CA2275504C - Pharmacogenetic methods for use in the treatment of nervous system diseases - Google Patents
Pharmacogenetic methods for use in the treatment of nervous system diseases Download PDFInfo
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12Q2600/00—Oligonucleotides characterized by their use
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| US08/766,975 | 1996-12-16 | ||
| US08/766,975 US6022683A (en) | 1996-12-16 | 1996-12-16 | Methods for assessing the prognosis of a patient with a neurodegenerative disease |
| PCT/IB1997/001648 WO1998027227A2 (en) | 1996-12-16 | 1997-12-16 | Pharmacogenetic methods for use in the treatment of nervous system diseases |
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| CA2275504A1 CA2275504A1 (en) | 1998-06-25 |
| CA2275504C true CA2275504C (en) | 2009-09-22 |
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| CA2275404A Expired - Fee Related CA2275404C (en) | 1996-12-16 | 1997-12-16 | Method for determining the prognosis of a patient with a neurological disease |
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| CA2275404A Expired - Fee Related CA2275404C (en) | 1996-12-16 | 1997-12-16 | Method for determining the prognosis of a patient with a neurological disease |
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| CA (2) | CA2275504C (https=) |
| DE (2) | DE69729473T2 (https=) |
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| US6022683A (en) * | 1996-12-16 | 2000-02-08 | Nova Molecular Inc. | Methods for assessing the prognosis of a patient with a neurodegenerative disease |
| US6441149B1 (en) | 1998-06-15 | 2002-08-27 | Mitokor | Diagnostic method based on quantification of extramitochondrial DNA |
| US6489095B2 (en) | 1998-06-15 | 2002-12-03 | Mitokor | Diagnostic method based on quantification of extramitochondrial DNA |
| US6218117B1 (en) | 1998-06-15 | 2001-04-17 | Mitokor | Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios |
| CA2330829C (en) | 1998-06-16 | 2011-08-02 | Variagenics, Inc. | Methods for treating a neurological disease by determining bche genotype |
| JP2002526124A (ja) | 1998-10-01 | 2002-08-20 | ノヴァ モレキュラー インク． | 変異型ｇｐｉｉｉａ対立遺伝子および／または変異型ｇｐｉｉｂ対立遺伝子の存在を決定することにより、神経系疾患のリスクを有する対象を治療又は同定する方法 |
| AU773329B2 (en) * | 1999-05-14 | 2004-05-20 | Proteomedica Ab | Materials and methods relating to disease diagnosis |
| JP2003521024A (ja) * | 1999-06-25 | 2003-07-08 | ジェネサンス・ファーマシューティカルズ・インコーポレーテッド | ハプロタイプデータの入手および使用のための方法 |
| US7058517B1 (en) | 1999-06-25 | 2006-06-06 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
| US6692916B2 (en) * | 1999-06-28 | 2004-02-17 | Source Precision Medicine, Inc. | Systems and methods for characterizing a biological condition or agent using precision gene expression profiles |
| US6960439B2 (en) * | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
| US6573049B1 (en) | 1999-07-26 | 2003-06-03 | Nuvelo, Inc. | Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease |
| US6896881B1 (en) | 1999-09-24 | 2005-05-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| AU2001240820A1 (en) * | 2000-03-15 | 2001-09-24 | Oxford Glycosciences (Uk) Ltd. | Proteins, genes and their use for diagnosis and treatment of vascular dementia |
| US20070179197A1 (en) * | 2000-05-01 | 2007-08-02 | Accera, Inc. | Compositions and methods for improving or preserving brain function |
| WO2007115282A2 (en) * | 2006-04-03 | 2007-10-11 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
| AU2001257451A1 (en) | 2000-05-01 | 2001-11-12 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism |
| US6835750B1 (en) | 2000-05-01 | 2004-12-28 | Accera, Inc. | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II |
| US20080009467A1 (en) * | 2000-05-01 | 2008-01-10 | Accera, Inc. | Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism |
| US6931326B1 (en) | 2000-06-26 | 2005-08-16 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
| US20030105082A1 (en) * | 2001-12-03 | 2003-06-05 | Murphy Greer Marechal | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| US20040106124A1 (en) * | 2001-02-12 | 2004-06-03 | Murphy Greer M. | Methods for improving the treatment of major depression by genotyping for the gene for apolipoproteine e4 and for improving the terapeutic response of humans having major depression and carrying the gene for apolipoprotein e4 |
| US6399310B1 (en) | 2001-02-12 | 2002-06-04 | Akzo Nobel N.V. | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| GB0106051D0 (en) * | 2001-03-12 | 2001-05-02 | Isis Innovation | Diagnostic screens for alzheimer's disease |
| US20030104453A1 (en) * | 2001-11-06 | 2003-06-05 | David Pickar | System for pharmacogenetics of adverse drug events |
| CN1612936A (zh) * | 2001-11-09 | 2005-05-04 | 苏尔斯精细医药公司 | 利用基因表达分布图识别、监控和治疗疾病以及鉴定生物学状态 |
| US20030224446A1 (en) * | 2001-12-20 | 2003-12-04 | Harry G. Jean | Method of predicting cytokine response to tissue injury |
| US20040267458A1 (en) * | 2001-12-21 | 2004-12-30 | Judson Richard S. | Methods for obtaining and using haplotype data |
| WO2003069431A2 (en) * | 2002-02-14 | 2003-08-21 | Medavante, Inc. | System and method for facilitating candidate and subject participation in clinical trial studies |
| US7432355B2 (en) * | 2002-08-09 | 2008-10-07 | The J. David Gladstone Institutes | Apolipoprotein E stable folding intermediate and methods of use thereof |
| US8688385B2 (en) | 2003-02-20 | 2014-04-01 | Mayo Foundation For Medical Education And Research | Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype |
| CA2525517C (en) * | 2003-06-19 | 2016-05-31 | Applied Research Systems Ars Holding N.V. | Use of prion conversion modulating agents |
| US20050038692A1 (en) * | 2003-08-14 | 2005-02-17 | Kane John Michael | System and method for facilitating centralized candidate selection and monitoring subject participation in clinical trial studies |
| WO2005073892A2 (en) * | 2004-01-16 | 2005-08-11 | Disease Management Services, Plc | Disease management system |
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| US20060252775A1 (en) * | 2005-05-03 | 2006-11-09 | Henderson Samuel T | Methods for reducing levels of disease associated proteins |
| WO2007001883A2 (en) * | 2005-06-20 | 2007-01-04 | Accera, Inc. | Method to reduce oxidative damage and improve mitochondrial efficiency |
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| JP3265577B2 (ja) * | 1992-10-13 | 2002-03-11 | デューク・ユニバーシティ | アポリポ蛋白ｅの４型イソ型の測定法 |
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| GB9414624D0 (en) * | 1994-07-20 | 1994-09-07 | Smithkline Beecham Plc | Novel method |
| US6022683A (en) * | 1996-12-16 | 2000-02-08 | Nova Molecular Inc. | Methods for assessing the prognosis of a patient with a neurodegenerative disease |
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| JP2001524809A (ja) | 2001-12-04 |
| WO1998027227A2 (en) | 1998-06-25 |
| US6022683A (en) | 2000-02-08 |
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| EP0946753B1 (en) | 2004-06-09 |
| AU5675798A (en) | 1998-07-15 |
| ATE269978T1 (de) | 2004-07-15 |
| EP0948647A1 (en) | 1999-10-13 |
| JP5202429B2 (ja) | 2013-06-05 |
| CA2275404A1 (en) | 1998-06-25 |
| AU745073B2 (en) | 2002-03-14 |
| EP0948647B1 (en) | 2004-06-23 |
| US7001736B1 (en) | 2006-02-21 |
| CA2275404C (en) | 2011-02-08 |
| WO1998027227A3 (en) | 1998-08-27 |
| DE69729473D1 (de) | 2004-07-15 |
| DE69729654D1 (de) | 2004-07-29 |
| AU5571798A (en) | 1998-07-15 |
| EP0946753A2 (en) | 1999-10-06 |
| CA2275504A1 (en) | 1998-06-25 |
| JP2009213482A (ja) | 2009-09-24 |
| DE69729473T2 (de) | 2005-06-09 |
| DE69729654T2 (de) | 2005-07-21 |
| JP2012152229A (ja) | 2012-08-16 |
| WO1998027226A2 (en) | 1998-06-25 |
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