CA2275404C - Method for determining the prognosis of a patient with a neurological disease - Google Patents

Method for determining the prognosis of a patient with a neurological disease Download PDF

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Publication number
CA2275404C
CA2275404C CA2275404A CA2275404A CA2275404C CA 2275404 C CA2275404 C CA 2275404C CA 2275404 A CA2275404 A CA 2275404A CA 2275404 A CA2275404 A CA 2275404A CA 2275404 C CA2275404 C CA 2275404C
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Canada
Prior art keywords
patient
disease
genotype
stroke
prognosis
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2275404A
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English (en)
French (fr)
Other versions
CA2275404A1 (en
Inventor
Pierre Sevigny
Heiko Wiebusch
Keith Schappert
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Novartis International Pharmaceutical Ltd
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Novartis International Pharmaceutical Ltd
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Publication of CA2275404A1 publication Critical patent/CA2275404A1/en
Application granted granted Critical
Publication of CA2275404C publication Critical patent/CA2275404C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
CA2275404A 1996-12-16 1997-12-16 Method for determining the prognosis of a patient with a neurological disease Expired - Fee Related CA2275404C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/766,975 1996-12-16
US08/766,975 US6022683A (en) 1996-12-16 1996-12-16 Methods for assessing the prognosis of a patient with a neurodegenerative disease
PCT/IB1997/001641 WO1998027226A2 (en) 1996-12-16 1997-12-16 Method for determining the prognosis of a patient with a neurological disease

Publications (2)

Publication Number Publication Date
CA2275404A1 CA2275404A1 (en) 1998-06-25
CA2275404C true CA2275404C (en) 2011-02-08

Family

ID=25078098

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2275404A Expired - Fee Related CA2275404C (en) 1996-12-16 1997-12-16 Method for determining the prognosis of a patient with a neurological disease
CA002275504A Expired - Fee Related CA2275504C (en) 1996-12-16 1997-12-16 Pharmacogenetic methods for use in the treatment of nervous system diseases

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002275504A Expired - Fee Related CA2275504C (en) 1996-12-16 1997-12-16 Pharmacogenetic methods for use in the treatment of nervous system diseases

Country Status (8)

Country Link
US (2) US6022683A (enExample)
EP (2) EP0948647B1 (enExample)
JP (4) JP2001524809A (enExample)
AT (1) ATE269978T1 (enExample)
AU (2) AU5571798A (enExample)
CA (2) CA2275404C (enExample)
DE (2) DE69729473T2 (enExample)
WO (2) WO1998027226A2 (enExample)

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US6441149B1 (en) 1998-06-15 2002-08-27 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
US6218117B1 (en) 1998-06-15 2001-04-17 Mitokor Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios
US6489095B2 (en) 1998-06-15 2002-12-03 Mitokor Diagnostic method based on quantification of extramitochondrial DNA
EP1088104B1 (en) * 1998-06-16 2006-02-08 Nova Molecular, Inc. Methods for treating a neurological disease by determining bche genotype
WO2000020634A1 (en) 1998-10-01 2000-04-13 Nova Molecular, Inc. Methods for treating or identifying a subject at risk for a neurological disease by determining the presence of a variant gpiiia and/or variant gpiib allele
WO2000070340A2 (en) * 1999-05-14 2000-11-23 Karolinska Innovations Ab Materials and methods relating to disease diagnosis
DE1233365T1 (de) * 1999-06-25 2003-03-20 Genaissance Pharmaceuticals Inc., New Haven Verfahren zur herstellung und verwendung von Haplotype Daten
US7058517B1 (en) 1999-06-25 2006-06-06 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US6573049B1 (en) 1999-07-26 2003-06-03 Nuvelo, Inc. Genotyping of the paraoxonase 1 gene for prognosing, diagnosing, and treating a disease
US6896881B1 (en) * 1999-09-24 2005-05-24 Mayo Foundation For Medical Education And Research Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
AU2001240820A1 (en) * 2000-03-15 2001-09-24 Oxford Glycosciences (Uk) Ltd. Proteins, genes and their use for diagnosis and treatment of vascular dementia
US20080009467A1 (en) * 2000-05-01 2008-01-10 Accera, Inc. Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism
US20070179197A1 (en) * 2000-05-01 2007-08-02 Accera, Inc. Compositions and methods for improving or preserving brain function
US8124589B2 (en) 2000-05-01 2012-02-28 Accera, Inc. Use of ketogenic compounds for treatment of age-associated memory impairment
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
WO2001082928A1 (en) * 2000-05-01 2001-11-08 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism
US6931326B1 (en) 2000-06-26 2005-08-16 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US6399310B1 (en) 2001-02-12 2002-06-04 Akzo Nobel N.V. Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
WO2002064735A2 (en) * 2001-02-12 2002-08-22 Akzo Nobel N.V. Methods for improving the treatment of major depression by genotyping for the gene for apolipoproteine e4
US20030105082A1 (en) * 2001-12-03 2003-06-05 Murphy Greer Marechal Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
GB0106051D0 (en) * 2001-03-12 2001-05-02 Isis Innovation Diagnostic screens for alzheimer's disease
US20030104453A1 (en) * 2001-11-06 2003-06-05 David Pickar System for pharmacogenetics of adverse drug events
EP1451340B1 (en) 2001-11-09 2014-01-08 Life Technologies Corporation Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US20030224446A1 (en) * 2001-12-20 2003-12-04 Harry G. Jean Method of predicting cytokine response to tissue injury
US20040267458A1 (en) * 2001-12-21 2004-12-30 Judson Richard S. Methods for obtaining and using haplotype data
WO2003069431A2 (en) * 2002-02-14 2003-08-21 Medavante, Inc. System and method for facilitating candidate and subject participation in clinical trial studies
US7432355B2 (en) * 2002-08-09 2008-10-07 The J. David Gladstone Institutes Apolipoprotein E stable folding intermediate and methods of use thereof
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
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US20050038692A1 (en) * 2003-08-14 2005-02-17 Kane John Michael System and method for facilitating centralized candidate selection and monitoring subject participation in clinical trial studies
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KR20070033032A (ko) 2004-07-16 2007-03-23 프로테오시스 악티엔게젤샤프트 세포보호제로서 parp 및 sir 조절 활성을 갖는무스카린 길항제
US20060252775A1 (en) * 2005-05-03 2006-11-09 Henderson Samuel T Methods for reducing levels of disease associated proteins
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CA2630604C (en) * 2005-11-29 2016-01-19 Children's Hospital Medical Center Optimization and individualization of medication selection and dosing
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US20090198504A1 (en) * 2008-02-05 2009-08-06 Medavante, Inc. Rater resource allocation systems and methods
US9125881B2 (en) * 2008-07-03 2015-09-08 Accera, Inc. Monoglyceride of acetoacetate and derivatives for the treatment of neurological disorders
US8105809B2 (en) * 2008-07-03 2012-01-31 Accera, Inc. Enzymatic synthesis of acetoacetate esters and derivatives
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Also Published As

Publication number Publication date
WO1998027227A3 (en) 1998-08-27
CA2275504C (en) 2009-09-22
AU5571798A (en) 1998-07-15
EP0948647B1 (en) 2004-06-23
WO1998027226A2 (en) 1998-06-25
AU745073B2 (en) 2002-03-14
JP2013059347A (ja) 2013-04-04
EP0948647A1 (en) 1999-10-13
DE69729654D1 (de) 2004-07-29
WO1998027226A3 (en) 1998-08-20
ATE269978T1 (de) 2004-07-15
AU5675798A (en) 1998-07-15
DE69729654T2 (de) 2005-07-21
CA2275404A1 (en) 1998-06-25
WO1998027227A2 (en) 1998-06-25
JP2009213482A (ja) 2009-09-24
JP2012152229A (ja) 2012-08-16
US6022683A (en) 2000-02-08
CA2275504A1 (en) 1998-06-25
US7001736B1 (en) 2006-02-21
DE69729473T2 (de) 2005-06-09
EP0946753A2 (en) 1999-10-06
JP5202429B2 (ja) 2013-06-05
EP0946753B1 (en) 2004-06-09
DE69729473D1 (de) 2004-07-15
JP2001524809A (ja) 2001-12-04

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Effective date: 20141216