CA2289727A1 - Proteines sm1 presentes a la surface des cellules hematopoietiques souches - Google Patents

Proteines sm1 presentes a la surface des cellules hematopoietiques souches Download PDF

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Publication number
CA2289727A1
CA2289727A1 CA002289727A CA2289727A CA2289727A1 CA 2289727 A1 CA2289727 A1 CA 2289727A1 CA 002289727 A CA002289727 A CA 002289727A CA 2289727 A CA2289727 A CA 2289727A CA 2289727 A1 CA2289727 A1 CA 2289727A1
Authority
CA
Canada
Prior art keywords
cells
antibody
protein
hematopoietic stem
hematopoietic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002289727A
Other languages
English (en)
Inventor
Peter M.C. Wong
Siu-Wah Chung
Xiaodong Han
Hong Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stemcell Therapeutics LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2289727A1 publication Critical patent/CA2289727A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur une protéine dite "SM1" d'un poids moléculaire de 230 kDa mesuré par immunoprécipitation et SDS-PAGE. Les protéines SM1 sont présentes à la surface des cellules hématopoïétiques souches de l'homme et de la souris, et sur les cellules ascendantes primitives, mais absentes de la surface des autres cellules telles que les cellules ascendantes FDC-P1 du myloïde, les cellules T EL4, les cellules myélomonocytiques WEHI-3 et des cellules lymphoïdes pré-B, ou l es cellules hématopoïétiques prédifférenciées du sang de la moelle épinière humaine ou de la moelle de souris. Les anticorps anti SM1 peuvent servir à élaborer une préparation enrichie en cellules hématopoïétiques souches.
CA002289727A 1997-05-06 1998-05-01 Proteines sm1 presentes a la surface des cellules hematopoietiques souches Abandoned CA2289727A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4573097P 1997-05-06 1997-05-06
US60/045,730 1997-05-06
PCT/US1998/008829 WO1998050429A1 (fr) 1997-05-06 1998-05-01 Proteines sm1 presentes a la surface des cellules hematopoietiques souches

Publications (1)

Publication Number Publication Date
CA2289727A1 true CA2289727A1 (fr) 1998-11-12

Family

ID=21939559

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002289727A Abandoned CA2289727A1 (fr) 1997-05-06 1998-05-01 Proteines sm1 presentes a la surface des cellules hematopoietiques souches

Country Status (5)

Country Link
EP (1) EP0981546A4 (fr)
CN (1) CN1261897A (fr)
AU (1) AU7273998A (fr)
CA (1) CA2289727A1 (fr)
WO (1) WO1998050429A1 (fr)

Also Published As

Publication number Publication date
CN1261897A (zh) 2000-08-02
EP0981546A1 (fr) 2000-03-01
AU7273998A (en) 1998-11-27
WO1998050429A1 (fr) 1998-11-12
EP0981546A4 (fr) 2004-11-24

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued