CA2283071C - Serine proteinase inhibitory activity by hydrophobic tetracycline - Google Patents
Serine proteinase inhibitory activity by hydrophobic tetracycline Download PDFInfo
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- CA2283071C CA2283071C CA002283071A CA2283071A CA2283071C CA 2283071 C CA2283071 C CA 2283071C CA 002283071 A CA002283071 A CA 002283071A CA 2283071 A CA2283071 A CA 2283071A CA 2283071 C CA2283071 C CA 2283071C
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- tetracycline
- cmt
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- activity
- leukocyte elastase
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/816,551 | 1997-03-13 | ||
| US08/816,551 US5773430A (en) | 1997-03-13 | 1997-03-13 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
| PCT/US1998/003782 WO1998040079A1 (en) | 1997-03-13 | 1998-02-26 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2283071A1 CA2283071A1 (en) | 1998-09-17 |
| CA2283071C true CA2283071C (en) | 2009-01-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002283071A Expired - Fee Related CA2283071C (en) | 1997-03-13 | 1998-02-26 | Serine proteinase inhibitory activity by hydrophobic tetracycline |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5773430A (OSRAM) |
| EP (1) | EP0975349B1 (OSRAM) |
| JP (1) | JP4339411B2 (OSRAM) |
| KR (1) | KR100530683B1 (OSRAM) |
| AT (1) | ATE292972T1 (OSRAM) |
| AU (1) | AU733308B2 (OSRAM) |
| CA (1) | CA2283071C (OSRAM) |
| DE (1) | DE69829748T2 (OSRAM) |
| DK (1) | DK0975349T3 (OSRAM) |
| ES (1) | ES2241124T3 (OSRAM) |
| NZ (1) | NZ337578A (OSRAM) |
| PT (1) | PT975349E (OSRAM) |
| WO (1) | WO1998040079A1 (OSRAM) |
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| US6608112B1 (en) * | 1997-05-20 | 2003-08-19 | The Trustees Of Columbia University In The City Of New York | Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema |
| US5977091A (en) * | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| US6946453B2 (en) | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
| US6506740B1 (en) | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| US6887678B2 (en) * | 1998-12-02 | 2005-05-03 | Cindy L. Bristow | Method for the quantitative determination of proteinase inhibitors |
| WO2000066107A2 (en) * | 1999-04-30 | 2000-11-09 | Apt Pharmaceuticals, L.L.C. | Antimalarian agents for the treatment of asthma |
| GB0004531D0 (en) * | 2000-02-25 | 2000-04-19 | Richards Andrew J M | The treatment of respiratory diseases |
| US6627785B1 (en) * | 2000-02-29 | 2003-09-30 | Virginia Commwealth University | Wound dressings with protease-lowering activity |
| US6503892B2 (en) * | 2000-04-26 | 2003-01-07 | New England Medical Center Hospitals Inc. | Method of using matrix metalloproteinase inhibitors in filtering blebs following glaucoma filtering surgery and in the treatment of ischemic damage to the retina and optic nerve |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US7247704B2 (en) * | 2000-12-18 | 2007-07-24 | Arriva Pharmaceuticals, Inc. | Multifunctional protease inhibitors and their use in treatment of disease |
| AU2002256092C1 (en) * | 2001-04-05 | 2009-10-15 | Collagenex Pharmaceuticals, Inc. | Controlled delivery of tetracycline compounds and tetracycline derivatives |
| SG143977A1 (en) * | 2001-06-05 | 2008-07-29 | Auckland Uniservices Ltd | Methods and compositions for assessment of pulmonary function and disorders |
| JP2004537544A (ja) * | 2001-07-13 | 2004-12-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 標的治療活性を有するテトラサイクリン化合物 |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
| ES2551708T3 (es) | 2002-01-08 | 2015-11-23 | Paratek Pharmaceuticals, Inc. | Compuestos de 4-desdimetilamino tetraciclina |
| EP1482926A4 (en) | 2002-03-08 | 2006-04-12 | Paratek Pharm Innc | AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS |
| WO2003079984A2 (en) | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EA200900540A1 (ru) | 2002-07-12 | 2009-12-30 | Пэрэтек Фамэсьютикэлс, Инк. | Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта |
| US20040092491A1 (en) * | 2002-11-09 | 2004-05-13 | The Research Foundation Of State University Of New York | Method of treating sepsis-induced ARDS |
| CA2894736C (en) | 2003-04-07 | 2019-07-16 | Supernus Pharmaceuticals, Inc. | Once daily formulations of tetracyclines |
| EP1624866A2 (en) * | 2003-05-16 | 2006-02-15 | Arriva Pharmaceuticals, Inc. | Treatment of respiratory disease by inhalation of synthetic matrix metalloprotease inhibitors |
| JP4738333B2 (ja) | 2003-07-09 | 2011-08-03 | パラテック ファーマシューティカルズ インコーポレイテッド | ９−アミノメチルテトラサイクリン化合物のプロドラッグ |
| EP1648859B1 (en) | 2003-07-09 | 2013-02-27 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US7786099B2 (en) * | 2004-01-15 | 2010-08-31 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| WO2006047671A2 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP2269991A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060269946A1 (en) * | 2005-05-10 | 2006-11-30 | Young Robert P | Methods and compositions for assessment of pulmonary function and disorders |
| AU2006248201A1 (en) * | 2005-05-19 | 2006-11-23 | Synergenz Bioscience Limited | Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms |
| EP1888779A4 (en) * | 2005-05-20 | 2009-06-10 | Synergenz Bioscience Ltd | METHOD FOR THE ANALYSIS OF POLYMORPHISMS AND USES THEREOF |
| JP2009502809A (ja) * | 2005-07-21 | 2009-01-29 | パラテック ファーマシューティカルズ インコーポレイテッド | １０−置換テトラサイクリンおよびその使用方法 |
| US8795730B2 (en) * | 2006-01-31 | 2014-08-05 | David John Vachon | Compositions and methods for promoting the healing of tissue of multicellular organisms |
| PT2120963T (pt) * | 2006-12-21 | 2018-12-17 | Paratek Pharm Innc | Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele |
| EP2450347B1 (en) | 2006-12-21 | 2015-06-24 | Paratek Pharmaceuticals, Inc. | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections |
| JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| BRPI0813990A2 (pt) * | 2007-07-06 | 2011-09-13 | Paratek Pharmaceuticals, Inc. | métodos para sintetizar compostos de minociclina substituìda |
| TWI680117B (zh) | 2008-05-19 | 2019-12-21 | 派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| ES2558512T3 (es) | 2008-08-08 | 2016-02-04 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituida con C7-fluoro |
| BRPI0917711A2 (pt) | 2008-08-28 | 2017-06-20 | Astute Medical Inc | método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal |
| WO2010129057A2 (en) | 2009-05-08 | 2010-11-11 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| HUE037852T2 (hu) | 2009-08-28 | 2018-09-28 | Tetraphase Pharmaceuticals Inc | Tetraciklin-vegyületek |
| JP5820462B2 (ja) | 2010-03-31 | 2015-11-24 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | 多環式テトラサイクリン化合物 |
| SMT201900096T1 (it) | 2012-08-31 | 2019-02-28 | Tetraphase Pharmaceuticals Inc | Composti di tetracicline |
| MA46567A (fr) | 2016-10-19 | 2019-08-28 | Tetraphase Pharmaceuticals Inc | Formes cristallines de l'éravacycline |
| WO2020097450A1 (en) | 2018-11-09 | 2020-05-14 | Tetraphase Pharmaceuticals, Inc. | Polymorphic forms of a compound and uses thereof |
| WO2023133096A1 (en) * | 2022-01-04 | 2023-07-13 | The Research Foundation For The State University Of New York | Cmt-3 formulations and methods of using the same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935412A (en) * | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| USRE34656E (en) * | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) * | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US4666897A (en) * | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| US5223248A (en) * | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
| US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| DE69304292T2 (de) * | 1992-11-17 | 1997-01-02 | Univ New York | Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes |
| US5523297A (en) * | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| JP3929484B2 (ja) * | 1993-09-14 | 2007-06-13 | ジェネンテック・インコーポレーテッド | エコチンおよびその同族体を含む医薬的組成物 |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| GB9502152D0 (en) * | 1995-02-03 | 1995-03-29 | Zeneca Ltd | Proline derivatives |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
-
1997
- 1997-03-13 US US08/816,551 patent/US5773430A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 ES ES98908747T patent/ES2241124T3/es not_active Expired - Lifetime
- 1998-02-26 WO PCT/US1998/003782 patent/WO1998040079A1/en not_active Ceased
- 1998-02-26 JP JP53959398A patent/JP4339411B2/ja not_active Expired - Fee Related
- 1998-02-26 DK DK98908747T patent/DK0975349T3/da active
- 1998-02-26 DE DE69829748T patent/DE69829748T2/de not_active Expired - Lifetime
- 1998-02-26 EP EP98908747A patent/EP0975349B1/en not_active Expired - Lifetime
- 1998-02-26 AT AT98908747T patent/ATE292972T1/de active
- 1998-02-26 PT PT98908747T patent/PT975349E/pt unknown
- 1998-02-26 AU AU66698/98A patent/AU733308B2/en not_active Ceased
- 1998-02-26 NZ NZ337578A patent/NZ337578A/en not_active IP Right Cessation
- 1998-02-26 CA CA002283071A patent/CA2283071C/en not_active Expired - Fee Related
- 1998-02-26 KR KR10-1999-7008325A patent/KR100530683B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE292972T1 (de) | 2005-04-15 |
| KR20000076231A (ko) | 2000-12-26 |
| DE69829748D1 (de) | 2005-05-19 |
| ES2241124T3 (es) | 2005-10-16 |
| EP0975349B1 (en) | 2005-04-13 |
| NZ337578A (en) | 2001-08-31 |
| CA2283071A1 (en) | 1998-09-17 |
| KR100530683B1 (ko) | 2005-11-24 |
| DE69829748T2 (de) | 2006-03-09 |
| PT975349E (pt) | 2005-08-31 |
| US5773430A (en) | 1998-06-30 |
| WO1998040079A1 (en) | 1998-09-17 |
| AU6669898A (en) | 1998-09-29 |
| JP4339411B2 (ja) | 2009-10-07 |
| JP2001524948A (ja) | 2001-12-04 |
| DK0975349T3 (da) | 2005-08-01 |
| AU733308B2 (en) | 2001-05-10 |
| EP0975349A1 (en) | 2000-02-02 |
| EP0975349A4 (en) | 2002-10-30 |
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