CA2276018C - Chambre de pulverisation avec sechoir - Google Patents
Chambre de pulverisation avec sechoir Download PDFInfo
- Publication number
- CA2276018C CA2276018C CA002276018A CA2276018A CA2276018C CA 2276018 C CA2276018 C CA 2276018C CA 002276018 A CA002276018 A CA 002276018A CA 2276018 A CA2276018 A CA 2276018A CA 2276018 C CA2276018 C CA 2276018C
- Authority
- CA
- Canada
- Prior art keywords
- spray
- gas
- nebulizer
- droplets
- sheath gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007921 spray Substances 0.000 title claims abstract description 263
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000012528 membrane Substances 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 13
- 239000002904 solvent Substances 0.000 claims abstract description 9
- 239000002699 waste material Substances 0.000 claims abstract description 8
- 238000005054 agglomeration Methods 0.000 claims abstract description 6
- 230000002776 aggregation Effects 0.000 claims abstract description 6
- 230000002093 peripheral effect Effects 0.000 claims abstract 6
- 239000007789 gas Substances 0.000 claims description 184
- 239000006199 nebulizer Substances 0.000 claims description 117
- 239000007788 liquid Substances 0.000 claims description 48
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 26
- 229910052786 argon Inorganic materials 0.000 claims description 17
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 5
- 230000003134 recirculating effect Effects 0.000 claims description 5
- AUUAIQGEFIEHRO-UHFFFAOYSA-N 1,1,2,2-tetrafluoro-2-[1,1,1,2,3,3-hexafluoro-3-(1,2,2-trifluoroethenoxy)propan-2-yl]oxyethanesulfonic acid Chemical compound OS(=O)(=O)C(F)(F)C(F)(F)OC(F)(C(F)(F)F)C(F)(F)OC(F)=C(F)F AUUAIQGEFIEHRO-UHFFFAOYSA-N 0.000 claims description 2
- 238000011068 loading method Methods 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 58
- 239000000443 aerosol Substances 0.000 description 17
- 230000004044 response Effects 0.000 description 14
- 230000003446 memory effect Effects 0.000 description 11
- 239000012491 analyte Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 229920000557 Nafion® Polymers 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 6
- 239000010948 rhodium Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 5
- 229910052703 rhodium Inorganic materials 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000005755 formation reaction Methods 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000003595 mist Substances 0.000 description 4
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000283153 Cetacea Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003416 augmentation Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 229910000420 cerium oxide Inorganic materials 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000004807 desolvation Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000002663 nebulization Methods 0.000 description 2
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 description 2
- 229910052684 Cerium Inorganic materials 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- 241000238634 Libellulidae Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
- 238000005040 ion trap Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
- H01J49/049—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for applying heat to desorb the sample; Evaporation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
- H01J49/045—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol with means for using a nebulising gas, i.e. pneumatically assisted
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
L'invention concerne une chambre de pulvérisation permettant de produire un échantillon pour un analyseur susceptible de contenir une torche à plasma. Dans la chambre, un gaz de gainage chauffé est introduit dans la zone périphérique de pulvérisation entourant le jet de pulvérisation et au voisinage de la naissance du jet de pulvérisation, ce qui entraîne une réduction de la taille des gouttelettes qui sont recyclées, et a pour effet de réduire les phénomènes d'agglomération des gouttelettes et de favoriser un séchage rapide du produit de pulvérisation. De préférence, la totalité du solvant de pulvérisation s'évapore au niveau d'une chambre très courte, ce qui permet de réduire la quantité du produit de pulvérisation recyclée. L'ensemble du flux combiné des particules séchées issues de la pulvérisation, du gaz de nébulisation et du gaz de gainage est dirigé dans la torche. Dans un mode de réalisation, la partie centrale du flux combiné est dirigée vers la torche et la partie périphérique du flux combiné est évacuée de manière canalisé. Dans un autre mode de réalisation, le solvant aqueux de pulvérisation s'évapore totalement avant de quitter la chambre de pulvérisation, le flux combiné étant dirigé à travers un séchoir à membrane avant d'atteindre la torche, de façon à éliminer du flux la majeure partie de la vapeur d'eau et à réduire la vapeur d'eau venant charger la torche.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77859397A | 1997-01-03 | 1997-01-03 | |
| US08/778,593 | 1997-01-03 | ||
| US08/974,957 | 1997-11-20 | ||
| US08/974,957 US5969352A (en) | 1997-01-03 | 1997-11-20 | Spray chamber with dryer |
| PCT/CA1997/001007 WO1998029896A1 (fr) | 1997-01-03 | 1997-12-22 | Chambre de pulverisation avec sechoir |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2276018A1 CA2276018A1 (fr) | 1998-07-09 |
| CA2276018C true CA2276018C (fr) | 2004-11-23 |
Family
ID=27119475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002276018A Expired - Lifetime CA2276018C (fr) | 1997-01-03 | 1997-12-22 | Chambre de pulverisation avec sechoir |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1012871A1 (fr) |
| JP (1) | JP3831415B2 (fr) |
| AU (1) | AU5474598A (fr) |
| CA (1) | CA2276018C (fr) |
| WO (1) | WO1998029896A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7045015B2 (en) | 1998-09-30 | 2006-05-16 | Optomec Design Company | Apparatuses and method for maskless mesoscale material deposition |
| JP3902380B2 (ja) * | 2000-05-19 | 2007-04-04 | エスアイアイ・ナノテクノロジー株式会社 | Ｉｃｐ分析装置 |
| CN1270587C (zh) * | 2001-07-03 | 2006-08-16 | 瓦里安澳大利亚有限公司 | 等离子体喷灯 |
| US7479630B2 (en) * | 2004-03-25 | 2009-01-20 | Bandura Dmitry R | Method and apparatus for flow cytometry linked with elemental analysis |
| US7265362B2 (en) | 2004-02-06 | 2007-09-04 | Micromass Uk Limited | Mass spectrometer |
| DE202005001632U1 (de) * | 2004-02-06 | 2005-06-02 | Micromass Uk Ltd. | Massenspektrometer |
| US7294841B2 (en) | 2004-02-06 | 2007-11-13 | Micromass Uk Limited | Mass spectrometer |
| US7674671B2 (en) | 2004-12-13 | 2010-03-09 | Optomec Design Company | Aerodynamic jetting of aerosolized fluids for fabrication of passive structures |
| US7938341B2 (en) * | 2004-12-13 | 2011-05-10 | Optomec Design Company | Miniature aerosol jet and aerosol jet array |
| TWI482662B (zh) | 2007-08-30 | 2015-05-01 | Optomec Inc | 機械上一體式及緊密式耦合之列印頭以及噴霧源 |
| JP4982900B2 (ja) * | 2008-07-02 | 2012-07-25 | 独立行政法人産業技術総合研究所 | 脱溶媒機能付き誘導結合プラズマトーチ |
| KR200457166Y1 (ko) | 2008-12-16 | 2011-12-07 | 문무 주식회사 | 분말 건조 장치 |
| SG10201501031YA (en) | 2010-02-26 | 2015-04-29 | Perkinelmer Health Sci Inc | Fluid chromatography injectors and injector inserts |
| US9190253B2 (en) | 2010-02-26 | 2015-11-17 | Perkinelmer Health Sciences, Inc. | Systems and methods of suppressing unwanted ions |
| AU2011220352B2 (en) | 2010-02-26 | 2015-10-22 | Perkinelmer U.S. Llc | Plasma mass spectrometry with ion suppression |
| GB201216412D0 (en) * | 2012-09-14 | 2012-10-31 | Shimadzu Corp | Apparatus for providing gaseous sample ions/molecules and a corresponding method |
| JP2014211377A (ja) * | 2013-04-19 | 2014-11-13 | 株式会社堀場製作所 | 粒子分析装置 |
| KR102444204B1 (ko) | 2015-02-10 | 2022-09-19 | 옵토멕 인코포레이티드 | 에어로졸의 비행 중 경화에 의해 3차원 구조를 제조하는 방법 |
| JP6048552B1 (ja) * | 2015-08-21 | 2016-12-21 | 株式会社 イアス | オンライン移送した分析試料の分析システム |
| KR102042436B1 (ko) * | 2016-05-18 | 2019-11-08 | 퍼킨엘머 헬스 사이언스 캐나다 인코포레이티드 | 스프레이 챔버 및 이의 이용 방법 |
| CN110603441B (zh) * | 2017-05-12 | 2022-06-03 | 胜高股份有限公司 | 喷雾室、试样雾化导入装置、分析装置和试样中的成分分析方法 |
| EP3723909B1 (fr) | 2017-11-13 | 2023-10-25 | Optomec, Inc. | Dispositif d'arrêt de flux d'aérosol |
| CN116726519A (zh) * | 2023-06-14 | 2023-09-12 | 广东省麦思科学仪器创新研究院 | 雾化气细胞干燥装置和质谱流式细胞仪 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4990740A (en) * | 1989-03-06 | 1991-02-05 | The Dow Chemical Company | Intra-microspray ICP torch |
| US4958529A (en) * | 1989-11-22 | 1990-09-25 | Vestec Corporation | Interface for coupling liquid chromatography to solid or gas phase detectors |
| US5122670A (en) * | 1991-05-17 | 1992-06-16 | Finnigan Corporation | Multilayer flow electrospray ion source using improved sheath liquid |
| EP0560537A1 (fr) * | 1992-03-10 | 1993-09-15 | Mds Health Group Limited | Dispositif et méthode pour l'introduction d'échantillons liquides |
| CA2062629C (fr) * | 1992-03-10 | 1999-06-15 | John Barry French | Appareil et methode d'introduction d'echantillon liquide |
-
1997
- 1997-12-22 EP EP97951050A patent/EP1012871A1/fr not_active Withdrawn
- 1997-12-22 WO PCT/CA1997/001007 patent/WO1998029896A1/fr active Application Filing
- 1997-12-22 JP JP52951298A patent/JP3831415B2/ja not_active Expired - Lifetime
- 1997-12-22 AU AU54745/98A patent/AU5474598A/en not_active Abandoned
- 1997-12-22 CA CA002276018A patent/CA2276018C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5474598A (en) | 1998-07-31 |
| JP2001507449A (ja) | 2001-06-05 |
| JP3831415B2 (ja) | 2006-10-11 |
| EP1012871A1 (fr) | 2000-06-28 |
| CA2276018A1 (fr) | 1998-07-09 |
| WO1998029896A1 (fr) | 1998-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20171222 |