사이드 조성물, 이의 환원 유도체, 및 이의 용도 |
| US10392414B2 (en) * | 2015-07-15 | 2019-08-27 | Cornell University | Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives |
| CN120383644A (zh) | 2016-11-11 | 2025-07-29 | 英国贝尔法斯特女王大学 | 烟酰基核苷和还原的烟酰基核苷、其改性衍生物、磷酸化的类似物、腺苷二核苷酸共轭物、以及新颖结晶形式的有效且可规模化的合成 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| AU2017367092B2 (en) | 2016-11-29 | 2022-11-03 | University Of Iowa Research Foundation | Use of NAD precursors for improving maternal health and/or offspring health |
| CA3086535A1 (en) | 2017-12-22 | 2019-06-27 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
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| US440859A (en) * | 1890-11-18 | Wire-rope machine | ||
| US4440859A (en) | 1977-05-27 | 1984-04-03 | The Regents Of The University Of California | Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms |
| JPS5460386A (en) * | 1977-10-20 | 1979-05-15 | Fuji Photo Film Co Ltd | Photopolymerizable composition |
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| IN151589B (enExample) | 1978-12-22 | 1983-05-28 | Biogen Nv | |
| US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4678751A (en) | 1981-09-25 | 1987-07-07 | Genentech, Inc. | Hybrid human leukocyte interferons |
| US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US5087618A (en) * | 1982-05-18 | 1992-02-11 | University Of Florida | Redox carriers for brain-specific drug delivery |
| US4582800A (en) | 1982-07-12 | 1986-04-15 | Hoffmann-La Roche Inc. | Novel vectors and method for controlling interferon expression |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| JPS60184252A (ja) * | 1984-03-02 | 1985-09-19 | Canon Inc | 電子写真感光体 |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| GB8615701D0 (en) | 1986-06-27 | 1986-08-06 | Delta Biotechnology Ltd | Stable gene integration vector |
| GB8620926D0 (en) | 1986-08-29 | 1986-10-08 | Delta Biotechnology Ltd | Yeast promoter |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| NZ225599A (en) | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| GB8809616D0 (en) | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
| DE68925893T2 (de) | 1988-07-23 | 1996-08-08 | Delta Biotechnology Ltd | Sekretorische leader-sequenzen |
| GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
| GB8929097D0 (en) | 1989-12-22 | 1990-02-28 | Imp Cancer Res Tech | Mucin nucleotides |
| GB9001641D0 (en) | 1990-01-24 | 1990-03-21 | Imp Cancer Res Tech | Compounds |
| US5633158A (en) * | 1991-10-23 | 1997-05-27 | Cancer Research Campaign Technology Limited | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form |
| GB9200417D0 (en) | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Cytotoxic drug therapy |
| GB9200415D0 (en) | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Inactivation of cytotoxic drugs |
| GB9323008D0 (en) * | 1993-11-05 | 1994-01-05 | Connors Thomas | Improvements relating to cancer therapy |
| GB9516943D0 (en) * | 1995-08-18 | 1995-10-18 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs |
| GB9524942D0 (en) | 1995-12-06 | 1996-02-07 | Aepact Ltd | Drug therapy |
| WO1997024143A1 (en) | 1995-12-29 | 1997-07-10 | Aepact Limited | Cytotoxic agents |
| WO1998022577A1 (en) * | 1996-11-15 | 1998-05-28 | Maria Grazia Masucci | Fusion proteins having increased half-lives |
| GB9624993D0 (en) | 1996-11-30 | 1997-01-15 | Aepact Ltd | Tumour therapy |
| GB9712370D0 (en) * | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
-
1997
- 1997-06-14 GB GBGB9712370.7A patent/GB9712370D0/en active Pending
-
1998
- 1998-06-15 DE DE69832702T patent/DE69832702T2/de not_active Expired - Fee Related
- 1998-06-15 WO PCT/GB1998/001731 patent/WO1998057662A2/en not_active Ceased
- 1998-06-15 EP EP04076964A patent/EP1468698A3/en not_active Withdrawn
- 1998-06-15 DK DK98929555T patent/DK0988059T3/da active
- 1998-06-15 GB GB9928237A patent/GB2341605B/en not_active Expired - Fee Related
- 1998-06-15 US US09/445,865 patent/US6867231B1/en not_active Expired - Fee Related
- 1998-06-15 AT AT98929555T patent/ATE311905T1/de not_active IP Right Cessation
- 1998-06-15 ES ES98929555T patent/ES2257810T3/es not_active Expired - Lifetime
- 1998-06-15 JP JP50395399A patent/JP4272263B2/ja not_active Expired - Fee Related
- 1998-06-15 EP EP98929555A patent/EP0988059B8/en not_active Expired - Lifetime
- 1998-06-15 CA CA002292608A patent/CA2292608A1/en not_active Abandoned
-
2000
- 2000-04-13 HK HK02103701.2A patent/HK1041824B/zh not_active IP Right Cessation
-
2002
- 2002-03-13 US US10/099,830 patent/US7138122B2/en not_active Expired - Fee Related
-
2006
- 2006-03-07 CY CY20061100305T patent/CY1105424T1/el unknown
- 2006-11-09 US US11/558,042 patent/US20070166296A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB9712370D0 (en) | 1997-08-13 |
| WO1998057662A3 (en) | 1999-08-12 |
| WO1998057662A2 (en) | 1998-12-23 |
| HK1023069A1 (en) | 2000-09-01 |
| HK1041824A1 (en) | 2002-07-26 |
| GB2341605A (en) | 2000-03-22 |
| ES2257810T3 (es) | 2006-08-01 |
| DE69832702T2 (de) | 2006-08-10 |
| EP0988059B1 (en) | 2005-12-07 |
| GB9928237D0 (en) | 2000-01-26 |
| GB2341605A8 (en) | 2000-03-28 |
| EP0988059B8 (en) | 2006-03-01 |
| HK1041824B (zh) | 2002-11-15 |
| ATE311905T1 (de) | 2005-12-15 |
| DE69832702D1 (de) | 2006-01-12 |
| EP0988059A2 (en) | 2000-03-29 |
| EP1468698A2 (en) | 2004-10-20 |
| GB2341605B (en) | 2002-02-20 |
| US20070166296A1 (en) | 2007-07-19 |
| JP4272263B2 (ja) | 2009-06-03 |
| JP2002511754A (ja) | 2002-04-16 |
| US6867231B1 (en) | 2005-03-15 |
| DK0988059T3 (da) | 2006-01-23 |
| EP1468698A3 (en) | 2005-03-23 |
| US7138122B2 (en) | 2006-11-21 |
| CY1105424T1 (el) | 2010-04-28 |
| US20030086933A1 (en) | 2003-05-08 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |